With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.
In a 50 ml round bottom flask, 8 ml of anhydrous diethyl ether and 0.311 ml (2.2 mmol) of diisopropylamine were added and the solution was cooled to -60C.Then, 2.5 N n-hexane solution of BuLi (2.2 mmol) was added dropwise to the upper reaction system, and the reaction system was warmed to 0 C. and stirred for 15 minutes. Then, sclareolide(500 mg, 2.0 mmol) was added dropwise thereto at -60 C. Ether solution,The reaction mixture was stirred for a further 40 min and then a solution of 2-acetylthiazole (254.3 mg, 2.0 mmol) in diethyl ether was added dropwise to the upper reaction system. The reaction system is stirred at this temperature for 50 min and quenched with water.The organic layer was separated, washed with saturated sodium chloride, dried over anhydrous sodium sulfate, filtered, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography to give CYL-2-QX-3A in a yield of 60.0%.
24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Sichuan China National Tobacco Industry Co., Ltd.; Chongqing China National Tobacco Industry Co., Ltd.; Tao Feiyan; Yang Wenmin; Feng Guanglin; Dai Ya; Li Chaorong; Ding Wei; Wang Yao; Zhou Sheng; Zhou Zhigang; Qiu Guangming; Liu Rucan; Zhang Ting; (11 pag.)CN105061418; (2017); B;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica