56354-98-4, 6-Aminobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Asolution of 2,6-difluoro-3nitropyridine (0.20g. 1.3 mrnol) and &aminobenzo[d]thiazol.-2(3H)-one (0.20 g, 1.2 mmol) in DMF (6 mL) was heated at 100 C for 1 h. Benzaldehyde (0.15 g, 1.4 mmol) was added to the mixture and the reaction was let stir for 30 mm followed by addition of sodium dithionite (0.65g. 3.8 mmoi). After 12 hat 100 C the reaction was cooled, diluted with EtOAc (50mL), and washed with H20 (25 mL x 3). The organic layer was dried (Na2504) and concentrated in vaeuo. Purification FCC. Si02, EtOAc/hexanes) afforded the title compound (0.10 g, 22%). MS (ESfl: mass caicd. for C,9H, ,FN4OS, 362.1; miz found, 363.1 [M+Hf. ?H NMR (400 MHz, DMSO-d6) oe 12.19 (br s, 11-I), 8.39 (dd, ,j:::: 8.5, 7.2 Hz. ifI). 7.79 (d, J::: 2.1 Hz, IH), 7.60 7.53 (m, 21-I), 7.48 — 7.37 (m. 31:1), 7.31 (dd, J: 8.4. 2.1 Fiz, 11-I), 7.24 (d, ,j:::: 8.4 Hz, IH), 7,14 (dd, J::::8.5.0.8Hz, 11-I).
56354-98-4 6-Aminobenzo[d]thiazol-2(3H)-one 6453329, athiazole compound, is more and more widely used in various.
Reference£º
Patent; JANSSEN PHARMACEUTICA NV; BERRY, Cynthia G.B.; CHEN, Gang; JOURDAN, Fabrice Loic; LEBOLD, Terry Patrick; LIN, David Wei; PENA PINON, Miguel Angel; RAVULA, Suchitra; SAVALL, Bradley M.; SWANSON, Devin M.; WU, Dongpei; ZHANG, Wei; AMERIKS, Michael K.; (407 pag.)WO2016/176460; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica