With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of dimethyl acetylenedicarboxylate (0.14 g, 1 mmol) and 2-imino-1,3-thiazolidin-4-one (3) (0.118 g, 1 mmol) in anhydrous CH2Cl2 (5 mL) was added dropwise a solution of cyclohexyl isocyanide (0.083 g, 1 mmol) in anhydrous CH2Cl2 (3 mL) at rt over 10 min. The reaction mixture was then stirred for 24 h. The solvent was removed under reduced pressure and the residue purified by silica gel (Merck 230-240 mesh) column chromatography using hexane-EtOAc as eluent to yield 4a.
556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.
Reference£º
Article; Esmaeili, Abbas Ali; Zangouei, Mahdieh; Fakhari, Ali Reza; Habibi, Azizollah; Tetrahedron Letters; vol. 53; 11; (2012); p. 1351 – 1353;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica