81569-44-0, Methyl 4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A solution of methyl 3-methylthiophene-2-carboxylate 109a (33 g, 0.211 mol) in dry CH2CI2 (30 mL) was added dropwise to a mixture of aluminum chloride (40 g, 0.297 mol) and dry CH2CI2 (200 mL) at -78 C, under nitrogen. The reaction mixture was stirred for 10 min at – 78 C, and a solution of ieri-butyl chloride (23 mL, 0.211 mol) in dry CH2C12 (30 mL) was added dropwise at -78 C. The reaction mixture was stirred for 1 h at -78 C, gradually allowed to warm to room temperature and stirred for 16 h at room temperature. It was poured on ice and extracted with CH2CI2 (2 x 200 mL). The organic layer was dried over anhydrous Na2S04 and the solvent evaporated under vacuum. The obtained residue was purified by fractional distillation to yield methyl 5-ieri-butyl-3-methylthiophene-2-carboxylate 109b (19 g, 43%) as a light yellow liquid.
81569-44-0 Methyl 4-methylthiazole-5-carboxylate 676432, athiazole compound, is more and more widely used in various.
Reference£º
Patent; GILEAD CONNECTICUT, INC.; GENENTECH, INC.; CURRIE, Kevin S.; WANG, Xiaojing; YOUNG, Wendy, B.; WO2012/30990; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica