With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2942-23-6,2,7-Dichlorobenzo[d]thiazole,as a common compound, the synthetic route is as follows.
In a nitrogen atmosphere 2,7-dichlorobenzo[d]thiazole (10.0 g, 49.3mmol) and (9-phenyl-9H-carbazol-3-yl)boronic acid(28.3 g, 98.6 mmol) was added to 300 ml of dioxane, stirred and refluxed. Then potassium carbonate (27.2 g, 197.1 mmol)Was dissolved in 50 ml of water and stirred sufficiently, followed by bis(tri-tertiary-butylphosphine)palladium (1.0 g, 4 mol%) Was added. After the reaction for 12 hours, the temperature was reduced to room temperature, the organic layer and the water layer were separated, and then the organic layer was distilled under reduced pressure.After distillate was extracted with chloroform and water, the organic layer was dried using magnesium sulfate. After drying the organic layer, compound 1 (13.4 g, 44%) was prepared through recrystallization of ethyl acetate., 2942-23-6
The synthetic route of 2942-23-6 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Jang Bun-jae; Lee Jeong-ha; Han Su-jin; Park Seul-chan; Hwang Seong-hyeon; (37 pag.)KR2020/6503; (2020); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica