With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.88982-82-5,4-Bromo-1,3-thiazole-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 4-bromothiazole-2-carboxylic acid (40.0 mg, 0.19 mmol) in DMF (3.0mL), HBTU (86 mg, 0.23 mmol) was added dropwise, and then DMF (2 drops) was added. The mixture was stirred at room temp for 2 h, concentrated under reduced pressure and dried by vacuum. DCM (3.0 mL) was added to the residue and the resulting solution was cooled to 0 C and 2-aminopyridine (20.0 mg, 0.20 mmol),TEA (0.2 mL, 1.43 mmol) was added. The mixture was stirred at room temperature 3 h. The subsequent mixture was concentrated under reduced pressure andextracted with H2O/ethyl acetate. The combined organic layer wasdried by Na2SO4, concentrated under reduced pressure and purified by column chromatography on silica gel (hexane/ethyl acetate = 5:1) toafford the title compound 6be (25.0 mg, 46 %) as white solid; 1H-NMR(400 MHz, CDCl3) delta 9.56(s, 1H), 8.36 (dq, J = 4.8, 0.8 Hz,1H), 8.27 (d, J = 8.4 Hz , 1H), 7.76(t, J = 7.6 Hz, 1H), 7.54 (s, 1H),7.11 (ddd, J = 7.2, 4.8, 0.8 Hz, 1H).13C-NMR (100 MHz, CDCl3) delta 163.3, 156.4, 150.3, 148.4, 138.4, 126.1,124.1, 120.6, 114.2. LC/MS (ESI-) 283.9 (M+H)+.
As the paragraph descriping shows that 88982-82-5 is playing an increasingly important role.
Reference£º
Article; Vu, Hoang Nam; Kim, Ji Young; Hassan, Ahmed H.E.; Choi, Kihang; Park, Jong-Hyun; Park, Ki Duk; Lee, Jae Kyun; Pae, Ae Nim; Choo, Hyunah; Min, Sun-Joon; Cho, Yong Seo; Bioorganic and Medicinal Chemistry Letters; vol. 26; 1; (2016); p. 140 – 144;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica