440100-94-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.440100-94-7,2-Bromothiazole-5-carbonitrile,as a common compound, the synthetic route is as follows.
Step 3: 5-(2-Bromo-1,3-thiazol-5-yl)-2H-tetrazole A solution of 2-bromo-1,3-thiazole-5-carbonitrile (5.00 g, 26.5 mmol) in 2-propanol (75 mL) and water (38 mL) was treated with ZnBr2 (5.96 g, 26.5 mmol) and sodium azide (2.58 g, 39.7 mmol). The reaction mixture was heated at 120 C. for 5 h. The cooled reaction mixture was diluted with water (50 mL) and acidified to pH 3 using aqueous 1 NHCl solution (about 20 mL). The mixture was poured into a 500 mL separatory funnel and the aqueous layer was extracted with EtOAc (4*100 mL). The combined organic layers were washed with brine, dried over Na2SO4, filtered and concentrated under reduced pressure to provide the tetrazole compound.
As the paragraph descriping shows that 440100-94-7 is playing an increasingly important role.
Reference£º
Patent; Isabel, Elise; Lachance, Nicolas; Leclerc, Jean-Philippe; Leger, Serge; Oballa, Renata M.; Powell, David; Ramtohul, Yeeman K.; Roy, Patrick; Tranmer, Geoffrey K.; Aspiotis, Renee; Li, Lianhai; Martins, Evelyn; US2011/301143; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica