Day: September 1, 2020

5198-88-9,5198-88-9, 2-Bromothiazole-4-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5Preparation of Compound 5To a solution of 2-bromo-thiazole-5-carboxylic acid (0.050 mmol, 10 mg), lambda/,lambda/-diisopropylethylamine (0.20 mmol, 26 mg) and HATU (0.050 mmol, 19 mg) in DMF (1 ml_) was added 4-(2-aminophenyl)-piperazine-1-carboxylic acid tert-butyl ester (0.10 mmol, 28 mg). The resulting reaction was heated to 80 0C and allowed to stir at this temperature for 15 hours, after which time the reaction mixture was cooled to room temperature and concentrated in vacuo. The resulting residue was reacted with TFA (0.5 ml_) for 10 minutes. The TFA solution was then concentrated in vacuo Xo provide a crude residue which was purified using reverse phase HPLC to provide Compound 5.

The synthetic route of 5198-88-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; WO2008/54702; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example-2 Preparation of Ethyl-2-(3-cyano-4-hydroxyphenyl)-4-methyl thiozole-5-carboxylate A mixture of 10.0 g of Ethyl-2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 30 g of Dimethylformamide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 90¡ã C. for 2-3 hours. Reaction mass was cooled to room temperature and diluted with 100 ml of water and stir for 2 hours. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-hydroxy phenyl)-4-methyl thiozole-5-carboxylate (yield 99.0percent)., 161798-01-2

161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Vellanki, Siva Rama Prasad; Sahu, Arabinda; Raavi, Satyanarayana; Nuchu, Ravi; Dandala, Ramesh; US2013/303780; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A solution containing 300 mg of 16h, 180 mul of 5-Br-thiazole, 350 mul of diisopropyl amine, 21mg of PdCl2(benzonitrile)2, 250 mul of IM tri-te/t-butyl phosphine (in toluene), 12 mg of CuI in 2 ml of degassed dioxane was stirred overnight at RT under a N2 atmosphere. The mixture was poured onto 5% aq. NH4CI and extracted with ethyl acetate. The extract was dried, concentrated and the crude material was purified by chromatography over silica gel, using a gradient of heptane/ethyl acetate as eluent. This afforded 320 mg 16i as a colorless oil. Rf 0.45 (heptane/ethyl acetate 1/1). MS-ESI: [M+l] 337.17NMR (CDCl3) delta 8.64 and 7.88 (2x s, 2, thiazole H), 1.40 (m, 2, CH2), 1.48 (s, 9, tertC49), 1.64 (m, 4, 2x CH2), 2.46 (t, 2, CH2), 3.20 (m, 2, CH2), 3.83 (s, 3, OCH3).

3034-55-7, As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Patent; N.V. ORGANON; LOOZEN, Hubert, Jan, Jozef; TIMMERS, Cornelis, Marius; STOCK, Herman, Thijs; WO2011/12600; (2011); A1;,
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Thiazole | chemical compound | Britannica

160844-75-7, Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 5:Preparation of febuxostat2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester (100 gm) was dissolved in ethanol (500 ml) at room temperature and then added a solution of sodium hydroxide (13 gm) in water. (250 ml) slowly for 30 minutes. The contents were heated to 65C and maintained for 1 hour. The reaction mass was then cooled to 50C and pH of the reaction mass was adjusted to 2.0 with hydrochloric acid solution (15%). The reaction mass was stirred for 15 minutes at 50C and then cooled to room temperature. The contents were maintained for 3 hours at room temperature and filtered. The solid thus obtained was dissolved in ethanol (500 ml) and then heated to 60C. The reaction mass was treated with carbon at 60C and filtered. The filtrate obtained was then cooled to room temperature and stirred for 2 hours. The reaction mass was further cooled to 10C and maintained for 1 hour. The solid obtained was collected by filtration and washed with chilled ethanol to obtain a wet solid. To the wet solid was added a mixture of ethanol and water (9: 1 ; 500 ml) at room temperature and then heated to 60C to obtain a solution. The solution was stirred for 30 minutes at 60C and then cooled to 25C. The reaction mass was maintained for 1 hour at 25C and the mass was further cooled to 10C. The solid obtained was collected by filtration and dried with vacuum sucking for 15 minutes to obtain 65 gm of febuxostat., 160844-75-7

160844-75-7 Ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate 9884549, athiazole compound, is more and more widely used in various.

Reference£º
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAMAKRISHNA REDDY, Matta; VAMSI KRISHNA, Bandi; WO2012/168948; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

21344-90-1, 4-(2-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

276A N-[4-(2-chlorophenyl)-1,3-thiazol-2-yl]-4-propylbenzenesulfonamide The title compound was prepared from 4-(2-chlorophenyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (30.9 mg) with purity >90percent. MS (pos) m/z 393.1.

21344-90-1, As the paragraph descriping shows that 21344-90-1 is playing an increasingly important role.

Reference£º
Patent; Kurz, Guido; Nilsson, Marianne; US2003/166689; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.67899-00-7,2-Amino-4-methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The suspension of acid (2.00 mmol) in DMF (10 mL) was cooled to 0 C in an ice bath. N-methylmorpholine (0.49 mL, 4.40 mmol) and TBTU (0.84 g, 2.60 mmol) were added, and the reaction mixture was stirred at 0 C for 0.5 h. Then it was allowed to reach room temperature, and amine (2.00 mmol) was added to the solution.The reaction mixture was stirred overnight at room temperature, after which the solvent was evaporated under reduced pressure.The residue was dissolved in ethyl acetate (40 mL) and washed witha saturated aqueous solution of NaHCO3 (3 x 20 mL), 10% citric acid(3 x 20 mL) and brine (20 mL). The organic phase was dried over Na2SO4, and filtered, and the solvent was removed under reduced pressure. The crude product was purified by crystallization or flash column chromatography., 67899-00-7

67899-00-7 2-Amino-4-methylthiazole-5-carboxylic acid 832243, athiazole compound, is more and more widely used in various.

Reference£º
Article; ?kedelj, Veronika; Perdih, Andrej; Brvar, Matja?; Krofli?, Ana; Dubbee, Vincent; Savage, Victoria; O’Neill, Alex J.; Solmajer, Tom; Be?ter-Roga?, Marija; Blanot, Didier; Hugonnet, Jean-Emmanuel; Magnet, Sophie; Arthur, Michel; Mainardi, Jean-Luc; Stojan, Jure; Zega, Anamarija; European Journal of Medicinal Chemistry; vol. 67; (2013); p. 208 – 220;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34272-64-5,2-(4-Methyl-2-thioxo-2,3-dihydrothiazol-5-yl)acetic acid,as a common compound, the synthetic route is as follows.

EXAMPLE 172 7-beta-Amino-3-(5-carboxymethyl-4-methyl-1,3-thiazol-2-yl-thiomethyl)-ceph-3-em-4-carboxylic acid 2.7 g (0.01 mole) of 7-aminocephalosporanic acid and 1.9 g (0.01 mole) of 5-carboxymethyl-2-mercapto-4-methyl-1,3-thiazole are suspended in 250 ml of water. Sodium bicarbonate is added until a clear solution has formed. The reaction solution is heated to 50 C. for 4 hours, whilst keeping the pH value constant at the neutral point. The solution is allowed to cool and is extracted several times with ethyl acetate and the aqueous phase is adjusted to a pH value of 2 with 2 N HCl. The precipitate is filtered off, washed several times with alcohol and ether and dried. 3.7 g of the title compound of melting point 195-196 C. (decomposition) are obtained. NMR (d6 -DMSO, 60 MHz): delta=2.17 ppm (s, 3H, =C–CH3), delta=3.52 ppm (AB, 2H, 2–CH2 –), delta=3.68 ppm (s, 2H, =C–CH2 –COO–) delta=4.31 ppm (AB, 2H, 3–CH2 –S–) and delta=4.80 ppm (m, 2H, 6–CH–+7–CH–)., 34272-64-5

As the paragraph descriping shows that 34272-64-5 is playing an increasingly important role.

Reference£º
Patent; Hoechst Aktiengesellschaft; US4278793; (1981); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5198-88-9,2-Bromothiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.,5198-88-9

a) Preparation of Intermediate V.1 N-[2-(Aminocarbonyl)phenyl]-2-bromo-4-thiazolecarboxamide (Intermediate V.1) 2-Bromo-4-thiazolecarboxylic acid (1 g), HATU (2.01 g) and 2-aminobenz-amide (0.65 g) are introduced into N,N-dimethylformamide (DMF) (20 ml). The mixture is cooled with an ice bath, and N,N-diisopropylethylamine (0.90 ml) is added. The reaction mixture is stirred at room temperature for 6 days, poured into ice-water and allowed to thaw with stirring, and the precipitated solid is filtered off with suction, washed twice with water, twice with diethyl ether and dried in vacuo. Intermediate V.1 is obtained as a solid (1.4 g). C11H8BrN3O2S, M=326.2. 1H-NMR (300 MHz, D6-DMSO): delta=7.20 (m, 1H), 7.56 (m, 1H), 7.79 (s, 1H), 7.84 (m, 1H), 8.30 (s, 1H), 8.47 (m, 1H), 8.67 (m, 1H), 12.9 (s, 1H).

As the paragraph descriping shows that 5198-88-9 is playing an increasingly important role.

Reference£º
Patent; Ulrich, BOTHE; Arne, Von Bonin; Duy, Nguyen; Ulf, Bomer; Judith, Guenther; US2009/163486; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80945-83-1,2-Chlorobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

80945-83-1, Step 1 : 2-(4-(2-chloro-4-((5-cvclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)-4- hvdroxypiperidin-1-yl)benzo[d]thiazole-6-carbonitrile To a sealed tube equipped with a magnetic stirring bar, 4-(2-chloro-4-((5-cyclopropyl-3-(2,6- dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)piperidin-4-ol hydrochloride (General synthesis 4, step 2) (100 mg, 0.19 mmol), 2-chlorobenzo[d]thiazole-6-carbonitrile (54.1 mg, 0.23 mmol), potassium carbonate (234 mg, 3.8 mmol) and DMF ( 2 mL) were added. The tube was sealed and the mixture was heated at 80 ¡ãC for 40 minutes. Water (20 mL) was added and the resulting mixture was extracted with EtOAc (50 mL X 3), the combined organic phases were washed with brine (20 mL), dried over Na2S04, filtered, and concentrated in vacuo. Silica gel column chromatography gave the desired product (37 mg, 30percent yield).

The synthetic route of 80945-83-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GILEAD SCIENCES, INC.; KINZEL, Olaf; KREMOSER, Claus; BLOMGREN, Peter, A.; CURRIE, Kevin, S.; KROPF, Jeffrey, E.; SCHMITT, Aaron; WATKINS, William, J.; XU, Jianjun; GEGE, Christian; (92 pag.)WO2016/96116; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1452-15-9, 4-Cyanothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The mixture was heated to distill off 130 ml of 1-butanol+water. When the pot temperature reached about 70 C., all of the o-phenylenediamine monohydrochloride salt was in solution. When half (~65 ml) of the 1-butanol+water has been distilled, 55 g (0.5 mole) of 4-cyanothiazole were added to the reaction flask and a water scrubber (200 ml of water) was added to the exit of the condenser. After a total of 130 ml of 1-butanol+water was distilled, which took about 40 minutes, the Dean-Stark trap was removed from the system. During the removal of 1-butanol+water, the temperature of the reaction mixture rose to 115 C. As the reaction progressed the reflux temperature gradually decreased to 110 C. from an initial reflux temperature of 115 C. Thiabendazole formed during refluxing as a precipitate., 1452-15-9

1452-15-9 4-Cyanothiazole 15069, athiazole compound, is more and more widely used in various.

Reference£º
Patent; E. I. Du Pont de Nemours and Company; US5310923; (1994); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica