Day: August 24, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20358-03-6,2-Amino-5-bromobenzothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromo-1,3-benzothiazol-2-amine (200 mg, 0.87 mmol, 1.0 eq.) and 4-nitrophenyl 5?bromo-2-hydroxybenzoate (325 mg, 0.96 mmol, 1.1 eq.) was melted at 200¡ãC for 80 minutes. The solid was taken up in ethanol and heated at reflux temperature during 20 minutes. The solid product was filtered and then, triturated with diethyl ether to afford26bas an off-white solid (160 mg, 43 percent).1H NMR(DMSO-d6, 600 MHz):d(ppm): 7.03 (1H, d, J3-4= 8.7Hz, H3), 7.52 (1H, dd, J6?-7?= 8.5Hz, J6?-4?= 1.4Hz, H6?), 7.64 (1H, dd, J4-3= 8.7Hz, J4-6= 2.3Hz, H4), 7.94 (1H, bs, H4?), 8.00 (1H, d, J7?-6?= 8.5Hz, H7?), 8.04 (1H, d, J6-4= 2.3Hz, H6), 12.25 (1H, bs, amide H).13C NMR (DMSO-d6, 150 MHz):d(ppm): 111.0 (C5), 119.7 (C5?), 119.9 (C7a?), 120.1 (C3), 124.5 (C7?), 127.1 (C6?), 132.8 (C6), 137.3 (C4).HRMS calcd for C14H979Br81Br N2O2S: m/z = 428.8726, found: 428.8774.

The synthetic route of 20358-03-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Labriere, Christophe; Gong, Huansheng; Finlay, B. Brett; Reiner, Neil E.; Young, Robert N.; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1 – 13;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.

General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and 2-imino-1,3-thiazolidin-4-one (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.

556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.

Reference£º
Article; Esmaeili, Abbas Ali; Zangouei, Mahdieh; Fakhari, Ali Reza; Habibi, Azizollah; Tetrahedron Letters; vol. 53; 11; (2012); p. 1351 – 1353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61323-26-0, Ethyl 5-methylthiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N, N’-dimethyl-3,3′-dithiodipropionamide, ethyl acetate and potassium iodide were continuously fed into the preheating system at a ratio of 100: 500: 0.2,Preheat the mixture to 40 ~ 45 C.The solid-liquid mixture is uniformly mixed into a slurry through a static mixer, and then sent to a pipeline reactor for reaction. The pipeline reactor is fed with chlorine gas at multiple points and controlled by a temperature control system.The reaction temperature is 50 to 55 C, and the residence time is 15 minutes.After the reaction liquid from the pipeline reactor is separated by gas and liquid, it enters the post-processing system.After the post-treatment process, a 14% CMIT / MIT aqueous solution was obtained, the chlorine ratio was 3: 1, and the yield was 95%.During the process, all hydrogen chloride gas enters the hydrogen chloride absorption system to produce by-product hydrochloric acid.

As the paragraph descriping shows that 61323-26-0 is playing an increasingly important role.

Reference£º
Patent; Dalian Baiao Chemical Co., Ltd.; Zhao Jianxin; Han Yi; Chen Qi; Qiang Xinxin; Yang Zhaohui; Qu Zhenbin; Zhang Yulong; Yang Mingcheng; Liu Shukuan; Liu Fang; Gu Zhenpeng; (7 pag.)CN110483438; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-48-8, 2-Bromo-5-nitrothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(1) 1-(5-Nitrothiazol-2-yl)piperazine To a solution of piperazine (18.2 g) and potassium carbonate (12.6 g) in acetonitrile (150 ml) was added 2-bromo-5-nitrothiazole (14.7 g) at 40¡ã C. and the mixture was stirred at 60¡ã C. for 40 min. The reaction mixture was poured into water and extracted with chloroform. The extract was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated to give a brown solid (11.2 g). The obtained brown solid was purified by silica gel column chromatography (developing solvent; chloroform_methanol=9:1) to give the title compound (4.8 g) as yellow crystals. 1H-NMR(DMSO-d6)(delta: 2.80(4H, t, J=5.3 Hz), 3.55(4H, t, J=5.3 Hz), 8.37(1H, s); MS(EI): 214(M+);

As the paragraph descriping shows that 3034-48-8 is playing an increasingly important role.

Reference£º
Patent; Mitsubishi Pharma Corporation; US6455528; (2002); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-(6-Methyl-1 H-indol-3-yl)acetic acid (100 mg, 0.53 mmol) was dissolved in DMF (7mL). 5-Ethylthiazol-2-amine (74.5 mg, 0.58 mmol) and DIPEA (0.18 mL, 0.7mmol) were added. PyBOP (302.5 mg, 0.58 mmol) was added and the reaction was stirred for 16 h at room temperature. The solvent was removed in vacuo. The residue was dis20 solved in EtOAc and washed twice with sat. aq. sodium bicarbonate solution, once withwater and once with sat. aq. sodium chloride solution. The organic phase was evaporated and the residue was purified by flash chromatography (gradient: 20-100% ethyl acetate in n-heptane). The solvent was evaporated and the title compound was obtained as an orange solid (107 mg, 0.36 mmol, 68% yield). UPLO-MS (Positive mode)m/z 300 (M+H). Retention time 1 .525 mm.

39136-60-2 5-Ethylthiazol-2-amine 12737257, athiazole compound, is more and more widely used in various.

Reference£º
Patent; EUROPEAN MOLECULAR BIOLOGY LABORATORY; WILL, David William; REID, George; CHARAPITSA, Iryna; LEWIS, Joe; (118 pag.)WO2018/229195; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56354-98-4, 6-Aminobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Asolution of 2,6-difluoro-3nitropyridine (0.20g. 1.3 mrnol) and &aminobenzo[d]thiazol.-2(3H)-one (0.20 g, 1.2 mmol) in DMF (6 mL) was heated at 100 C for 1 h. Benzaldehyde (0.15 g, 1.4 mmol) was added to the mixture and the reaction was let stir for 30 mm followed by addition of sodium dithionite (0.65g. 3.8 mmoi). After 12 hat 100 C the reaction was cooled, diluted with EtOAc (50mL), and washed with H20 (25 mL x 3). The organic layer was dried (Na2504) and concentrated in vaeuo. Purification FCC. Si02, EtOAc/hexanes) afforded the title compound (0.10 g, 22%). MS (ESfl: mass caicd. for C,9H, ,FN4OS, 362.1; miz found, 363.1 [M+Hf. ?H NMR (400 MHz, DMSO-d6) oe 12.19 (br s, 11-I), 8.39 (dd, ,j:::: 8.5, 7.2 Hz. ifI). 7.79 (d, J::: 2.1 Hz, IH), 7.60 7.53 (m, 21-I), 7.48 — 7.37 (m. 31:1), 7.31 (dd, J: 8.4. 2.1 Fiz, 11-I), 7.24 (d, ,j:::: 8.4 Hz, IH), 7,14 (dd, J::::8.5.0.8Hz, 11-I).

56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3364-80-5, Thiazole-4-carboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[623] Example 158 – 3-ri-Methyl-5-(4-methyl-cvclohexyl)-l,2,3,6-tetrahydro-pyridin-4-yl1-5-r4-; [624] A mixture of 4-bromobenzyl bromide (1.00 g, 4.00 mmol) and triphenylphosphine (1.70 g, 6.00 mmol) in toluene (10 mL) was stirred at 80 ¡ãC overnight. The reaction mixture wasconcentrated, followed by sonication in hexane, filtration, and a subsequent hexane wash gave a white solid, which was dried in vacuo. This white solid (906 mg, 1.77 mmol) was dissolved in THF (10 mL), cooled to 0 ¡ãC, and lithium hexamethyl disilazide (1 M) in THF (1.95 mL, 1.95 mmol) was added. After 0.5 hr, thiazole-4-carboxaldehyde (200 mg, 1.77 mmol) was added, the ice bath was removed, and the mixture stirred for 0.5 hr. The reaction mixture was quenched by the addition of water, extracted with EtOAc (2×30 mL), the organic layer was washed with brine, dried over MgS04, concentrated and filtered through a silica plug using 30percent -100percent EtOAc/hexane to give 158A as a clear oil. MS calcd: M+H)+ = 267. + = 267.

3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.

Reference£º
Patent; COCRYSTAL DISCOVERY, INC.; LEE, Sam, Sk; SHEN, Wang; ZHENG, Xiaoliang; JACOBSON, Irina, C.; WO2012/83105; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

35272-15-2, 2-Methylthiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate 32lambda/-(6-Bromo-1H-indazol-4-yl)-2-methyl-1,3-thiazole-4-carboxamide 2-Methyl-1 ,3-thiazole-4-carboxylic acid (4.59g) (available from Maybridge), HATU (13.41g) and DIPEA (16.80ml) were stirred in DMF (140ml) for 30min at 2O0C. 6-Bromo- 1 H-indazol-4-amine (3.4g) (available from Sinova) was added and the reaction stirred at 2O0C for 2 days. The solvent was reduced to ~40ml and the reaction mixture was applied across 5×70 g aminopropyl SPE cartridges and left to stand for 3h. The cartridges were eluted with DCM:methanol (1 :1 ) and the combined solvent was evaporated in vacuo. The residue was suspended in DCM:methanol, adsorbed onto Florisil.(R). and purified by chromatography on silica gel (10Og cartridge) eluting with 0 – 15percent gradient of methanol (containing 1percent triethylamine) in DCM over 60min to give title compound (1.02g). LC/MS Rt 0.95min m/z 337 [MH+]. Method B

35272-15-2 2-Methylthiazole-4-carboxylic acid 284728, athiazole compound, is more and more widely used in various.

Reference£º
Patent; GLAXO GROUP LIMITED; WO2009/147188; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13750-63-5,(4-Methylthiazol-2-yl)methanol,as a common compound, the synthetic route is as follows.

Preparation 37; 2-Bromomethyl-5-chloro-thiopheneCool (5-chloro-thiophen-2-yl)-methanol (Preparation 30) (330 mg, 2.22 mmol) to 0 0C and add acetyl bromide (709 mg, 430 muL, 5.76 mmol). Allow to warm to room temperature over 18 h, dilute with EtOAc (10 mL), and cautiously add saturated aqueous NaHCO3 (3 mL). When the carbon dioxide evolution stops, load the mixture onto a Varian Chem Elut CE1005 solid phase extraction cartridge (Varian part number 12198006). Elute with EtOAc, collect, and concentrate about 50 mL to obtain the crude product. Purify on silica gel (12 g) using 0-15% EtOAc/hexanes to afford 250 mg (53%) of the title compound as a yellow oil. MS (EI): 210,212; 1H NMR (CDCl3): delta 6.92 (d, IH, /=3.5 Hz), 6.78 (d, IH, /=4.0 Hz), 4.66 (s, 2H).

13750-63-5 (4-Methylthiazol-2-yl)methanol 17750909, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ELI LILLY AND COMPANY; WO2007/2181; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.45865-42-7,5-(tert-Butyl)-4-methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 5-tert-butyl-4-methylthiazole-2-ylamine (1.5 g, 8.8 mmol) and 2-bromoethyl methyl ether (0.91 mL, 9.7 mmol) was warmed to 85 0C and allowed to stir for 24 hours. The crude material was dissolved in ~5 mL of a 1 :1 mixture OfCH2Cl2 and CH3OH and a small amount of silica gel was added. This mixture was concentrated to dryness and the residue was purified via flash column chromatography (SiO2, 9:1 :0.1 CH2Cl2 :CH3OH:NH4OH) to afford the title compound (1.0 g, 4.4 mmol, 50% yield). 1H NMR (300 MHz, CD3OD) delta ppm 1.41 (s, 9 H) 2.38 (s, 3 H) 3.35 (s, 3 H) 3.66 (t, J=4.70 Hz, 2 H) 4.16 (t, J=4.70 Hz, 2 H); MS (DCI/NH3) m/z 229 (M+H)+

45865-42-7 5-(tert-Butyl)-4-methylthiazol-2-amine 1081536, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ABBOTT LABORATORIES; WO2009/67613; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica