Month: September 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51640-36-9,2-Chlorothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.

2-(6-Piperidin-1-yl-pyrimidin-4-ylamino)-thiazole-5-carbonitrile (22-10) A flame dried flask under Ar was charged with sodium hydride (35 mg, 60% dispersion, 0.86 mmol) and 2 mL anhydrous THF. 6-Piperidin-1-yl-pyrimidin-4-ylamine (70 mg, 0.39 mmol) was added slowly followed after 10 minutes by the addition of 2-chloro-thiazole-5-carbonitrile (68 mg, 0.47 mmol). After 1 hour at room temperature the reaction was heated to reflux. After 4 hours, the reaction was cooled, diluted with water and adjusted to pH 7 with 1M HCl (aq). The resulting precipitate was filtered washed with water and air dried. The resulting solid triturated with ether, sonucated, filtered and washed with ether. 1H-NMR (400 MHz, DMSO-6) 11.99 (s, 1H), 8.39 (1H,s), 8.24 (1H,s), 6.20 (1H,s), 3.57-3.54 (m, 4H), 1.64-1.53 (m, 6H). M+1=287.3. mp>250.

51640-36-9, The synthetic route of 51640-36-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Bilodeau, Mark T.; Hartman, George D.; Hoffman JR., Jacob M.; Sisko, John T.; Manley, Peter J.; Smith, Anthony M.; Tucker, Thomas J.; Lumma JR., William C.; Rodman, Leonard; US2002/137755; (2002); A1;,
Thiazole | C3H3NS – PubChem
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.161798-03-4,Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate,as a common compound, the synthetic route is as follows.

c) Preparation of Ethyl 2-(3-cvano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate [Compound of formula V]. 350.0gm of Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate, [Compound of formula IV] 123.0gm of sodium formate followed by 84.0gm of hydroxylamine hydrochloride were added to 1.4 ltr of formic acid. Reaction mixture was heated to reflux and stirred for 5hr to complete the reaction. Reaction solution was cooled to 25C. Slowly added 2.8 ltr of water at 25C. Slurry formed was stirred for about l.Ohr, filtered, washed with water and dried under vacuum to give 321.0gm of titled compound.Analytical Data- ¡¤ ^NMR (CDC13, 400 MHz) : delta 1.053-1.104 (doublet, 6H); delta 1.368-1.416 (triplet,3H); delta 2.164-2.253 (multiplet, 1H); delta 2.768 (singlet, 3H); delta 3.890-3.911 (doublet, 2H); delta 4.324-4.395 (quartet, 2H); delta 6.998-7.027 (doublet, 1H); delta 8.075-8.112 (doublet of doublet, 1H); delta 8.175-8.182 (doublet, 1H).? Mass (m/e) : 345.2, 161798-03-4

The synthetic route of 161798-03-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SANDOZ AG; LUTHRA, Parven, Kumar; KHAN, Rashid; SALUNKHE, Dadasaheb; NASIR ALI, Shafakat, Ali; WO2012/131590; (2012); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.41731-83-3,Ethyl 2-bromothiazole-5-carboxylate,as a common compound, the synthetic route is as follows.,41731-83-3

Step 1: ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate A mixture of bromo(pyridine-2-yl)zinc (0.5 M in THF, 1.27 mL), ethyl 2-bromo-1,3-thiazole-5-carboxylate (0.063 mL, 0.42 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.02 g, 0.02 mmol) in 1,4-dioxane (3 mL) and water (0.03 mL) was subjected to MWI at 120 C. for 10 min. The reaction mixture was diluted with water and extracted with EtOAc. The organic solutions were combined, dried over Na2SO4, filtered, and concentrated to give ethyl 2-pyridin-2-yl-1,3-thiazole-5-carboxylate (0.12 g) which was used without further purification. LCMS: (FA) ES+235.

As the paragraph descriping shows that 41731-83-3 is playing an increasingly important role.

Reference£º
Patent; Millennium Pharmaceuticals, Inc.; US2008/171754; (2008); A1;,
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1235406-42-4, tert-Butyl thiazol-4-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1. Preparation of thiazol-4-amine hydrochloride To a mixture of tert-butyl thiazol-4-ylcarbamate (34.0 g, 169.8 mmol) in dichloromethane (150 mL) was added 4.0 M hydrochloric acid in anhydrous dioxane (180 mL). The reaction mixture was stirred at ambient temperature for 3 hours and then filtered. The residue rinsed with diethyl ether (80 mL) to afford the title compound as a colorless solid (22.99 g, 99% yield): MS (ES+) m/z 101 (M+1).

1235406-42-4, 1235406-42-4 tert-Butyl thiazol-4-ylcarbamate 53241636, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Xenon Pharmaceuticals Inc.; Andrez, Jean-Christophe; Burford, Kristen Nicole; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Jia, Qi; Lofstrand, Verner Alexander; Wesolowski, Steven Sigmund; Wilson, Michael Scott; US2020/71313; (2020); A1;,
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1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1452-15-9, Preparation of Products; To a mixture of nitrile (60 mg) and substituted aniline (leq) was added AlCl3 (leq). The mixture was heated up to 2000C and stirred for 20 min under N2. The mixture was cooled and the product purified by preparative HPLC.

As the paragraph descriping shows that 1452-15-9 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME LIMITED; WO2007/138343; (2007); A1;,
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59020-44-9, 4-Phenylthiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,59020-44-9

The desired carboxylic acid (1.2-1.5 eq) is suspended in CH2Cl2, and treated with oxalyl chloride (6 eq) and DMF (catalytic) for 1.5 to 18 hours to obtain a clear solution. The solution was concentrated to dryness and a pyridine suspension of the desired aniline (1.0 eq) was added and the reaction mixture was stirred at room temperature for up to 18 hours or microwave heated (160 deg C, 10 min). If the product precipitates from solution it is collected by filtration, co-evaporated with methanol and purified by chromatography. If it does not precipitate from solution it can be concentrated to dryness, triturated and then purified by chromatography.Acid chlorides were also prepared by suspending the appropriate acid in SOCl2 and heating at reflux for several hours. The excess SOCl2 is removed under reduced pressure, and the residue chased with toluene. The resulting acid chloride was dried under vacuum and used without further pur. The title compound was prepared according to amide synthesis general method B, utilizing 2-(6-((4-(2-methoxyethyl)piperazin-l-yl)methyl)thiazolo[5,4- b]pyridin-2-yl)aniline and 4-phenylthiazole-2-carboxylic acid (1.5 eq). Addition of water to the crude reaction did not precipitate the product, therefore it was concentrated, triturated with hot MeCN, MeCN/EtOAc/MeOH mixture, and EtOAC/MeOH sequentially. The resulting pale yellow solid was lyophilized with a MeCN/water/HCl mixture and subsequently purified on prep HPLC. MS Calcd for C30H30N6O2S2: 570.19. Found (M+H)+ m/z = 571

As the paragraph descriping shows that 59020-44-9 is playing an increasingly important role.

Reference£º
Patent; SIRTRIS PHARMACEUTICALS, INC.; OALMANN, Christopher; DISCH, Jeremy, S.; NG, Pui, Yee; PERNI, Robert, B.; WO2010/71853; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.101258-16-6,1-(2-Aminothiazol-4-yl)ethanone,as a common compound, the synthetic route is as follows.

To a DMF (5 mL) solution of (trans)- 3-((3-bromobenzofuran-7- yl)oxy)cyclobutanecarboxylic acid (Intermediate 1 12) (100 mg, 0.321 mmol) was added HATU (147 mg, 0.386 mmol) and N,N-diisopropylethylamine (0.17 mL, 0.96 mmol). After 5 minutes, 1 -(2-aminothiazol-4-yl)ethanone (50 mg, 0.35 mmol) was added, and the mixture was stirred for 12 h, poured into water, and extracted with EtOAc (3X). The combined organic layers were dried over Na2SC>4, filtered and concentrated. This residue was purified on silica gel, eluting with 0%-100% EtOAc: EtOH (3:1 ) in hexanes to give the title compound (97 mg, 58%). 1H NMR (400 MHz, CD3SOCD3) delta 2.37-2.44 (m, 2 H), 2.66 (s, 3 H), 2.67-2.75 (m, 2 H), 3.42 (d, J = 5 Hz, 1 H), 5.03 (t, J = 6 Hz, 1 H), 6.72 (d, J = 8.40 Hz, 1 H), 6.82-6.94 (m, 1 H), 7.32-7.41 (m, 1 H), 8.03-8.15 (m, 2 H), 12.50 (s, 1 H); LC-MS (LC-ES) M+H = 435, 437 (Br pattern)., 101258-16-6

As the paragraph descriping shows that 101258-16-6 is playing an increasingly important role.

Reference£º
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DEATON, David Norman; GUO, Yu; HANCOCK, Ashley Paul; SCHULTE, Christie; SHEARER, Barry George; SMITH, Emilie Despagnet; STEWART, Eugene L.; THOMSON, Stephen Andrew; (556 pag.)WO2018/69863; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1603-91-4,4-Methylthiazol-2-amine,as a common compound, the synthetic route is as follows.

To a round bottom flask containing 40 mL CHUCK was added I (695 mg, 6.09 mmol), 4-DMAP (52.3 MG, 0.43 mmol), and BOC20 (1.374 g, 6.29 mmol). The reaction mixture was stirred overnight at room temperature. Concentration of the solution in vacuo was followed by purification by column chromatography (silica gel, hexanes: EtOAc, 10: 1), affording the product as white crystals (54 %)., 1603-91-4

As the paragraph descriping shows that 1603-91-4 is playing an increasingly important role.

Reference£º
Patent; NORTHWESTERN UNIVERSITY; WO2005/26111; (2005); A2;,
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5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,5398-36-7

To a solution of ethyl 2-aminothiazole-4-carboxylate (100 g, 581 mmol) and copper (II) bromide (195 g,871 mmol) in acetonitrile (1000 ml) at 0 C, tert-butylnitrite (104 ml, 871 mmol) was added dropwise. The reaction mixture was warmed to room temperature and stirred for 12h. After completion of thereaction, the reaction mixture was diluted with a mixture of ethyl acetate (1000 ml) and water (3000 ml) and then acidified to pH 2 using iN hydrochloric acid. The two layers were separated and the aqueous layer was again extracted three times with ethyl acetate (500 ml). The combined organic layers were dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by recrystallization from hexane to obtain pure ethyl 2-bromo-1,3-thiazole-4-carboxylate (115 g,84% yield).?H-NMR (400 MHz, DMSO-d6) 8.52 (s, IH), 4.29 (q, J 7.1 Hz, 2H), 1.29 (t,J 7.1 Hz, 3H)MS: m/z235.90. [M+1].

As the paragraph descriping shows that 5398-36-7 is playing an increasingly important role.

Reference£º
Patent; PI INDUSTRIES LTD.; SHANBHAG, Gajanan; DODDA, Ranga Prasad; KAMBLE, Ganesh Tatya; KALE, Yuvraj Navanath; RENUGADEVI, G.; MANJUNATHA, Sulur G; S.P., Mohan Kumar; AUTKAR, Santosh Shridhar; GARG, Ruchi; VENKATESHA, Hagalavadi M; MAVINAHALLI, Jagadeesh Nanjegowda; KLAUSENER, Alexander G.M.; (161 pag.)WO2018/193387; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53332-78-8,Thiazol-2-ylmethanamine dihydrochloride,as a common compound, the synthetic route is as follows.

53332-78-8, A mixture of 5-bromo-3-(pyrrolidin-l-ylsulfonyl)-lH-indole-2-carboxylic acid (37 mg,0.1 mmol), PS-DCC (170 mg, 0.20 mmol) and EtaOBt (14 mg, 0.1 mmol), (l,3-thiazol-2-ylmethyl)amine (dihydrochloride salt, 39 mg, 0.2 mmol), and DIEA (100 uL) in TEtaF/DCM (1:1, 2 mL) was shaken for 16 hours at room temperature. After this time, the resin was filtered and washed with DCM/MeOEta (1:1, 4 x 1.5 mL). The combined organic solution was concentrated and the residue was purified by LCMS to give the title product (TFA salt) as slightly yellow solidAnalytical LCMS: single peak (214 nm), 3.254 min, ES MS (M+l) = 469; lEta NuMR (500 MHz, d6-DMSO) delta 13.02 (br, IH), 9.61 (t, J= 6.1 Hz, IH),8.12 (d, J= 1.8 Hz, IH), 7.77 (d, J= 3.2 Hz, IH), 7.70 (d, J= 3.2 Hz, IH), 7.53 (d, J= 8.7 Hz, IH), 7.48 (dd, J= 8.7, 1.8 Hz, IH), 4.88 (d, J= 6.1 Hz, IH ), 3.16-3.12 (m, 4H), 1.67-1.63 (m, 4H); HRMS, calc’d for Ci7HisBrNu4theta3S2 (M+H), 468.9998; found 469.0015.

53332-78-8 Thiazol-2-ylmethanamine dihydrochloride 44890709, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MERCK & CO., INC.; WO2007/2368; (2007); A2;,
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Thiazole | chemical compound | Britannica