32955-21-8, Ethyl 2-aminothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a stirred solution of ethyl 2-aminothiazole-5-carboxylate (10.0 g, 46.45 mmol, Combi block) in 48% HBr (75 mL), sodium nitrite (4.80 g, 69.68 mmol) in water (50mL) was added dropwise at 0 C and the reaction mixture was stirred at 0 C for 15 mm. Copper(l) bromide (6.66 g, 46.45 mmol) in 48% HBr (75 mL) was added dropwise at 0 C and the reaction mixture was stirred at rt for 4h. The reaction mixture was diluted with DCM (200 mL) and washed with water (50 mL), brine (50mL), dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by flash chromatography (100% CHCl3) to afford the title compound. Yield: 50.18% (5.5 g, yellow liquid). 1H NMR (400 MHz, DMSO-d6): delta 8.16 (s, 1H), 4.38 (q, J= 7.16 Hz, 2H), 1.40 (t, J= 7.12 Hz, 3H). LCMS: (Method A) 235.9 (M+H), Rt. 3.85 min, 98.6% (Max).
As the paragraph descriping shows that 32955-21-8 is playing an increasingly important role.
Reference£º
Patent; ASCENEURON S. A.; QUATTROPANI, Anna; KULKARNI, Santosh S.; GIRI, Awadut Gajendra; KOEK, Johannes Nicolaas; (64 pag.)WO2017/144635; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica