934-34-9, Benzothiazolone is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
6-(4-Nitrobenzoyl)-1,3-benzothiazol-2(3H)-one (1; Table I-B). In a 100 ml flask containing 35.0 g (265 mmol) aluminium chloride, add drop by drop and with magnetic stirring 5.9 ml of dimethylformamide (76 mmol). Continue stirring for 25 minutes, slowly add 5.0 g (33 mmol) of 2(3H)-benzothiazolone and heat to 90 C. Add drop by drop 7.36 g of 4-nitrobenzoyl chloride (40 mmol) and continue to stir at 100-110 C. for 4 hours. Slowly pour the reaction mixture onto ice while stirring vigorously. Add 15 ml of 37% hydrochloric acid and then stir for 15 minutes. Spin out the precipitate then wash with water until the wash water is neutral. Dry the product obtained and recrystallise it in dioxane (5.85 g, 59%). Rf=0.39 (EtOAc/Cyclohexane=4/6): mp 260-265 C.; ir gamma NH 3369 cm-1, CO 1682 cm-1, 1651 cm-1, NO2 1521 cm-1; 1H-NMR (300 MHz, DMSO-d6) delta 7.26 (d, 1H, H4, J4-5=7.8 Hz), 7.72-7.74 (m, 1H, H5), 7.92 (d, 2H, H3′, H5′, J=9.0 Hz), 8.09 (s, 1H, H7), 8.36 (d, 2H, H2′, H6′, J=9.0 Hz), 12.3 (br s, 1H, NH, exchangeable with D2O). Anal. (C14H8N2O4S)
The synthetic route of 934-34-9 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Park, Chang-Ha; Yous, Said; Nativelle-Serpentini, Celine; Seralini, Gilles-Eric; Chang, Soon-Jae; Lesieur, Daniel; US2007/54899; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica