With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.74537-49-8,2-(Methylthio)benzo[d]thiazol-6-ol,as a common compound, the synthetic route is as follows.,74537-49-8
Step 1. Preparation of 6-(2-chloropyridin-4-yloxy)-2-(methylthio)benzo[d]thiazole To the mixture of 2-(methylthio)benzo[d]thiazol-6-ol (1 g, 5.08 mmol) and cesium carbonate (4.55 g, 14 mmol) in 15 ml of NMP was added 2-chloro-4-fluoropyridine (1.32 mg, 10 mmol). The reaction mixture was stirred at 55 C. for overnight. The reaction mixture was poured into 80 ml of aq. saturated NaHCO3 and extracted with ethyl acetate (2*150 ml). The combined organic layers were washed with aq. 0.1M NaHSO4 (60 ml), water (2*60 ml) and brine (60 ml), then dried over MgSO4, filtered and evaporated in vacuo to give 6-(2-chloropyridin-4-yloxy)-2-(methylthio)benzo[d]thiazole (1.72 g) as brown oil that carried on to next step without purification. ES/MS m/z 308.9 (MH+).
The synthetic route of 74537-49-8 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Novartis AG; US2008/45528; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica