With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19654-14-9,2-(3-Bromophenyl)benzothiazole,as a common compound, the synthetic route is as follows.
Intermediate 6 (10.4 g, 35.8 mmol), intermediate 7 (9.20 g, 39.3 mmol), a mixed solution of toluene / ethanol (2: 1, 195 mL), aqueous tripotassium phosphate (2.0 M, ) Were sequentially added, and nitrogen bubbling was carried out for 30 minutes.Pd (PPh 3) 4 (1.00 g, 0.87 mmol) was added thereto, and the mixture was stirred for 3 hours while heating under reflux. After returning to room temperature, distilled water was added and extraction was carried out using toluene.The organic layer was washed with a saturated aqueous sodium chloride solution, dried over magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was subjected to silica gel column chromatography to give Intermediate 8 (13.6 g, yield 95%). Intermediate 6 was synthesized by referring to the method described in International Publication No. 2015/087961., 19654-14-9
As the paragraph descriping shows that 19654-14-9 is playing an increasingly important role.
Reference£º
Patent; MITSUBISHI CHEMICAL CORPORATION; KOMATSU, HIDEJI; ISHIBASHI, KOICHI; NAGAYAMA, KAZUHIRO; (41 pag.)JP2018/58797; (2018); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica