With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.
To a mixture of ethyl 2-bromo-1 ,3-thiazole-5-carboxylate (1.01 g, 4.29 mmol), K2CO3 (2.0 g, 14.47 mmol) and Pd(Pt-Bu3)2 (280 mg, 0.548 mmol) in 1 ,4-dioxane (8 ml.) and water (1.6 ml.) was added 1 -methyl-5-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1 H-pyrazole (1.76 g, 8.47 mmol) [prepared in Preparation 2]. The reaction was stirred at 120 0C for 45 min in a microwave reactor and cooled to room temperature. The mixture was partitioned between CHCI3 / H2O and the aqueous layer was washed several times with CHCI3. The combined organic fractions were dried over Na2SO4, concentrated, and purified via column chromatography (silica, 0-50%EtOAc/hexanes) affording the title compound (0.7 g, 61%) as a yellow solid: LC-MS (ES) m/z = 238 (M+H)+.
41731-83-3 Ethyl 2-bromothiazole-5-carboxylate 3614103, athiazole compound, is more and more widely used in various.
Reference£º
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/158372; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica