With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20949-84-2,4-Formyl-2-methylthiazole,as a common compound, the synthetic route is as follows.
Sodium bicarbonate (6.6 g, 78.7 mmol) was added to 2-methylthiazole-4-carbaldehyde (5.0 g, 39.4 mmol), S-methylisothiourea sulfate (8.3 g, 59.1 mmol) and ethyl acetoacetate (5.12 g, 39.4 mmol) of N, N-dimethylformyl (60 mL). After the reaction mixture was stirred at 70 C for 3 hours, it was cooled to room temperature. Water (500 mL) was added, and a yellow solid precipitated, filtered, and the filter cake was washed with water (200 mL) and dried under vacuum to obtain compound 82-f (3.5 g, yield: 29%).
As the paragraph descriping shows that 20949-84-2 is playing an increasingly important role.
Reference£º
Patent; Shanghai Zaiji Pharmaceutical Technology Co., Ltd.; Wang Yuguang; Zhang Nong; Wu Tianzhi; Wu Xinliang; (132 pag.)CN110872297; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica