Month: August 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.79836-78-5,Ethyl 2-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To a stirred solution of ethyl 2-methylthiazole-5-carboxylate (1 eq) in dry THF (5 mL) at 0 Patent; MERCK PATENT GMBH; YU, Henry; LIU-BUJALSKI, Lesley; JOHNSON, Theresa L.; WO2014/159234; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

247037-82-7, Thiazole-2-carboximidamide hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A 1000 L glass-lined reactor equipped with mechanical stirrer, thermometer and nitrogen bubbler was charged 2-chloro-4-fluoro-benzaldehyde (30.8 kg, 194 mol, compound 11-a) andIPA (188.0 kg). To the solution was then added methyl acetoacetate (22.7 kg, 195 mol, compound 11-b) followed by addition of piperidine (1.74 kg, 20.4 mol) and acetic acid (1.32 kg, 22.0 mol). The reaction mixture was then heated to 43 C-47 C and stirred at such temperature for 5 hours. Then to the reaction mixture was added thiazole-2-carboxamidine hydrochloride salt (19.8 kg, 121.0 mol, compound 8-c) followed by addition of triethylamine (20.0 kg, 198.0 mol).The reaction mixture was heated to 80 C – 85 C and stirred for 7 hours. After reaction was completed, the reaction mixture was cooled to 20 C-25 C and then added water (52.0 kg). The resulting suspension was stirred at 20 C-25 C for 2 hours. The solid was collected by centrifuge and washed with isopropanollwater (42 kg, v/v=10/3). The wet solid was dried in vacuum oven to afford Example 11 (35.05 kg, purity: 95.8%, Yield: 79.2%) as yellow solid. MS mle = 366.2[M+H] .

The synthetic route of 247037-82-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHEN, Junli; (58 pag.)WO2017/140750; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5.9 ml (42.3 mmol) of acetic anhydride are added to a solution of 10 g (38. 5 mmol) of 2-amino-5- bromothiazole hydrobromide in 100 ml of dichloromethane and 11 ml (77 mmol) of triethylamine, cooled to 0oC. The reaction medium is stirred for 30 minutes at 0oC and then for 18 hours at room temperature. After addition of water, the pH is adjusted to pH 8 with aqueous 1M sodium hydroxide solution and the reaction medium is extracted with dichloromethane. The dichloro- methane phase is dried over magnesium sulfate, filtered and evaporated. The residue obtained is used in step b without purification.

The synthetic route of 61296-22-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GALDERMA RESEARCH & DEVELOPMENT, S.N.C.; WO2004/113331; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5464-79-9, 2-Amino-4-methoxybenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step A. A solution of AICl3 (5 mmole) in EtSH (10 mL) was cooled to 0 C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole). The mixture was stirred at 0-5 C. for 2 h. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

The synthetic route of 5464-79-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; METABASIS THERAPEUTICS, INC.; US2002/173490; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1024583-33-2,Methyl 2-bromobenzo[d]thiazole-6-carboxylate,as a common compound, the synthetic route is as follows.

4-(((2-Azabicyclo[4.1.0]heptane-5-yl)oxy)methyl)-5-cyclopropyl-3-(2,6-dichlorophenyl) The crude product of the above-mentioned oxazole, 2-bromobenzo[d]thiazolidine methyl-6-carboxylate (240 mg, 0.88 mmol) and cesium carbonate (429 mg,1.32 mmol) was dissolved in DMA (6 mL), and subjected to microwave reaction at 110 C for 40 minutes. After completion of the reaction, 100 mL of water and 30 mL of ethyl acetate were added and the mixture was separated, and the aqueous phase was extracted with ethyl acetate (30 mL¡Á2). concentrate, The residue was subjected to silica gel column chromatography ( petroleum ether: ethyl acetate = 2:1)The product was obtained in 183 mg in two-step yield: 72.9%.

1024583-33-2 Methyl 2-bromobenzo[d]thiazole-6-carboxylate 46911877, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; (39 pag.)CN109575008; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

494769-44-7, tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The intermediate (3) (0.5 g, 0.00217 mol), EDCl (0.622 g, 0.00325 mol), DMAP (0.345 g, 0.0028 mol) were stirred in dichloromethane (6 mL) at 0 C, and the substituted acid (0.00217 mol) were dissolved in (4 mL) of dichloromethane and charged to the reaction mixture and stirred at room temperature for 8 h. The reaction completion was monitored by TLC. Reaction was completed. The reaction mixture was diluted with (10 mL) of dichloromethane, and was washed with 10% NaHCO3 (10 mL). Separated the organic layer and was washed with saturated brine solution (10 mL). The organic layer was dried over sodium sulfate and concentrated the organic layer under reduced pressure to afford compounds 4a-t. The spectral data of compounds 4(a-t) are given below.

The synthetic route of 494769-44-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Karuvalam, Ranjith P.; Haridas, Karickal R.; Nayak, Susanta K.; Guru Row, Tayur N.; Rajeesh; Rishikesan; Kumari, N. Suchetha; European Journal of Medicinal Chemistry; vol. 49; (2012); p. 172 – 182;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57626-37-6,Ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

To the stirred solution of ethyl 6-methylimidazo[2,1-b]thiazole-5-carboxylate (2a) (5.20 g) in ethanol (40 mL) was added 35%aqueous solution of N2H4H2O (40 mL) and refluxed for 3 h. Thereaction mixture was concentrated to half volume and cooled onice bath, the solids formed were filtered and dried in vacuum ovento get 6-methylimidazo[2,1-b]thiazole-5-carbohydrazide (3a)(4.30 g, 89%) as an Off-white solid. ESI-MS showed 197 [M+H]+.

The synthetic route of 57626-37-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Samala, Ganesh; Devi, Parthiban Brindha; Saxena, Shalini; Meda, Nikhila; Yogeeswari, Perumal; Sriram, Dharmarajan; Bioorganic and Medicinal Chemistry; vol. 24; 6; (2016); p. 1298 – 1307;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.64485-82-1,(Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate,as a common compound, the synthetic route is as follows.

Example 4 Preparation of Ethyl (2Z)-2-(2-Aminothiazol-4-yl)-2-(3-N-tert-butoxycarbonylaminopropoxyimino)acetate To a mixture of ethyl 2-amino-alpha-(hydroxyimino)-4-thiazoleacetate (139.9 g, 650 mmol), tert-butyl 3-bromopropylcarbamate (209.0 g, 877.5 mmol) and powdered potassium carbonate (157.2 g, 1137.5 mmol) was added DMF (550 mL) and water (24.4 mL). The resulting mixture was stirred at 30 C. for about 11 h. The reaction mixture was cooled to room temperature and ethyl acetate (2.3 L) and water (1.7 L) were added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. An aqueous sodium bicarbonate solution (10 wt. %, 600 mL) was added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. An aqueous sodium chloride solution (10 wt. %, 600 mL) was added and the resulting mixture was stirred for 5 min. The mixture was allowed to stand for 60 min and the lower layer (aqueous layer) was separated and discarded. The organic layer was concentrated to a volume of about 600 mL. Hexanes (250 mL) were added dropwise to the concentrate with gently stirring at 0 C. for 1 h to form a precipitate. The precipitate was collected by vacuum filtration to give the title compound (232 g, 96% yield) as an off-white crystalline solid. 1H NMR (400 MHz, DMSO-d6) delta 7.25 (s, 2H), 6.89 (s, 1H), 6.82 (brs, 1H), 4.26 (q, J=8 Hz, 2H), 4.08 (t, J=6.4 Hz, 2H), 2.97 (q, J=6.4 Hz, 2H), 1.72 (m, J=6.4 Hz, 2H), 1.37 (s, 9H), 1.26 (t, J=8 Hz, 3H).

64485-82-1 (Z)-Ethyl 2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetate 6738988, athiazole compound, is more and more widely used in various.

Reference£º
Patent; THERAVANCE, INC.; Zhang, Weijiang; Cheung, Ronnie; Filipov, Dimitar; Green, Jack; Lee, Junning; US2014/274877; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

13.4 g (84.7 mmol) 2-Amino-4-methyl-thiazole-5-carboxylic acid and 35.8 mL (279 mmol) propionic anhydride in 90 mL propionic acid are stirred at 10000 over night. The resulting mixture is cooled to r.t., 200 mL water are added and stirred for 30 mm. The precipitate is filtered off and treated with 200 mL water. After stirring for 30 mm the precipitate is filtered off, washed with water and dried at 50CC.C8H10N203S (M = 214.2 g/mol)ESI-MS: 215 [M-i-H] R (HPLC): 0.68 mm (method J)

67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; HAEBEL, Peter Wilhelm; HEIMANN, Annekatrin; HEINE, Niklas; (172 pag.)WO2016/41845; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.160844-75-7,Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate,as a common compound, the synthetic route is as follows.

Example-4 Preparation of Febuxostat Potassium (IA-b) 3.7 N potassium hydroxide solution was added to a reaction mass of (50.0 g) 2-(4-isobutoxy-3-cyanophenyl)-4-methylthiazole-5-ethyl carboxylate in (250.0 ml) isopropyl alcohol. The reaction mixture was stirred and heated to get complete potassium salt of febuxostat. The febuxostat potassium was isolated by filtration. The moisture content of the said compound is 6.03percent. HPLC purity: >99percent The XRPD of potassium salt of febuxostat is attached as .

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; CADILA HEALTHCARE LIMITED; Dwivedi, Shriprakash Dhar; Prasad, Ashok; Roy, Rushikesh Udaykumar; Patel, Mayur Ramnikbhai; US2013/190366; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica