With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.556-90-1,2-aminothiazol-4(5H)-one,as a common compound, the synthetic route is as follows.,556-90-1
General procedure: Synthesis of Compounds 120 to 122, which are (Z)-5-(substituted benzylidene)-2-iminothiazolidin-4-one analogs, was performed as follows. In detail, in an acetic acid (4 mL/1 g sodium acetate) solvent, a mixture including a substituted benzaldhehyde (300 mg), pseudothiohydantoin (1.1 eq.), and sodium acetate (3.0 eq.) was refluxed for 3 to 7 hours. After cooling, water was added thereto, and the produced precipitate was filtered, and in consideration of physical characteristics of the used starting materials, the resultant precipitate was washed with water and methylene chloride and/or ethyl acetate to obtain a solid target product.
556-90-1 2-aminothiazol-4(5H)-one 11175, athiazole compound, is more and more widely used in various.
Reference£º
Patent; Pusan National University Industry University Cooperation Foundation; Jung, Hae Young; Moon, Hyung Ryong; Park, Min Hwe; Ha, Young Mi; Park, Yoon Jung; Park, Ji Young; Kim, Jin-a; Lee, Ji Yeon; Lee, Kyung Jin; (57 pag.)KR101677122; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica