Some tips on 2289-75-0

As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2289-75-0,4,5-Dimethylthiazol-2-amine,as a common compound, the synthetic route is as follows.

A mixture of 2-amino-4,5-dimethylthiazole (1 ,0 g, 7 8 mmol) and (bromomethyl)cyclobutane (0.88 mL, 7.8 mmol) was warmed to 85 0C and stirred for 18 hours. The mixture was cooled to ambient temperature and the residue was purified via column chromatography (SiO2, 10% methanol in ethyl acetate then 9:1:0.1 CH2Cl2 : methanol : NH4OH) to afford the title compound. MS (DCI/NH3) m/z l97 (M+H)+, 2289-75-0

As the paragraph descriping shows that 2289-75-0 is playing an increasingly important role.

Reference£º
Patent; ABBOTT LABORATORIES; WO2007/140439; (2007); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica