Day: August 14, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.302964-20-1,tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate,as a common compound, the synthetic route is as follows.

Into a clean and dry 3L 4-neck round bottom flask connected to a mechanical stirrer,condenser and thermometer socket is charged with 2-tert-butoxycarbonylamino-thiazole-5-carboxylic acid chloride (4) crude (27.5 g) and dichloromethane (750 mL) under stirring. Cooled the reaction mass to 0-5 C and add 2-chloro-6-methylaniline (22.2 g) to the reaction mass at 0-5 C within 30-45 min period. Added DiPEA to the reaction mass at 0-5 C in 30-45 min period, raised the reaction mass temperature to 25-30 C and stirred the reaction mass at 25-30 C for 24 h. After TLC compliance distilled-off the solvent completely under plant vacuum at the temperature not crossing 50 C and Charge 2 N HCl (250 mL) to the reaction mass, Stirred for 15-30 min. Transferred the reaction mass into a Buchner funnel and flask kept under plant vacuum. The wet cake is washed with 500mL of water and dried the above-wet material in the dryer at temperature 60-65 C for 10-12 h. Purification: Into a clean and dry 3.0 L 4-neck round bottom flask connected to a mechanical stirrer, condenser, thermometer socket is charging with 2-tert-butoxy-carbonyl-amino-N-(2-chloro-6-methylphenyl)-5-thiazolecarboxamide crude, methanol and isopropyl ether under stirring at 25- 30 C. Raised the reaction mass temperature to 60-65 C and stirred the reaction mass at 60-65 C for 45-60 min. Cooled the reaction mass temperature to 25-30 C and transferred the reaction mass into a Buchner funnel and flask kept under plant vacuum. Washed the wet cake with 20.0 mL of methanol and dried the wet material in dryer at 60-65 C for 4-6 h to furnish 16.0 g of the title compound with purity above 95 %. Cream colour solid; Elemental analysis C16H18N3O3SClcalcd (found) %: C 52.24 (52.12), H 4.93 (5.05), N 11.42 (11.31),O 13.05 (13.25), S 8.72 (8.83). IR (KBr, numax, cm-1): 3423.42-3276.87, 3162.67, 2928.46, 1724.90, 1632.68-1566, 1522.80,775.21; 1H NMR (400 MHz, DMSO-d6): delta1.504 (s, 9H, -3CH3),2.225 (s, 3H, -CH3), 7.262-7.301 (t, 2H, ArH), 7.389-7.412(m, 1H, ArH), 8.204 (s, 1H, ArH), 10.017 (s, 1H, -NH), 11.847(s, 1H, -NH); 13C NMR (100 MHz, DMSO-d6): delta163.220, 159.74,152.91, 141.27, 139.02, 133.31, 132.57, 129.34, 128.64, 127.28,126.62, 82.33, 28.06, 18.45; ESI-MS (m/z): 368.21 (M+1),370.18 (M+3)

302964-20-1 tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate 45117870, athiazole compound, is more and more widely used in various.

Reference£º
Article; Buchappa; Sagar Vijay Kumar; Durga Prasad; Aparna; Asian Journal of Chemistry; vol. 30; 7; (2018); p. 1621 – 1628;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-22-8, 5-Bromothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 25; 5-Bromo-2-(2,5-dimethylpyrrol- 1 -yl)thiazoleNeutralize 2-amino-5-bromothiazole hydrobromide (2.90 g, 16.2 mmol of free amine) by treating with Na2CO3 and then add it to a mixture of hexane-2,5- dione (2.04 g, 17.8 mmol) and acetic acid (1.1 mL) in benzene. Heat the mixture EPO for 18 h in a flask equipped with a Dean-Stark trap. Filter and concentrate in vacuo to give a dark oil. Chromatograph the oil over silica eluting with 20 – 80percent EtOAc/hexanes to yield 2.95 g (71percent) of a yellow oil. MS (ES): 259 (M+l), 261 (M+H+2).

The synthetic route of 3034-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2933-29-1, 2-Amino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

i. 4-Hydroxy-2-methyl-N-(4,5,6,7-tetrahydro-2-benzothiazolyl)- 2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide, m. p. 255-257 C (decomp.; from ethylene chloride), from 2-methyl-4-(1-pyrrolidyl)-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxylic acidchloride-1,1-dioxide and 2-amino-4,5,6,7-tetrahydrobenzothiazole.

As the paragraph descriping shows that 2933-29-1 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim GmbH; US3992535; (1976); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

121-66-4, 5-Nitrothiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Chloroacetyl chloride (2 mmol) was added drop wise to a well stirred suspension of corresponding amine (1 mmol) and TEA (3 mmol) in DMF (15 mL) at 0 C. The reaction mixture was then stirred at rt for about 3 h (monitored by TLC & LCMS for completion), and the solvent evaporated under reduced pressure. The residue was further diluted with water (20 mL) and ethyl acetate (30 mL), and the layers separated. The aqueous layer was reextracted with ethyl acetate (2 x 30 mL) and the combined organic layer was washed with brine (20 mL), dried over anhydrous sodium sulphate and evaporated under reduced pressure. The residue was purified by silica column chromatography using hexane:ethyl acetate as eluent to give corresponding 2-chloro-N-(aryl/heteroaryl)acetamides (28a-c).

The synthetic route of 121-66-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pedgaonkar, Ganesh S.; Sridevi, Jonnalagadda Padma; Jeankumar, Variam Ullas; Saxena, Shalini; Devi, Parthiban Brindha; Renuka, Janupally; Yogeeswari, Perumal; Sriram, Dharmarajan; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 613 – 627;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

90533-23-6, 4-(3-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of 4-(3-bromopropoxy)benzaldehyde (200.00 mg, 0.82 mmol)and 4-phenylthiazol-2-amine (144.50 mg, 0.82 mmol) in DMF (15 mL),potassium carbonate (170.00 mg, 1.23 mmol) was added. The reaction mixturewas refluxed for 12 h. The reaction mixture was quenched with water,and extracted with toluene (20 mL*3). The combined organic layer waswashed with brine, dried with anhydrous sodium sulphate, concentratedunder vacuum, then purified by flash chromatography (petroleum ether:ethyl acetate = 3:1) to afford a colorless solid. Yield 32.3%. The procedure described for the synthesis of compound 3a can also beapplied to the synthesis of compounds 3b-o.

The synthetic route of 90533-23-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Jingbao; Deng, Xinxian; Jin, Yan; Xu, Buzhe; Liu, Wenlu; Jiang, Faqin; Fu, Lei; Pharmazie; vol. 70; 7; (2015); p. 446 – 451;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.

To a solution of 4-bromothiazole-2-carboxylic acid (40.0 mg, 0.19 mmol) in DMF (3.0mL), HBTU (86 mg, 0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temp for 2 h, concentrated under reduced pressure and dried by vacuum. DCM (3.0 mL) was added to the residue and the resulting solution was cooled to 0 C and 2-aminopyridine (20.0 mg, 0.20 mmol),TEA (0.2 mL, 1.43 mmol) was added. The mixture was stirred at room temperature 3 h. The subsequent mixture was concentrated under reduced pressure andextracted with H2O/ethyl acetate. The combined organic layer wasdried by Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) toafford the title compound 6be (25.0 mg, 46 %) as white solid; 1H-NMR(400 MHz, CDCl3) delta 9.56(s, 1H), 8.36 (dq, J = 4.8, 0.8 Hz,1H), 8.27 (d, J = 8.4 Hz , 1H), 7.76(t, J = 7.6 Hz, 1H), 7.54 (s, 1H),7.11 (ddd, J = 7.2, 4.8, 0.8 Hz, 1H).13C-NMR (100 MHz, CDCl3) delta 163.3, 156.4, 150.3, 148.4, 138.4, 126.1,124.1, 120.6, 114.2. LC/MS (ESI-) 283.9 (M+H)+.

As the paragraph descriping shows that 88982-82-5 is playing an increasingly important role.

Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

7305-71-7, 2-Amino-5-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of -corresponding hetero amines a?e (0.04?mol) and triethyl amine (0.04?mol) in chloroform (200?ml) was added drop wise chloroacetyl chloride (0.04?mol) at 0?5?¡ãC. After addition, the resulting mixture was stirred overnight at room temperature. Reaction completion was monitored through thin layer chromatography using hexane:ethyl acetate (8:2) as mobile phase. The reaction mixture was concentrated to get solid and as such taken in the methanol solution. The precipitates thus separated out were allowed to stand 2?h. The resultant solid 1a?e was filtered, washed, dried and as such taken for the next step.

As the paragraph descriping shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Article; Patel, Navin B.; Purohit, Amit C.; Rajani, Dhanji P.; Moo-Puc, Rosa; Rivera, Gildardo; European Journal of Medicinal Chemistry; vol. 62; (2013); p. 677 – 687;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78485-37-7,Ethyl 2-chloro-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

To ethyl 2-chlorobenzo[d]thiazole-6-carboxylate (1d-1) (305 mg, 1.263 mmol) and (1R,3R,5S)-N-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)-8-azabicyclo[3.2.1]octan-3-amine hydrochloride (1c-1) (430 mg, 0.842 mmol, ?84% by weight) in DMA (5 ml) was added cesium carbonate (686 mg, 2.105 mmol). The resulting mixture was heated up to 60 C. for 16 h, cooled down to room temperature. The mixture was diluted with ethyl acetate, washed with water (4*), brine, dried, filtered, and concentrated. The residue was chromatographed by CombiFlash eluting with hexane to 70% ethyl acetate/hexane to give ethyl 2-((1R,3R,5S)-3-(((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methyl)amino)-8-azabicyclo[3.2.1]octan-8-yl)benzo[d]thiazole-6-carboxylate (Example 1) (198 mg). LC/MS observed [M+H], 597.15.

As the paragraph descriping shows that 78485-37-7 is playing an increasingly important role.

Reference£º
Patent; Enanta Pharmaceuticals, Inc.; Ma, Jun; Wang, Guoqiang; Wang, Bin; Xing, Xuechao; Shen, Ruichao; He, Jing; Or, Yat Sun; (530 pag.)US2018/99957; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

173979-01-6, 4-(Tributylstannyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(R)-7-(4-bromo-lH-imidazol-l-yl)-5-cyclopentyl-4-ethyl-4,5-dihydro- [l,2,4]triazolo[4,3-f]pteridine (Example 93), 4-(tributylstannyl)thiazole (1 eq, seeExample 693) and Pd(PPli3)4 (0.1 eq) are dissolved in DMF in a screw cap vial and a stream of nitrogen is bubbled through the mixture for 2 minutes. The vial is sealed and the resulting solution is stirred at 100 C for 19 h. The reaction mixture is diluted with brine, extracted with EtOAc, dried with Na2S04 then purified by flash chromatography with a silica gel column by eluting with a mixture of Hexane:EtOAc and then further purified by preparative HPLC to give the title compound.

The synthetic route of 173979-01-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; NEITZ, R., Jeffrey; TROUNG, Anh, P.; GALEMMO, Robert, A.; YE, Xiaocong, Michael; SEALY, Jennifer; ADLER, Marc; BOWERS, Simeon; BEROZA, Paul; ANDERSON, John, P.; AUBELE, Danielle, L.; ARTIS, Dean, Richard; HOM, Roy, K.; ZHU, Yong-liang; WO2012/48129; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

tert-Butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate (2.0 g, 8.68 mmol) was taken up in 25 mL of CH2Cl2 along with Et3N (1.82 mL, 13.05 mmol) and cooled to 0 C. Methanesulfonyl chloride (0.85 mL, 10.88 mmol) was added and the resulting reaction mixture was stirred at 0 C for 60 min. Morpholine (3.0 mL, 35 mmol) was then added and the reaction mixture was stirred at room temp for 18 h. The reaction mixture was concentrated under reduced pressure. The resulting residue was taken up in EtOAc and washed with dilute aqueous NaHCO3, brine, dried with Na2SO4, and concentrated under reduced pressure. This material was purified by filtering through a short column of silica gel. The filtrate was concentrated to afford tert-butyl 4-(morpholinomethyl)thiazol-2-ylcarbamate (1.88 g, 69 % yield).

494769-44-7 tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate 22280475, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GlaxoSmithKline LLC; CASAUBON, Rebecca, L.; NARAYAN, Radha; OALMANN, Christopher; VU, Chi, B.; (583 pag.)EP2768509; (2017); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica