With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1759-28-0,4-Methyl-5-vinylthiazole,as a common compound, the synthetic route is as follows.
At room temperature, (Rs) imine 2 (0.3 mmol) and the additive (0.315 mmol) was dissolved in 3 mL THF with vigorous stirring for about half an hour. The resulted clear solution was added to the priorly prepared benzothiazol-2-yl metallic reagent (0.45 mmol in 3 mL THF) at -78 C. The reaction was accomplished rapidly within 10 min (monitored by TLC). Then the reaction was quenched with aqueous saturated NH4Cl, extracted with DCM (10 mL ¡Á 3), washed by brine (10 mL), dried over Na2SO4, and concentrated under vacuum. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate 3:1-1:1). The diastereoselectivity was determined by 1H NMR analysis of the crude product., 1759-28-0
The synthetic route of 1759-28-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Zhang, Jinlong; Yang, Yuhong; Wang, Mei; Lin, Li; Wang, Rui; Tetrahedron Letters; vol. 53; 51; (2012); p. 6893 – 6896;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica