With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.
Ortho triethyl formate (10 ml) and SP-112 [H+] (1.0 g) were added in ethanol (62 ml) solution of 145 (5.18 g, 45.78 mmol), and the resulting solution was refluxed for 5 hours. SP-112 [H+] of the reaction solution was separated by filtration, and the filtrate was distilled away under reducing pressure to filtrate the solvent. The residue was purified by silica gel column chromatography (elution solvent: ethyl acetate/n-hexane = 4/1) to obtain 146 (8.57 g, 100percent) as a colorless oily substance. APCI-MS m/z 188[M+H]+
The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Tohoku University; EP2103611; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica