Day: August 20, 2020

2719-23-5, 2-Acetamidothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

STEP B: 3-isopropyl-1,3-dihydro-1-[(2-thiazolyl)-imino]-5-(trifluoromethyl)-furo-[3,4-b]-quinolin-9-ol 10.6 g of N-(2-thiazolyl)-acetamide, 325 ml of tetrahydrofuran and 106 ml of n-butyllithium in hexane titrating 1.4M and 11.4 g of 2-(1-chloro-2-methylpropyl)-8-(trifluoromethyl)-4H-3,1-benzoxazin-4-one of Step A in solution in 80 ml of tetrahydrofuran were reacted by the procedure of Step A of Example 6 of Belgian Pat. No. 896,941 to obtain 13.8 g of 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-beta-oxo-N-(2-thiazolyl)-3-(trifluoromethyl)-benzene propanamide melting at 186 C. 11.65 g of the latter product in 200 ml of tetrahydrofuran and 3.8 g of 4-dimethylaminopyridine were refluxed for 16 hours and the tetrahydrofuran was eliminated under reduced pressure. 200 ml of water were added to the residue, and the pH was adjusted to 1-2 with N hydrochloric acid addition. After separating, washing with water and drying under reduced pressure at 100 C., 10.2 g of 3-isopropyl-1,3-dihydro-1-[(2-thiazolyl)-imino]-5-(trifluoromethyl)-furo-[3,4-b]-quinolin-9-ol melting at 246 to 248 C. were obtained.

As the paragraph descriping shows that 2719-23-5 is playing an increasingly important role.

Reference£º
Patent; Roussel Uclaf; US4735951; (1988); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

298694-30-1, 4-Bromo-2-methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 4-bromo-2-methyl-thiazole (1.5 g, 8.52 mmol), 4-chloropyridin-2- amine (1 .3 g, 10.22 mmol) and CS2003 (6.92 g, 21 .3 mmol) in 1,4 dioxane(30 ml) was degassed with nitrogen for 20 mm. Pd2(dba)3 (0.389 g, 0.42 mmol) and Xantphos (0.24 g, 0.42 mmol) were added and the resulting mixture was stirred at 90 00 for 16 h. When cooled to rt the mixture was filtered through celite, concentrated and purified by preparative HPLC to give the product as a solid (600 mg, 31%). 1H NMR (400 MHz, DMSO-d6) 6 10.15 (s, 1 H), 8.15 (d, 1 H), 7.37 (s, 1 H), 7.03 (d, 1 H), 6.85-6.84 (m, 1 H), 2.61 (s, 3 H). MS ES+ m/z226 [M+H].

The synthetic route of 298694-30-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SPRINT BIOSCIENCE AB; LINDSTROeM, Johan; FORSBLOM, Rickard; GINMAN, Tobias; RAHM, Fredrik; VIKLUND, Jenny; (93 pag.)WO2019/38389; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

106092-09-5, (S)-(-)-2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of carboxylic acid (1 mmol) in CH2Cl2 (10 ml) were added Et3N (2 mmol) and TBTU (1.1 mmol) and the mixture was stirred at room temperature for 15 min. Then amine 1 or 3 (1 mmol)and Et3N (2 mmol) were added and the reaction mixture was stirred at room temperature for 2.5 h. The reaction mixture was diluted with CH2Cl2 (15 ml) and washed with saturated aqueous NaHCO3 solution (2×15 ml). Combined water phases were extracted with CH2Cl2 (1 20 ml). Combined organic phases weredried over Na2SO4, filtered and the solvent removed under reduced pressure.

As the paragraph descriping shows that 106092-09-5 is playing an increasingly important role.

Reference£º
Article; Hodnik, ?iga; Toma?i?, Tihomir; Ma?i?, Lucija Peterlin; Chan, Fiona; Kirby, Robert W.; Madge, David J.; Kikelj, Danijel; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 154 – 164;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2933-29-1,2-Amino-4,5,6,7-tetrahydrobenzothiazole,as a common compound, the synthetic route is as follows.

General procedure: A cold solution of NaNO2 in 5mL water was added dropwise tothe well-cooled solution of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole-2-amine (1) in 10mL HCl and stirred for 2 h at 0-5 C. Aftercompletion of the diazotization, the resulting diazonium salt solutionwas slowly added to the ice-cold solution of coupling components(3a-3e) in acetic acid and stirred for another 2 h at thesame temperature. The pH of the reaction mixture was maintainedat 5e6 by adding the required volume of the saturated solution ofsodium bicarbonate. Further, the obtained colored precipitate ofthe respective azo dyes (4a-4e) was separated by filtration, washedwith distilled water, dried and recrystallized from ethanol. Theschematic representation of the synthesis of azo dyes was presentedin Scheme 1.

The synthetic route of 2933-29-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Maliyappa; Keshavayya; Mallikarjuna; Murali Krishna; Shivakumara; Sandeep, Telkar; Sailaja, Krishnamurty; Nazrulla, Mohammed Azeezulla; Journal of Molecular Structure; vol. 1179; (2019); p. 630 – 641;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.383865-57-4,4-Methoxy-7-morpholinobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

3-Hydroxymethyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide Using 4-methoxy-7-morpholin-4-yl-benzothiazol-2-ylamine and 3-hydroxymethyl-piperidine the title compound was obtained as white solid (69%). MS: m/e=436 (M+H+).

The synthetic route of 383865-57-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Alanine, Alexander; Flohr, Alexander; Miller, Aubry Kern; Norcross, Roger David; Riemer, Claus; US2002/45615; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

81569-44-0, Methyl 4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution of methyl 3-methylthiophene-2-carboxylate 109a (33 g, 0.211 mol) in dry CH2CI2 (30 mL) was added dropwise to a mixture of aluminum chloride (40 g, 0.297 mol) and dry CH2CI2 (200 mL) at -78 C, under nitrogen. The reaction mixture was stirred for 10 min at – 78 C, and a solution of ieri-butyl chloride (23 mL, 0.211 mol) in dry CH2C12 (30 mL) was added dropwise at -78 C. The reaction mixture was stirred for 1 h at -78 C, gradually allowed to warm to room temperature and stirred for 16 h at room temperature. It was poured on ice and extracted with CH2CI2 (2 x 200 mL). The organic layer was dried over anhydrous Na2S04 and the solvent evaporated under vacuum. The obtained residue was purified by fractional distillation to yield methyl 5-ieri-butyl-3-methylthiophene-2-carboxylate 109b (19 g, 43%) as a light yellow liquid.

81569-44-0 Methyl 4-methylthiazole-5-carboxylate 676432, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy, B.; WO2012/30990; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

302964-20-1, tert-Butyl (5-(chlorocarbonyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 10 mL of THF were added 0.8 g of 2- [(1,1- dimethylethoxy) carbonylamino] -5-carboxylic acid chloride, 0.27 g of (IS) -1-cyclohexylethylamine and 0.80 g of triethylamine, and the mixture was stirred at room temperature for 8 hours. Water was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with an aqueous saturated sodium bicarbonate and saturated brine successively, then dried over magnesium sulfate, and concentrated under reduced pressure. The resultant solid was washed with hexane to obtain 0.94 g of N- [ (IS) -1-cyclohexylethyl] -2- [ (1, 1- dimethylethoxy) carbonylamino] thiazole-5-carboxamide .N- [ (IS) -1-cyclohexylethyl] -2- [(1,1- dimethylethoxy) carbonylamino] thiazole-5-carboxamide1H-NMR (CDCl3) delta: 0.97-1.44 (8H, m) , 1.48-1.81 (15H, m) ,4.00-4.05 (IH, m) , 5.48 (IH, d, J = 8.9 Hz), 7.84 (IH, s), 10.49 (IH, br s) .

As the paragraph descriping shows that 302964-20-1 is playing an increasingly important role.

Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/66790; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3292-77-1,2-Bromo-1-(thiazol-2-yl)ethanone,as a common compound, the synthetic route is as follows.

2-Bromo-l-(l,3-thiazol-2-yl)ethanone (54.2 mg, 0.26 mmol) is added to a solution of (R)-quinuclidin-3-yl 2-(methyl(phenyl)amino)-2-phenylacetate (C75)(92.2 mg, 0.26 mmol) in EtOAc (5 mL). The mixture is stirred at RT overnight. The solvent is evaporated to dryness and the crude is triturated with Et2theta. The yellow solid is collected by filtration (120 mg, 82% yield, bromide salt, mixture of diastereoisomers).1H NMR (300 MHz, DMSO-^6) ppm: 8.39 (d, 1 H), 8.25 (d, 1 H), 7.32 – 7.50 (m, 5 H), 7.19 – 7.30 (m, 2 H), 6.84 – 7.00 (m, 2 H), 6.67 – 6.85 (m, 1 H), 5.97 (s, 1 H), 5.23 – 5.38 (m, 1 H), 5.19 and 5.20 (s, 2 H), 4.04 – 4.29 (m, 1 H), 3.44 – 3.82 (m, 5 H), 2.76 and 2.77 (s, 3 H), 2.24 – 2.36 (m, 1 H), 1.45 – 2.13 (m, 4 H); LC-MS (ESI POS): 476.0 (MH+).

3292-77-1 2-Bromo-1-(thiazol-2-yl)ethanone 2795212, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele; WO2010/72338; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.42182-65-0,Benzo[d]thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 6a/6b/6c/7a/7b/7c (1 mmol),benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1Hbenzimidazol-2-amine (2c)/(benzoxazol-2-yl)methanamine(3a)/(benzothiazol-2-yl) methanamine (3b)/(1H-benzimidazol-2-yl)methanamine (3c) (1.1 mmol), dry ethanol (4 ml)and a catalytic amount of methanesulfonic acid (0.2 ml) wasrefluxed for 6-7 h. The contents of the flask were cooledand diluted with water (15 ml). The separated solid wasfiltered, washed with water, dried and recrystallized from 2-propanol.

The synthetic route of 42182-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 82B 3-(2-Methoxyethyl)-4,5-dimethyl-3H-thiazol-2-ylideneamine hydrobromide A mixture of 4,5-dimethylthiazol-2-ylamine (9.0 g, 70 mmol) and 2-bromoethyl methyl ether (7.9 mL, 84 mmol) were heated at 85 C. for 12 hours. The mixture was cooled to ambient temperature and then triturated with isopropanol. The solid was collected by filtration and dried under vacuum to provide 10 g (56%) of the title compound. 1H NMR (DMSO-d6, 300 MHz) delta ppm 2.17 (s, 3H), 2.19 (s, 3H), 3.25 (s, 3H) 3.56 (t, J=5.1 Hz, 2H) 4.16 (t, J=5.1 Hz, 2H) 9.41 (s, 1H).

2289-75-0 4,5-Dimethylthiazol-2-amine 73238, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; US2008/242654; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica