Day: September 8, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

A stirred and cooled (-60 0C) sol. of thiazole-2-carbaldehyde (3.97 g, 35.1 mmol) in MeOH (35 mL) was treated with NaBH4 (1.33 g, 35.1 mmol). The reaction mixture was stirred at -60 0C for 2 h, then carefully quenched with acetone (2.7 mL), warmed to rt, and the solvents were removed in vacuo. Purification of the crude by FC (EtOAc) yielded the title compound (3.00 g, 74percent) as an orange oil that crystallized at -20 0C and remained a solid upon warming to rt., 10200-59-6

As the paragraph descriping shows that 10200-59-6 is playing an increasingly important role.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2006/92268; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18903-18-9,Ethyl 5-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.

18903-18-9, Intermediate 4 5-Amino-thiazole-4-carboxylic acid ethyl ester (250mg, 1.453mmol) and triethylamine (1 .02ml_, 7.265mmol) were dissolved in 1 ,4-dioxan (6ml_). To this, 2- chloro-5-(trifluoromethyl)benzene-1 -sulfonyl chloride (0.3mL, 1 .744mmol) was added at room temperature and stirred for 16 hours. The mixture was concentrated in vacuo and extracted with ethyl acetate. The organic layer was washed with 1 N hydrochloric acid solution and water. The organic layer was dried with Na2S04, filtered and concentrated in vacuo. The residue was triturated with n-pentane, the product collected by filtration and dried under vacuum to give Intermediate 4 (340mg). LCMS (Method 26) Rt 2.63 min; m/z(M+H)+ 415

18903-18-9 Ethyl 5-aminothiazole-4-carboxylate 12620181, athiazole compound, is more and more widely used in various.

Reference£º
Patent; ANTABIO SAS; LEMONNIER, Marc; DAVIES, David; PALLIN, David; WO2014/198849; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10200-59-6,2-Thiazolecarboxaldehyde,as a common compound, the synthetic route is as follows.

To a stirred solution of 1.00 g of 1,3-thiazole-2-carboxaldehyde in 10 mL of tetrahydrofuran was added 0.334 g of sodium borohydride at room temperature. To the mixture was dropped 1 mL of methanol, and the mixture was stirred at the same temperature for 30 minutes. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to give 0.344 g of 1,3-thiazol-2-ylmethanol.1H-NMR (CDCl3) delta ppm: 3.11 (1H, br s), 4.97 (2H, s), 7.32 (1H, d, J=3.2Hz), 7.75 (1H, d, J=3.2Hz)

10200-59-6, The synthetic route of 10200-59-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Kissei Pharmaceutical Co., Ltd.; EP1443041; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.95453-58-0,2-Chlorothiazole-5-carbaldehyde,as a common compound, the synthetic route is as follows.

95453-58-0, Example 262A 1-{[(2-chloro-1,3-thiazol-5-yl)methylene]amino}-3-(1,1-dioxido-4H-1,2,4-benzothiadiazin-3-yl)-4-hydroxyquinolin-2(1H)-one The product of Example 226D (0.070 g, 0.196 mmol) was reacted with 2-chloro-1,3-thiazole-5-carbaldehyde (0.157 mL, 1.06 mmol) in N,N-dimethylacetamide (1.2 mL) in a sealed tube at 110 C. for 35 minutes in a microwave reactor. The reaction mixture was cooled to 25 C. and concentrated. The resulting residue was triturated with ethyl acetate and filtered to give the title compound.

As the paragraph descriping shows that 95453-58-0 is playing an increasingly important role.

Reference£º
Patent; Pratt, John K.; Betebenner, David A.; Donner, Pamela L.; Green, Brian E.; Kempf, Dale J.; McDaniel, Keith F.; Maring, Clarence J.; Stoll, Vincent S.; Zhang, Rong; US2004/162285; (2004); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

62266-81-3, 6-Chlorobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,62266-81-3

Reference example 13 6-chloro-3-[2-(dimethylamino)ethyl]-2-benzothiazolone (XIIe) A solution of compound (VIII) (9.28 g, 50 mmol), N,N-dimethylaminoethylchloride hydrochloride (XIe) (7.92 g, 55 mmol), and K2 CO3 (16.58 g, 120 mmol) in acetone (93 ml) was refluxed for 20 hours with stirring. After the reaction was complete, the reaction mixture was concentrated in vacuo. The residue was extracted with ethyl acetate. The layer of ethyl acetate was dried over MgSO4 and subjected to column chromatography on silica gel. From the elude eluted with ethyl acetate, compound (XIIe) (3.3 g, yield=64.3%) was obtained as an oil. IRnumax(nujol)(cm-1):1680,1168. NMR (CDCl3)delta:2.31 (6H, S), 2.59 (2H, t, J=7.2), 4.03 (2H, t, J=7.2), 7.01(1H,d,J=8.6),7.29(1H,d,d,J=8.6,2.2),7.41(1H,d,J=2.2).

As the paragraph descriping shows that 62266-81-3 is playing an increasingly important role.

Reference£º
Patent; Shionogi & Co., Ltd.; US5473066; (1995); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((((1R,3s,5S)-9-azabicyclo[3.3.1]decan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2,6 -dichlorophenyl)isoxazole trifluoroacetate (500 mg, crude), methyl 2-bromobenzo[d]thiazole-6-carboxylate(272 mg, 1.0 mmol) and cesium carbonate (1.0 g, 3 mmol of) was added to the DMA (5 mL), the reaction microwave 120 0.5 hours, and pouredinto water (20mL), filtered (filter cake was purified by silica gel column chromatography in dichloromethane: methanol = 20: 1) to give the desired product ( 200 mg,two-step yield 49.2%).

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; Chen Bo; (66 pag.)CN109265471; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

72850-52-3, Ethyl 2-chloro-4-(trifluoromethyl)thiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

72850-52-3, EXAMPLE 49 STR65 Ethyl 2[(diphenylmethyl)amino]-4-(trifluoromethyl)-5thiazolecarboxylate A reaction vessel was charged with 120 ml of toluene and 11.0 g (42.4 mmol) of ethyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate (prepared as described in U.S. Pat. No. 4,199,506). Then, 15.5 g (86 mmol) of aminodiphenylmethane was added in one portion. The resulting yellowish-orange solution was refluxed under nitrogen for 9 days. Then, solvent was removed from the mixture under reduced pressure to yield a yellowish-orange solid material, which was flash chromatographed (~38 ml/min) on silica gel using 10% ethyl acetate in hexane solvent. There was obtained 13.2 g of a thick yellow oil which solidified upon standing to a yellow solid product (m.p.=92-95 C.) identified in Table I.

As the paragraph descriping shows that 72850-52-3 is playing an increasingly important role.

Reference£º
Patent; Monsanto Company; US5000775; (1991); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.38205-60-6,1-(2,4-Dimethylthiazol-5-yl)ethanone,as a common compound, the synthetic route is as follows.

EXAMPLE 23 1-(2,4-Dimethyl-5-thiazolyl)-1-(3-pyridyl)ethanol 5-Acetyl-2,4-dimethylthiazole (2.5 g) in dry diethylether (10 ml) was added dropwise to a stirred solution of 3-lithiopyridine (from 3.5 g 3-bromopyridine) in diethylether at -70 C. After 3 hours the mixture was allowed to warm to room temperature. After a further 1 hour, aqueous sodium hydrogen carbonate was added and the organic layer was separated. The aqueous layer was extracted with diethylether. The material obtained from the combined organic layers was purified by flash chromatography to give the title compound, m.p. 107.5-109 C. 13 C Nmr (CDCl3) 16.3, 18.7, 32.7, 71.9, 123.1, 133.5, 137.9, 142.4, 146.9, 148.0 and 162.2 ppm.

38205-60-6, As the paragraph descriping shows that 38205-60-6 is playing an increasingly important role.

Reference£º
Patent; Astra Aktiebolag; US5607956; (1997); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

41731-39-9, 2-Bromo-4-(trifluoromethyl)thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of oxetan-3-yl 4-(1-(phenylsulfonyl)-2-(tributylstannyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperazine-1-carboxylate (250 mg, 342 mupiiotaomicron), 2-bromo-4- (trifluoromethyl)thiazole (120 mg, 513 muiotaetaomicron), Cul (65 mg, 342 mmol), and Pd(PPh3)4 (197 mg, 171 muetaiotaomicron) in toluene (10 mL) was degassed with N2, and then stirred at 100C for 16 h under N2. The mixture was cooled to room temperature and concentrated. The residue was directly purified by silica gel chromatography (ethyl acetaterpetroleum ether = 3: 10) to give the title product (70 mg, yield 35%) as a light yellow solid. MS (ES+) C25H22F3N5O5S2 requires: 593, found: 594 [M+H]+.

41731-39-9, 41731-39-9 2-Bromo-4-(trifluoromethyl)thiazole 23149887, athiazole compound, is more and more widely used in various.

Reference£º
Patent; BLUEPRINT MEDICINES CORPORATION; BRUBAKER, Jason D.; FLEMING, Paul E.; KIM, Joseph L.; WILLIAMS, Brett; HODOUS, Brian L.; (238 pag.)WO2019/79649; (2019); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

533-30-2,533-30-2, 6-Aminobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[00405] Step 2: A mixture of 6-chloro-4-((lS,2S)-2,3-dihydroxy-l- phenylpropylamino)nicotinonitrile (0.108 g, 0.356 mmol), benzo[d]thiazol-6-amine (0.187 g, 1.244 mmol) and NMP (1.422 mL) was stirred at 150 ¡ãC for 1 hour in a microwave reactor. The vessel was cooled to room temperature, diluted with water and filtered. Following drying on a buchner funnel, 6-(benzo[d]thiazol-6-ylamino)-4- ((lS,2S)-2,3-dihydroxy-l-phenylpropylamino)nicotinonitrile (0.122 g, 0.292 mmol, 82 percent yield) was collected as a yellowish solid. LC-MS (m/z, M+l= 418), Waters sunfire 4.6x50mm C18 5um 4 min/1 min hold time 0-100percent (A-B) A=10percent MeOH-90percent water – 0.1percentTFA, B=90percent MeOH-10percent water – 0.1percentTFA RT= 2.06.

The synthetic route of 533-30-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; DODD, Dharmpal, S.; MUSSARI, Christopher, P.; BHIDE, Rajeev, S.; NAIR, Satheesh Kesavan; PAIDI, Venkatram Reddy; KUMAR, Sreekantha Ratna; BANERJEE, Abhisek; SISTLA, Ramesh; PITTS, William, J.; HYNES, John; WO2013/106614; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica