Day: August 27, 2020

41731-83-3, Ethyl 2-bromothiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 5; (R)-2-(2-(1-(4-(1-hydroxyhexyl)phenyl)-5-oxopyrrolidin-2-yl)ethylthio)thiazole-5-carboxylic acid (22); Step 1. Conversion of 10 to 20Ethyl 2-bromothiazole-5-carboxylate (15 muL, 0.10 mmol), tributylphosphine (5 muL, 0.02 mmol), and potassium carbonate (20 mg, 0.15 mmol), were added sequentially to a solution of thioacetate 10 (crude from example 1, step 8, 45 mg, 0.094 mmol) in absolute EtOH (0.38 mL). After stirring overnight at room temperature, the volatiles were removed under a stream of nitrogen. The resulting residue was suspended in EtOAc and then decanted and concentrated in vacuo. The crude residue was purified on 4 g silica (hexanes?EtOAc, gradient) to afford 55 mg (99%) of 20.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Allergan, Inc.; US2008/269498; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 6-[4-(methylsulfonyl)phenyl]-5-phenyl-4-piperazin-1-yl-2-(trifluoromethyl)pyrimidine (0.2 g, 0.43 mmol, prepared according to the procedure described in preparation 2) in dichloroethane (25 ml) was added thiazole-2-carboxaldehyde (0.144 g, 1.3 mmol) under stirring at 37¡ã C. After five minutes, sodium triacetoxy borohydride (0.364 g, 1.72 mmol) was added to reaction mixture and then after 10 minutes, acetic acid (0.1 ml) was added to it. The reaction mixture was stirred for 36 hours under the same conditions. Subsequently the reaction mixture was treated with ethyl acetate:water (1:1, 100 ml) and extracted with ethyl acetate (50 ml*3). The organic layer was washed with brine (100 ml) and dried over anhydrous sodium sulphate. The solid obtained upon evaporation was purified by column chromatography using methanol:dichloromethane (0.5:99.5) as an eluent to afford the title compound (0.1 g, yield 45.6percent). 1H-NMR (CDCl3) delta: 0.88-0.89 (m, 2H), 1.25-1.28 (t, 2H), 1.33-1.38 (t, 2H), 2.85 (s, 6H), 2.97 (s, 3H), 7.04-7.74 (m, 9H). MS m/z: 544.59 (M++1).

10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ORCHID RESEARCH LABORATORIES LIMITED.; US2007/167413; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2516-40-7, 2-Bromobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Chlorobenzothiazole(169 mg, 1 mmol) and EtOH (5 ml), and 3-fluoro-4-hydroxyaniline (127 mg, 1 mmol) was dissolved in and p-TsOH*H2O (30.4 mg, 0.1 mmol) was added and the mixture was stirred for 4 hours at 80 ¡ã C. After checking the completion of the reaction, then cooled at room temperature, then evaporated under reducedpressure to remove the solvent. The concentrated residue was extracted with ethyl acetate (5 ml) and water (3 x 3ml). The extractedorganic layer was filtered and then dried over anhydrous magnesium sulfate, the reduced pressure of the filtrate was evaporated,and purified by column chromatography, and diluted with an equal volume of HCl solution and dried. As a result, 4-(benzo[d]thiazol-2-ylamino)-2-fluorophenol was obtained (222 mg, 75percent yield).

The synthetic route of 2516-40-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Gyeonggi Science & Technology Agency; Koo, Jin Moh; Jung, Kwi Wan; Kim, Soo Mi; Park, Jong Hyun; Noh, Jae Sung; Lee, Jung Heon; Park, Sun Min; Jung, Dae Yeon; Lee, Kwang Nyung; Choe, Joo Hyung; (36 pag.)KR101659952; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

64987-08-2, Ethyl 2-(2-aminothiazol-4-yl)-2-oxoacetate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 96 {2-[2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-oxo-acetic acid ethyl ester A solution of triphenylphosphine (238 mg, 0.91 mmol) in methylene chloride (10 mL) was cooled to 0 C. and then treated with N-bromosuccinimide (183 mg, 1.03 mmol). The reaction mixture was stirred at 0 C. until it was completely dissolved and became light purple in color. The reaction mixture was then treated with 2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid (prepared as in Example 92, 200 mg, 0.61 mmol) and stirred at 0 C. for 20 min and then warmed to 25 C. where it was stirred for 30 min. After such time, the reaction mixture was treated with 2-(aminothiazol-4-yl)-oxo-acetic acid ethyl ester (182 mg, 0.91 mmol) and pyridine (0.088 mL, 1.09 mmol), and the reaction mixture was stirred at 25 C. for 16 h. The reaction was then diluted with water (10 mL) and then extracted with methylene chloride (3*15 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 230-400 mesh, 75/25 hexanes/ethyl acetate) afforded {2-[2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionylamino]-thiazol-4-yl}-oxo-acetic acid ethyl ester (208 mg, 67%) as a clear colorless oil: EI-HRMS m/e calcd for C22H25ClN2O6S2 (M+) 513.0921, found 513.0919.

As the paragraph descriping shows that 64987-08-2 is playing an increasingly important role.

Reference£º
Patent; Hoffman-La Roche Inc.; US6610846; (2003); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2516-40-7,2-Bromobenzothiazole,as a common compound, the synthetic route is as follows.

9-Ethyl-3- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -9H-carbazole (1 g, 3.1 mmol) is dissolved in the THF (20 mL). 2-bromobenzothiazole (0.663 g, 3.1 mmol), Pd (PPh3) 4 (0.179 g, 0.155 mmol), Na2CO3 (0.985 g, 9.3 mmol) and distilled water (4 mL) was added a After 15 hours the 70 degree in a nitrogen atmosphere heated at. After the reaction mixture was poured into distilled water (300 mL) Separate the organic layer with ethyl acetate, dry over MgSO4 and evaporate solvents. Column with ethyl acetate / hexane: separate the compound (3) by the (1 2) as a developing solvent to obtain the compound (2) to 65percent.

As the paragraph descriping shows that 2516-40-7 is playing an increasingly important role.

Reference£º
Patent; Pusan National University Industry-Academic Cooperation Foundation; Jin, Sung Ho; Park, Jin Soo; (26 pag.)KR101481147; (2015); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34259-99-9, 4-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. 4-Neopentylthiazole. 4-Bromothiazole (1.98 g, 12.1 mmol) was covered with a 0.5 M solution of neopentylzinc iodide in THF (96 mL, 48.2 mmol). Pd2dba3.CHCI3 (624 mg, 0.603 mmol) and 2(-di-te/t-butylphosphine)biphenyl (720 mg, 2.41 mmol) were added and the reaction mixture was placed in an oil bath pre-heated to 70 ¡ãC. The resulting solution was allowed to stir for 24 h at 70 ¡ãC. The resulting mixture was cooled to room temperature and concentrated under vacuum and the residue was dissolved in ethyl acetate (100 mL) and subsequently washed with aqueous NaOH (2 x 40 mL, 3N). The organic phase was then dried (Na2SO4), filtered, concentrated under vacuum and the residue was purified on a silica gel column (eluant hexane to hexane/ethyl acetate 8/2) to give 4-neopentylthiazole (1.42 g, 75percent), retention time (min) = 1.198, method [1], MS(ESI) 156.1 (M+H).

As the paragraph descriping shows that 34259-99-9 is playing an increasingly important role.

Reference£º
Patent; ELAN PHARMACEUTICALS, INC.; WO2007/47306; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

To a solution of n-BuLi (8.4 ml, 1.6 mol/l, 13.4 mmol) in THF (30 mL) was added 2-bromothiazole (377 mg, 2.12 mmol) dropwise under nitrogen atmosphere at -70¡ã C., and the mixture was stirred at the temperature for 1 h. Then DMF (1.4 ml, 18.3 mmol) was added into the solution dropwise under nitrogen atmosphere at -70¡ã C. The resulting mixture was stirred at the temperature for 1 h. Then the mixture was quenched with aqueous saturated ammonium chloride, diluted with ethyl acetate and water, and the phases were separated. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated to give yellow oil. The yellow oil was dissolved in methanol (15 ml), cooled to -60¡ã C., and sodium borohydride (463 mg, 12.2 mmol) was added portionwise under nitrogen atmosphere. The mixture was stirred at the temperature for 1 h. The reaction was quenched with acetone and concentrated. The residue was diluted with ethyl acetate and water, and the phases were separated. The organic layer was dried over sodium sulfate, filtered and concentrated, then purified by silica gel chromatography eluting with petroleum/ethyl acetate=3:1 to give thiazol-2-ylmethanol (230 mg, 16.4percent yield) as brown oil. LCMS MH+ 116.

10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HYDRA BIOSCIENCES, INC.; Chenard, Bertrand L.; Gallaschun, Randall J.; Kimball, Spencer David; US2014/275528; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Referential Example 12: thiazole-2-methanol While stirring under ice cooling, sodium borohydride (242 mg, 6.40 mmol) was added to a methanol (10 ml) solution of 2-formylthiazole (483 mg, 4.27 mmol).. After completion of the reaction was confirmed, water was added to the reaction mixture.. The resulting mixture was concentrated under reduced pressure.. Water and ethyl acetate were added to the residue to separate the organic layer.. The organic layer was washed with brine and then dried over anhydrous sodium sulfate.. After filtration, the filtrate was concentrated under reduced pressure.. The residue was subjected to chromatography on a silica gel column.. The fraction obtained from the hexane:ethyl acetate (=1:1) elude was concentrated under reduced pressure, whereby the title compound (324 mg, 66percent) was obtained as a white solid.1H-NMR (400MHz, CDCl3) delta: 3.30-3.70(1H,m), 5.14(2H,s), 7.32(1H,d,J=3.4Hz), 7.74(1H,d,J=3.2Hz). MS (m/z): 116 (M++H).

The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1466898; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185613-91-6,4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

(Benzo [d] [1,3] dioxol-5-yl) thiazol-2-amine (2)(1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) were dissolved in THF (15 ml) and reacted at room temperature for 1 hour under a nitrogen stream. Benzyl bromide (1.17 g, 6.82 mmol) was then slowly added dropwise at room temperature and allowed to react for 10 minutes. After the reaction was completed, the reaction mixture was concentrated under reduced pressure, dissolved in ethyl acetate, and saturated NaHCO 3 solution was added thereto. The ethyl acetate layer was separated, dried over anhydrous Na2SO4 and then purified by column chromatography (Ethyl acetate: Hexane = 1: 5) to obtain Compound 1a. Yield: 21.2%

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica