14527-41-4, 5-Thiazolecarboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example IX.1 (general route) (R)-Benzyl 3-(4-((S)-1 -(thiazole-5-carboxamido)ethyl)phenoxy)pyrrolidine-1 – carboxylate _ – 86 – 3.80 g (10.1 mmol) of example VIII in 20 ml_ DMF are charged with 5.15 ml_ (29.9 mmol) DIPEA, 3.80 g (11.5 mmol) TBTU and finally after 10 min with 1.29 g (9.99 mmol) thiazole-5-carboxylic acid. The reaction mixture is stirred at r.t. over night. The next day water is added and the mixture is extracted with EtOAc (3x). The organic layers are combined, dried over MgS04, filtered and the solvent is removed in vacuo. The crude product is purified by flash chromatography (silica gel, EtOAc). Then the product is added to EtOAc and washed with a saturated aq. NaHCO3 solution (3x), dried over MgSO4, filtered and the solvent is removed in vacuo. C24H25N3O4S (M= 451.5 g/mol) ESI-MS: 452 [M+Hf Rt (HPLC):0.92 min (method D), 14527-41-4
14527-41-4 5-Thiazolecarboxylic acid 84494, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; HEIMANN, Annekatrin; HEINE, Niklas; NOSSE, Bernd; ROTH, Gerald Juergen; WO2014/170197; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica