With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59608-97-8,4-(Chloromethyl)thiazol-2-amine hydrochloride,as a common compound, the synthetic route is as follows.
Example 15; (a) To a solution of 3-methyluracil (25 mg, 0.2 mmol) in 0.2 mL DMSO was added NaH (8 mg 60percent oil dispersed, 0.2 mmol). After H2 evolution ceased, 2-amino-4-(chloromethyl)thiazole hydrochloride (15 mg, 0.08 mmol, prepared according to Sprague et al J. Am. Chem. Soc. 1946, 2155; 2158) in 0.2 mL DMSO was added and the reaction was stirred for 3 hr at rt. The reaction was purified directly by HPLC to give 16 mg (84percent) of the N-substituted uracil 15a. MS found: (M+H)+=239.
59608-97-8 4-(Chloromethyl)thiazol-2-amine hydrochloride 73228, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Sheppeck, James; Dhar, T.G. Murali; Doweyko, Lidia; Gilmore, John; Weinstein, David; Xiao, Hai-Yun; Yang, Bingwei V.; Doweyko, Arthur M.; US2006/154973; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica