Downstream synthetic route of 1024583-33-2

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

1024583-33-2, Methyl 2-bromobenzo[d]thiazole-6-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-((((1R,3s,5S)-9-azabicyclo[3.3.1]decan-3-yl)oxy)methyl)-5-cyclopropyl-3-(2,6 -dichlorophenyl)isoxazole trifluoroacetate (500 mg, crude), methyl 2-bromobenzo[d]thiazole-6-carboxylate(272 mg, 1.0 mmol) and cesium carbonate (1.0 g, 3 mmol of) was added to the DMA (5 mL), the reaction microwave 120 0.5 hours, and pouredinto water (20mL), filtered (filter cake was purified by silica gel column chromatography in dichloromethane: methanol = 20: 1) to give the desired product ( 200 mg,two-step yield 49.2%).

1024583-33-2, The synthetic route of 1024583-33-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Fang Wenkui; Chen Bo; (66 pag.)CN109265471; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica