With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3364-80-5,Thiazole-4-carboxaldehyde,as a common compound, the synthetic route is as follows.
A stirred mixture of 2-amino-4-methyl-pentanoic acid tert-butyl ester, hydrochloride (2. 1G, 9.38 mmol), 1, 3-thiazole-4-carboxaldehyde (Intermediate b) (1. 06 g, 9.38 MMOL) and triethylamine (1.31 mL, 9.38 MMOL) in dichloromethane (25 mL) was heated under reflux under nitrogen for 20 hours. The reaction mixture was allowed to cool to room temperature, washed twice with water, dried over NA2SO4 and evaporated to give the title compound as an oil. ‘H NMR (CDCI3) : 5 8.84 (s, 1H), 8.49 (d, 1 H), 8.01 (s, 1H), 4.00 (dd, 1 H), 1.90-1. 70 (m, 2H), 1.64-1. 56 (m, 1H), 1.47 (s, 9H), 0.96 (d, 3H) and 0.91 (d, 3H)., 3364-80-5
3364-80-5 Thiazole-4-carboxaldehyde 2763214, athiazole compound, is more and more widely used in various.
Reference£º
Patent; GLAXO GROUP LIMITED; WO2004/60889; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica