Day: September 4, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.185613-91-6,4-(Benzo[d][1,3]dioxol-5-yl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

4-(Benzo[d] [1,3]dioxol-5-yl)thiazol-2-amine(2) (1.00 g, 4.54 mmol) and NaH (0.164 g, 6.82 mmol) to THF (15 ml) todissolved and then allowed to react at room temperature for 1 hour under a nitrogen stream. Then slowly added dropwise atroom temperature 3a(trifluoromethyl) benzyl bromide (1.63 g, 6.82 mmol) and allowed to react for 10 minutes. After thereaction was finished, it was concentrated under reduced pressure and extracted three times into a saturated solution ofNaHCO3 is dissolved in ethyl acetate. The ethyl acetate layer was separated and dried with anhydrous Na2SO4, then purifiedby column chromatography (Ethyl acetate: Hexane = 1: 5) to give the compound 1c to give. Yield 17.2%

185613-91-6, The synthetic route of 185613-91-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chungbuk National University Industry-Academic Cooperation Foundation; Jung, Jae Kyung; Kim, Young Soo; Lee, Hee Sun; (27 pag.)KR101651208; (2016); B1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.143577-46-2,(R)-Tetrahydro-3H-pyrrolo[1,2-c][1,2,3]oxathiazole 1,1-dioxide,as a common compound, the synthetic route is as follows.

To a solution of anhydrous THF (100 ml) containing compound 87 (3.42 g, 9.69 mmol) was added 3.9 ml n-Buli (2.5 M in hexane) dropwise (-78 C. under N2). After the addition, the resulting solution was stirred for 60 minutes at -78 C. At this temperature, a solution of 35 (1.58 g, 9.69 mmol) in 10 ml THF was added dropwise (5 minutes). After the addition of 35, the temperature was raised to -20 C. and the resulting solution was stirred for 2 hours. The mixture was allowed to warm to ambient temperature and stirred for another 2 hours.The reaction mixture was concentrated and the residue was dissolved in 40 ml 1N HCl, 40 ml EtOH and 40 ml THF. The mixture was stirred at 80 C. for 18 hours. The reaction mixture was concentrated in vacuo. MeOH (25 ml) was added and the mixture was concentrated on 25 g SiO2, Subsequent flash chromatography (MeOH/triethylamine (98/2) afforded the title compound: (R)-3-Pyrrolidin-2-ylmethyl-1H-pyrrolo[3,2-b]pyridine.(compound 88), (amorphous, 0.32 g, 0.72 mmol, 9.3%). 1H-NMR (400 MHz, CDCl3): delta 9.1 (bs, 1H), 8.42 (dd, J=5 Hz, 2 Hz, 1H), 7.58 (dd, J=8 Hz, 2 Hz, 1H), 7.20 (s, 1H), 7.06 (dd, J=8 Hz, 5 Hz, 1H), 3.59-3.51 (m, 1H), 3.14-3.02 (m, 2H), 2.97-2.85 (m, 2H), 2.0-1.90 (m, 1H), 1.86-1.71 (m, 2H), 1.54-1.43 (m, 1H). LCMS: Rt; 0.64 min, ([M+H]+=202). [alpha]D25-10 (c 1, dioxane).

143577-46-2, The synthetic route of 143577-46-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; STOIT, Axel; Coolen, Hein K.A.C.; Van Der Neut, Martina A. W.; Kruse, Cornelis G.; US2008/9514; (2008); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55661-33-1,Thiazol-2-ylmethanamine,as a common compound, the synthetic route is as follows.,55661-33-1

Preparation of 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide; 1-(3,5-Di-tert-butyl-4-hydroxybenzamido)cyclopropanecarboxylic acid (100 mg, 0.3 mmol), thiazol-2-ylmethanamine (50 mg, 0.45 mmol), HATU (171 mg, 0.45 mmol) and DIPEA (0.15 mL, 0.9 mmol) were stirred in DCM at rt for 16 h. The organics were washed sequentially with saturated NaHCO3, 0.1 M HCl, dried (Na2SO4), concentrated in-vacuo and the residue purified by Biotage (5% MeOH/DCM) to give 3,5-di-tert-butyl-4-hydroxy-N-(1-(thiazol-2-ylmethylcarbamoyl)cyclopropyl)-benzamide (57 mg, 45.0%). MS: m/z=430.2 (calc’d for C23H31N3O3S 429.2).

As the paragraph descriping shows that 55661-33-1 is playing an increasingly important role.

Reference£º
Patent; Galemmo, JR., Robert; Holland, Richard; Hum, Gabriel; Pajouhesh, Hossein; Chahal, Navjot; Seid-Bagherzadeh, Mehran; Girard, Amy; US2009/270394; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.19759-66-1,2-Aminobenzothiazole-6-carbonitrile,as a common compound, the synthetic route is as follows.

19759-66-1, General procedure: A mixture of intermediate 4 (10 mmol), potassium carbonate (12 mmol) and various 2-aminobenzothiazoles (10 mmol) in acetone solvent (30 mL) was refluxed for 8 h. The progress of the reaction was monitored by TLC. After cooling to room temperature, the reaction mixture was treated with 200 mL cold water, and the resulting precipitate was filtered off. The crude products 5a-j were recrystallized from DMF.

As the paragraph descriping shows that 19759-66-1 is playing an increasingly important role.

Reference£º
Article; Patel, Amit B.; Raval, Rinku M.; Research on Chemical Intermediates; vol. 42; 3; (2016); p. 2163 – 2175;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

924287-65-0, Methyl 2-bromo-4-fluorobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,924287-65-0

To a 100 mL round-bottom flask purged with nitrogen was added (lR,3R,5S)-8- azabicyclo[3.2.1]octan-3-yl 5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazole-4- carboxylate 14e (360 nig, 0,85 mmol, 1.0 equiv.), DMSO (10 mL), methyl 2-bromo-4-fluoro- l,3-benzothiazole-6-carboxylate Al (294 mg, 1.01 mmol, 1.2 equiv.), and CsF (389 mg, 3.0 equiv.). The resulting mixture was stirred overnight at 115 C and then ethyl acetate was added (100 mL). The resulting mixture was washed with brine (20 mL x 2), dried over anhydrous sodium sulfate, filtered, and concentrated in vacuo. The resulting residue was purified via silica gel chromatography eluting with ethyl acetate/petroleum ether (1 :2) to afford methyl 2- [(lR,3R,5S)-3-([5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-l,2-oxazol-4-yl]carbonyloxy)-8- azabicyclo[3.2.1]octan-8-yl]-4-fluoro-l ,3-benzothiazole-6-carboxylate 14f (440 mg, 82%) as a light yellow solid.

The synthetic route of 924287-65-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (249 pag.)WO2018/39384; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29947-24-8,2-Bromo-4,5-dimethylthiazole,as a common compound, the synthetic route is as follows.

29947-24-8, To a microwave tube equipped with a stifling bar, (R)-4-((R)-1-((1-cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazol-7-yl)oxy)ethyl)pyrrolidin-2-one (120 mg, 0.292 mmol), 2-bromo-4,5-dimethylthiazole (112.1 mg, 0.584 mmol), 1,2-dimethoxyethane (2 mL), 1 N Na2CO3 aqueous solution (0.73 mL, 0.73 mmol) were added, the mixture was bubbled N2 for 5 minutes before Pd(PPh3)4 (14.0 mg, 0.012 mmol) were added. The tube was sealed and heated in an oil bath at 100 C. for 2 hrs. DCM (200 mL) was added and the resulting mixture was washed with saturated NaHCO3 aqueous solution (20 mL¡Á4), brine (20 mL¡Á1), dried over anhydrous Na2SO4, filtered, removed solvents in vacuo. The resulting residue was passed a ISCO silica gel column (MeOH:DCM=5:95) to give off-white solids, 56.0 mg (yield 48.4%).

29947-24-8 2-Bromo-4,5-dimethylthiazole 9942366, athiazole compound, is more and more widely used in various.

Reference£º
Patent; Gilead Scientific Systems, Inc.; Cory, Kevin S; Doo, Jimin; Farrand, Julie; Guerrero, Juan A; Katana, Ashley A; Cato, Daryl; Laisaweed, Scott I; Lee, Jiayao; Lingco, John O; Nicolaus, May; Notte, Gregory; Phyen, Hyeoung-Jung; Sangy, Michael; Sumit, Arun C; Adam J, Surayyah; Stephens, Cork L; Venkatraman, Chandrasekar; Watkins, William J; Yang, Jong Yu; Jabloki, Jeff; Jifel, Shiela; Ro, Jennifer; Lee, Sung H; Jao, Chung Dong; Grove, Jeffery; Su, Jianjun; Blomgren, Peter; Mitchell, Scott A; Shyung, Jin Ming; Chandrasekar, Jayaraman; (460 pag.)KR2016/37198; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

57268-16-3,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.57268-16-3,5-Bromo-2-methylthiazole,as a common compound, the synthetic route is as follows.

STEP 3 : To a solution of 4- {5-[(4-fluorophenyl)methyl]-6-methylpyrimidin- 4-yl}-7-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (46 mg, 0.096 mmol) and 5-bromo-2-methyl-l,3-thiazole (17 mg, 0.096 mmol) in dioxane (5 rnL) was added potassium carbonate (66 mg, 0.48 mmol) and [1,1 ‘- bis(diphenylphosphino)ferrocene]dichloropalladium (II) dichloromethane adduct (8 mg, 0.0096 mmol). The reaction mixture was stirred at 100 0C for 20 h, and then cooled to room temperature. The reaction mixture was concentrated, and then partitioned between ethyl acetate (100 mL) and water (50 mL). The layers were separated and the organic layer was washed with brine, dried over magnesium sulfate then filtered and concentrated. The residue was taken up in a minimum of acetonitrile and purified by preparative reverse phase HPLC to afford 4-{5-[(4-fluorophenyl)methyl]-6- methylpyrimidin-4-yl}-7-(2-methyl-l,3-thiazol-5-yl)-2,3,4,5-tetrahydro-l,4- benzoxazepine (18 mg) as a white powder. 1H NMR (400 MHz, DMSO-D6): 8.47 (s, IH), 7.77 (s, IH), 7.41 (dd, IH), 7.19-7.05 (m, 4H), 6.96 (d, IH), 6.83 (d, IH), 4.47 (s, 2H), 4.27 (t, 2H), 3.93 (s, 2H), 3.74 (t, 2H), 2.67 (s, 3H), 2.14 (s, 3H); MS (EI) for C25H23FN4OS: 446 (M+).

As the paragraph descriping shows that 57268-16-3 is playing an increasingly important role.

Reference£º
Patent; EXELIXIS, INC.; ANAND, Neel, Kumar; BAIK, Tae-Gon; BLAZEY, Charles, M.; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen; JOSHI, Anagha; KIM, Angie, Inyoung; MANALO, Jean-Claire, Limun; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WO2010/135568; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

10200-59-6, 2-Thiazolecarboxaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

N-Boc-piperazine (1.42 g, 7.6 mmol, 1.1 eq) was dissolved in 1,2-DCE (20 mL). To this solution, 2-thiazolecarboxaldehyde (0.780 g, 6.91 mmol, 1 eq) in 1,2-DCE (4 mL) was added followed by the portionwise addition of sodium triacetoxyborohydride (2.05 g, 9.68 mmol, 1.4 eq). The mixture was stirred at room temperature for 3 h and then washed with an aqueous saturated solution of NaHCO3. The organic layer was dried (MgSO4), the solvent removed in vacuo and the crude product was purified by column chromatography on a Biotage SP1 system (hexanes/EtOAc; v/v 6:4) to give the title compound (1.95 g, 100percent); 1H-NMR (500 MHz, CDCl3): delta 1.47 (s, 9H, C(CH3)3), 2.54 (t, 4H, J=4.7 Hz, piperazine N(CH2)2), 3.48 (t, 4H, J=5.0 Hz, piperazine N(CH2)2), 3.89 (s, 2H, NCH2), 7.30 (d, J=3.5 Hz, 1H, thiazole 5-H), 7.72 (d, J=3.5 Hz, 1H, thiazole 4-H); LC (Method B)-MS (ESI, m/z): Rt=2.84 min-306 [(M+Na)+, 100percent].

10200-59-6, 10200-59-6 2-Thiazolecarboxaldehyde 2734903, athiazole compound, is more and more widely used in various.

Reference£º
Patent; THE INSTITUTE OF CANCER RESEARCH; US2009/247507; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

79836-78-5,79836-78-5, Ethyl 2-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a 0¡ã C. solution of ethyl 2-methyl-thiazole-5-carboxylate (15 g, 88 mmol) in tetrahydrofuran (50 mL) was added aqueous sodium hydroxide solution (5 N, 50 mL) over 10 minutes, and the resulting solution was stirred at room temperature for another 2 hours. It was then acidified with hydrochloric acid (2 N) to pH=1 and extracted with tetrahydrofuran (3¡Á100 mL). The combined organic layers were washed with brine (30 mL) and dried over sodium sulfate. Most of the solvents were removed under reduced pressure and the residue was lyophilized to afford Compound (E) (14 g).

The synthetic route of 79836-78-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; CHUNG, John Inn; PIRJANIAN, Armen; ALVAREZ-NUNEZ, Fernando Antonio; KATZ, Jeffrey Michael; DAURIO, Dominick Paul; LA, Stevedat; KENNEDY, Michael T.; (52 pag.)US2018/161279; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

88982-82-5, 4-Bromo-1,3-thiazole-2-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,88982-82-5

Intermediate 14 (1.98g, 9.5 mmol) was dissolved in methanol (50 ml) and N-(3- dimethylaminopropyl)-iV-ethylcarbodiimide hydrochloride (2.73g, 14.3mmol), 1- hydroxybenzotriazole (1.93g, 14.3mmol), and diisopropylethylamine (2.5ml, 14.3mmol) added. The resulting mixture was stirred at room temperature for 17 hours. The mixture was evaporated, and the resulting residue partitioned between CH2Cl2 and water. The organic layer was washed30 with IN HCl, sat. NaHCO3, sat. NaCl, dried over Na2SO4, filtered and evaporated to give the title compound. 1HNMR (500 MHz, CDCl3) delta: 7.57 (s, IH), 4.04 (s, 3H).

88982-82-5 4-Bromo-1,3-thiazole-2-carboxylic acid 15122065, athiazole compound, is more and more widely used in various.

Reference£º
Patent; MERCK & CO., INC.; WO2008/57336; (2008); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica