Brief introduction of 80945-83-1

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

Step B:; A solution of 2-chlorobenzothiazole-6-carbonitrile (14.9 g, 0.077 mol) in DMF (250 ml.) was added drop-wise at 100C to a mixture of anhydrous piperazine (60 g, 0.698 mol) and DMF (30OmL). Then the mixture was stirred for 2 h. Water (1 ,550 ml.) was added and the mixture was extracted with dichloromethane (5 x 500 ml_). The combined organic extracts was washed with water (6 x 500 ml_), dried (Na2SO4), filtered and evaporated to give a residue which was re-crystallised from ethyl acetate. This afforded 10.5 g (56 percent) of 2-(piperazin-1- yl)benzothiazole-6-carbonitrile. A mixture of this piperazine derivative (19.4 g, O.Odeltamol), sodium iodide (1.94 g), triethylamine (9.6 g, 0.095mol) and DMF (8OmL) was heated with stir- ring to give a red liquid. A solution of 2-bromopropane (14.7 g, 0.12mol) in DMF (8OmL) was added drop-wise at 117 0C within in 1 h. The reaction mixture was stirred at 1 10-117 0C for another 3 h and then allowed to cool to room temperature. Water (110 ml.) was added and the mixture was filtered. The filter cake was washed until the filtrate was colourless and then dried. The solid was dissolved in DMF (250 ml.) and filtered to remove a solid residue. Water (1000 ml.) was added to the filtrate with stirring to give a precipitate. The solid was isolated, washed with water and dried to give 9.4 g (41 percent) of 2-(4-lsopropylpiperazin-1-yl)benzo- thiazole-6-carbonitrile.1H-NMR delta 8.25 (s, 1 H), 7.61 (d, 1 H), 7.45 (d, 1 H), 3.55 (t, 4H), 2.68 (m, 1 H), 2.51 (m, 4H), 0.93 (d, 6H).

As the paragraph descriping shows that 80945-83-1 is playing an increasingly important role.

Reference£º
Patent; NOVO NORDISK A/S; WO2007/110364; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica