Day: August 31, 2020

74531-15-0, 4,5-Dimethylthiazole-2-carbaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Representative procedure for the conversion of thiazole-2-carbaldehyde derivatives into (1,3-thiazol-2-yl)methylamine derivatives. Under argon, a solution of 4,5-dimethyl-1,3-thiazole-2-carbaldehyde (644.9 mg, 4.57 mmol), hydroxylamine hydrochloride (648.1 mg, 9.143 mmol) and sodium methoxide (493.7 mg, 9.14 mmol) in ethanol (9 mL) was stirred at room temperature overnight. The white solid was filtered off, rinsed with methanol and the solution was evaporated. The crude oxime was dissolved in acetic acid (25 mL), zinc dust (1.8 g, 27.5 mmol) was added portionwise at room temperature and the reaction mixture was stirred at room temperature for 3 hours. The mixture was then filtered over a pad of celite and rinsed with methanol. Toluene was added and the filtrate was concentrated. An aqueous solution of ammonium chloride was added, the solution was acidified to pH = 2 with hydrochloric acid 1N and extracted with diethyl ether and ethyl acetate. These organic layers were discarded. The aqueous layer was basified with aqueous sodium hydroxide to pH = 10, and then extracted with diethyl ether and ethyl acetate. Combined organic extracts were dried over sodium sulfate, filtered and evaporated to give crude (4,5-dimethyl-1,3-thiazol-2-yl)methylamine (321.7 mg, 49%) as a pale yellow oil which was used in the next steps without purification. ESI-MS m/z 143 (M+ H)+., 74531-15-0

As the paragraph descriping shows that 74531-15-0 is playing an increasingly important role.

Reference£º
Patent; Mutabilis; EP2141164; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

185613-91-6, 4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine(2) (1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) to THF (15 ml) todissolved and then allowed to react at room temperature for 1 hour under a nitrogen stream. After dropwise addition of 2-chlorobenzylbromide (1.40 g, 6.82 mmol) slowly at room temperature and reacted for 10 minutes. After the reaction wasfinished, it was concentrated under reduced pressure and extracted three times into a saturated solution of NaHCO3 isdissolved in ethyl acetate. The ethyl acetate layer was separated and dried with anhydrous Na2SO4, then purified by columnchromatography (Ethyl acetate: Hexane = 1: 5) to give the compound 1e to give. Yield 17.6%, 185613-91-6

As the paragraph descriping shows that 185613-91-6 is playing an increasingly important role.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

34272-64-5, 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Each resin from Step 3 was distributed into 24 fritted syringes (Torvig, 50 mg each, 50 mumol), for a total of 96 syringes, and was swelled in NMP (1 mL) for 30 min. The solvent was removed by filtration. Twenty-four solutions of the building blocks listed below (10 mmol each) and DIBA (3.5 mL, 20 mmol) in NMP (10 mL) were prepared. 3 mL of the 24 solutions was added to the 24 syringes for each resin from Step 3, accordingly. The suspensions were then shaken for 20 h on a Titer Plate Shaker. The reaction mixture was filtered and washed 5 times with methylene chloride (5 mL), 3 times with THF (5 mL), 3 times THF/H2O (3/1 v/v, 5 mL), and 3 times with THF (5 mL). The resins were then dried overnight under vacuum., 34272-64-5

34272-64-5 2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid 3035180, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Kong, Xianqi; Wu, Xinfu; Valade, Isabelle; Gervais, Francine; US2006/167057; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

78364-55-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: The mixture of 6-fluoro-2-hydrazinylbenzo[d]thiazole (2) (0.01 mol) and benzalde-hyde/substituted benzaldehyde (0.01 mol) was reuxed in ethanol (15 ml) at 70?80 ¡ãC for 3 h. The separated product obtained was ltered off, washed withdistilled water and recrystallized from methanol to give the correspondinghydrazone. The product obtained was further dissolved in acetic acid (20 ml) atroom temperature followed by the addition of sodium acetate (0.5 g). Bromine(2 mmol) in acetic acid (10 ml) was added dropwise to the reuxing reactionmixture. After 1 h, the mixture was poured onto crushed ice (100 g). The precipitateobtained was ltered off and crystallized from ethanol-dimethylformamide (1:1) togive crystals of (3a?3t).

As the paragraph descriping shows that 78364-55-3 is playing an increasingly important role.

Reference£º
Article; Kukreja, Sharu; Sidhu, Anjali; Sharma, Vineet K.; Research on Chemical Intermediates; vol. 42; 12; (2016); p. 8329 – 8344;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 2-amino-4,5-dimethylthiazole (1 ,0 g, 7 8 mmol) and (bromomethyl)cyclobutane (0.88 mL, 7.8 mmol) was warmed to 85 0C and stirred for 18 hours. The mixture was cooled to ambient temperature and the residue was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2 : methanol : NH4OH) to afford the title compound. MS (DCI/NH3) m/z l97 (M+H)+, 2289-75-0

As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/140439; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.

In a 50 ml round bottom flask, 8 ml of anhydrous diethyl ether and 0.311 ml (2.2 mmol) of diisopropylamine were added and the solution was cooled to -60C.Then, 2.5 N n-hexane solution of BuLi (2.2 mmol) was added dropwise to the upper reaction system, and the reaction system was warmed to 0 C. and stirred for 15 minutes. Then, sclareolide(500 mg, 2.0 mmol) was added dropwise thereto at -60 C. Ether solution,The reaction mixture was stirred for a further 40 min and then a solution of 2-acetylthiazole (254.3 mg, 2.0 mmol) in diethyl ether was added dropwise to the upper reaction system. The reaction system is stirred at this temperature for 50 min and quenched with water.The organic layer was separated, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give CYL-2-QX-3A in a yield of 60.0%.

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sichuan China National Tobacco Industry Co., Ltd.; Chongqing China National Tobacco Industry Co., Ltd.; Tao Feiyan; Yang Wenmin; Feng Guanglin; Dai Ya; Li Chaorong; Ding Wei; Wang Yao; Zhou Sheng; Zhou Zhigang; Qiu Guangming; Liu Rucan; Zhang Ting; (11 pag.)CN105061418; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1747-60-0,2-Amino-6-methoxybenzothiazole,as a common compound, the synthetic route is as follows.

The starting material 2-bromo-6-methoxy-benzothiazole is prepared by using a PEG- assisted Sandmeyer reaction of the commercially available 2-amino-6-methoxy- benzothiazole according to a literature procedure (N. Suzuki et al., Chemistry Express 1992, 7, 717).

1747-60-0, As the paragraph descriping shows that 1747-60-0 is playing an increasingly important role.

Reference£º
Patent; NOVARTIS AG; WO2008/89933; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170961-15-6,tert-Butyl thiazol-2-ylcarbamate,as a common compound, the synthetic route is as follows.

General procedure: n-BuLi (2.5M in THF, 1.4equiv) was added drop wise to a mixture of compound 1a or 1b (1equiv) and aldehyde (1.2equiv) in THF (?20mL) at -78C for 2h. The reaction was quenched by adding a saturated aqueous solution of NH4Cl, extracted with EtOAc, washed with water and then brine. The organic phase was dried over anhydrous Na2SO4, evaporated, and the residue was purified by silica gel column chromatography, 170961-15-6

The synthetic route of 170961-15-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Khalil, Ahmed; Edwards, Jessica A.; Rappleye, Chad A.; Tjarks, Werner; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 532 – 547;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

42182-65-0, Benzo[d]thiazol-2-ylmethanamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of (4-chloro-6-methylpyrimidin-2-yl)aminosulfonyl chloride (8) (1 mmol), benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1H-benzimidazol-2-amine (2c)/(benzoxazol-2-yl) methanamine (3a)/(benzothiazol-2-yl)methanamine (3b)/(1H-benzimidazol-2-yl)methanamine (3c), (2.2 mmol), dry ethanol (8 ml) and acatalytic amount of methanesulfonic acid (0.4 ml) wererefluxed for 3-5 h. The contents of the flask were cooledand diluted with water (25 ml). The separated solid wasfiltered, washed with water, dried and recrystallized from 2-propanol.

42182-65-0, 42182-65-0 Benzo[d]thiazol-2-ylmethanamine 350414, athiazole compound, is more and more widely used in various.

Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.399-74-6,2-Chloro-6-fluorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: Examples 103 and 104: N-i4,4-Difluoro-2-r(6-fluoro-l,3-benzothiazol-2- yl)amino]cyclopentyl}-2-(2 -l,2,3-triazol-2-yl)benzamide To a solution of N-(2-amino-4,4-difluorocyclopentyl)-2-(2H-l,2,3-triazol-2-yl)benzamide hydrochloride (Intermediate 28; 120 mg, 0.349 mmol) in dry DMSO (1.2 ml) was added 2-chloro-6-fluoro-l,3-benzothiazole (CAS number 399-74-6; 72 mg, 0.384 mmol) and DIPEA (183 mu, 1.047 mmol). The reaction was sealed and stirred at 140 C in a sand bath for 17 hours. The reaction was partitioned between ethyl acetate and water, washing with water, filtered through a hydrophobic frit and concentrated in vacuo. The crude product was then purified by column chromatography (basic silica, 0-100 % ethyl acetate / petrol). The racemic mixture was then purified by SFC to give two enantiomers (Enantiomer 1/Example 103 and Enantiomer 2/Example 104) of the title compound.Example 103 (Enantiomer 1)1H NMR (400 MHz, OCM-d2) delta ppm 2.02 – 2.28 (m, 2 H), 2.72 – 2.98 (m, 2 H), 4.19 – 4.43 (m, 2 H), 6.91 – 7.14 (m, 1 H), 7.20 – 7.35 (m, 3 H), 7.36 – 7.42 (m, 1 H), 7.44 – 7.51 (m, 1 H), 7.52 – 7.60 (m, 1 H), 7.67 (s, 2 H), 7.74 – 7.84 (m, 1 H) MS ES+: 459Example 104 (Enantiomer 2)1H NMR (400 MHz, OCM-d2) delta ppm 2.02 – 2.28 (m, 2 H), 2.72 – 2.98 (m, 2 H), 4.19 – 4.43 (m, 2 H), 6.91 – 7.14 (m, 1 H), 7.20 – 7.35 (m, 3 H), 7.36 – 7.42 (m, 1 H), 7.44 – 7.51 (m, 1 H), 7.52 – 7.60 (m, 1 H), 7.67 (s, 2 H), 7.74 – 7.84 (m, 1 H)MS ES+: 459, 399-74-6

399-74-6 2-Chloro-6-fluorobenzo[d]thiazole 2049870, athiazole compound, is more and more widely used in various.

Reference£º
Patent; TAKEDA CAMBRIDGE LIMITED; TAKEDA PHARMACEUTICAL COMPANY LIMITED; FIELDHOUSE, Charlotte; GLEN, Angela; ROBINSON, John Stephen; FUJIMOTO, Tatsuhiko; WO2015/55994; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica