29927-08-0, 5,6-Dimethylbenzo[d]thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: 2-Aminobenzothiazole (0.30 g, 2.0 mmol) was dissolved in hot glacial acetic acid/propionic acid mixture (2:1, 6.0 ml) and was rapidly cooled in an ice-salt bath to -5 C. The mixture was then stirred for 2 h. at 0-5 C. The liquor was then added in portions during 30 min to a cold solution of nitrosyl sulfuric acid [prepared from sodium nitrite (0.15 g) and concentrated sulfuric acid (3 ml at 50 C)]. The mixture was stirred for an additional 2 h at 0 C. Excess nitrous acid was destroyed by the addition of urea. The resulting diazonium salt was cooled in salt/ice mixture. 2-methlyindole(0.26 g, 2.0 mmol) was dissolved in mixture of acetic acid/propionic acid solution (3:1, 8.0 ml) and cooled in salt/ice bath and then cold diazonium solution was added to this cooled solution by stirring in a dropwise manner. The solution was stirred at 0-5 C for 2 h. and pH of the reaction mixture was maintained at 4-6 by simultaneous addition of saturated sodium carbonate solution.The mixture was stirred for a further 1 h at 5 C. The resulting product was filtered, washed with water, dried and crystallized from ethanol mixture gave brown powder (yield: 0.29 g, 51%; m.p: 168-170 C), FT-IR (KBr) numax: 3345 (indole -NH), 3059 (aromatic C-H), 2969, 2920 (aliphatic C-H), 1605 (C=C) cm-1; 1HNMR (DMSO-d6/CDCl3): d 9.71 (b, indole -NH), 7.98 (1H,m), 7.37(1H,m), 7.30-7.15 (4H,m), 6.82 (2H,m), 2.36 (3H,s).Anal. Calcd. For C16H12N4S: C, 65.73; H, 4.14; N, 19.16; S, 10.97Found: C, 65.68; H, 4.19; N, 19.11; S, 10.92%.MS (m/z, 70 eV): 292.0 (M+), 277.0, 158.0, 130.0.
29927-08-0, Big data shows that 29927-08-0 is playing an increasingly important role.
Reference£º
Article; Sefero?lu, Zeynel; Kaynak, Filiz Betul; Ertan, Nermin; Ozbey, Suheyla; Journal of Molecular Structure; vol. 1047; (2013); p. 22 – 30;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica