Day: September 11, 2020

886361-30-4, Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In an inert atmosphere, copper(II)bromide (47.3 mmol, 1.0 eq) was suspended in MeCN (200 mL) and cooled to 5-10 C. followed by the addition of 3-methylbutylnitrite (71 mmol, 1.45 eq) over 15 min. To this reaction mixture the respective 2-aminothiazole derivative (47.3 mmol, 1 eq) was added in portions over 35 min at 5-10 C. The reaction mixture was then carefully heated to 65 C. and stirring continued for 2 h. The volatiles were removed under reduced pressure and the black residue was purified by FC (heptane/EtOAc, as the appropriate mixture) to give the products as slightly yellow oils or solids

886361-30-4, 886361-30-4 Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate 2782963, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Aissaoui, Hamed; Boss, Christoph; Gude, Markus; Koberstein, Ralf; Sifferlen, Thierry; US2010/222328; (2010); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

56012-38-5,56012-38-5, (2-Methylthiazol-5-yl)methanol is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Methanesulfonyl chloride (0.066 mL, 0.85 mmol) was added to (2-methylthiazol-5-yl)methanol (100mg, 0.77 mmol) and triethylamine (0.215 mL, 1.55 mmol) in DCM (3mL) at 0C over a period of 1 minute under nitrogen. The resulting solution was stirred at 0 C for 1 hour, then evaporated, redissolved in DCM (5m1) and washed with water (5m1). The organic phase was dried using a phase separator cartridge, evaporated and dried under vacuum to give (2-methylthiazol-5 -yl)methyl methanesulfonate (124 mg, 77 %) as animpure colourless gum which was used crude in the next stage. m/z: ES+ [M+H]+ not seen.

56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

intermediate 69:6-bromo-W-[2-chloro-6-{4-morpholinylmeth^amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 2-ch.oro-6-(4- morpholinylmethyl)-4-pyrimidinamine (1.356 g, 5.93 mmol) and 6-bromo-2-chloro-1 ,3- benzothiazo.e (1 ,474 g, 5.93 mmol) in dry A/,A/-dimethy.forrnamide (30 mL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in mineral oil, 0.474 g, 1 1.86 mmol). The reaction mixture was stirred with cooling for 1 hour and at ambient temperature for a further 1 hour. The mixture was treated cautiously with saturated ammonium chloride (7.5 mL). Saturated aqueous sodium carbonate was added (aqueous pH=11 ) and the product was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried using a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica using a gradient elution from 0 to 100 % ethyl acetate in cyciohexane followed by 0 to 30 % methanol in dichloromethane to afford the title compound (1.7 g, 3.86 mmol, 65 % yield). LCMS (Method D): Rt 1.19 minutes; m/z 440, 442 (MH+).

The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David; WO2012/35055; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.11 2-(2-(2-Chlorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (15) Compound 15 was prepared through 2-chlorophenylacetic acid, obtained a white solid in 79% yield. Mp 171.3-172.5 C. 1H NMR (400 MHz, DMSO-d6) delta 8.00 (dd, J = 8.0, 3.6 Hz, 2H), 7.83 (t, J = 8.0 Hz, 1H), 7.53-7.45 (m, 3H), 7.38-7.34 (m, 2H), 4.62 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.3, 163.8, 141.5, 135.2, 134.3, 132.79, 132.77, 129.6, 129.5, 127.7, 127.6, 126.7, 125.5, 122.7, 41.8. IR (KBr, cm-1): 1700, 1685. HRMS-ESI (m/z) calcd for C15H10ClNO2S [M+H+] 304.0199, found 304.0197., 2634-33-5

2634-33-5 1,2-Benzothiazol-3-one 17520, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3034-55-7,5-Bromothiazole,as a common compound, the synthetic route is as follows.

A mixture of 5-bromothiazole (200 mg, 1.2 mmol), (2-nitrophenyl)boronic acid (306 mg, 1.8 mmol), Na2CO3 (259 mg, 2.4 mmol) and Pd(PPh3)4(141 mg, 0.1 mmol) in DMA (5 mL) was degassed with nitrogen, heated to 150 C. and stirred for 2 hours under nitrogen atmosphere and microwave. The reaction was cooled to r.t, filtered and concentrated in vacuo. The residue was diluted with water, extracted with EA. The combined organic layer was washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography to give 5-(2-nitrophenyl)thiazole (130 mg, 52% yield) as a yellow solid. LC/MS (ESI, m/z): [M+1]+=207.2

3034-55-7, 3034-55-7 5-Bromothiazole 546059, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; Kymera Therapeutics, Inc.; Ji, Nan; Kluge, Arthur F.; Weiss, Matthew M.; Zhang, Yi; (180 pag.)US2020/10468; (2020); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4,615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In a four-neck reactor equipped with a thermometer,In a nitrogen stream,10.0 g (60.5 mmol) of 2-hydrazinobenzothiazole was dissolved in 150 ml of DMF.To this solution,39.4 g (121.0 mmol) of cesium carbonate and 9.65 g (72.5 mmol) of 1-bromo-2-butyne were added and the whole of the mixture was stirred at 25 C. for 20 hours.After completion of the reaction, the reaction solution was poured into 1000 ml of water and extracted with 500 ml of ethyl acetate. After drying the ethyl acetate layer with anhydrous sodium sulfate, sodium sulfate was filtered off. Ethyl acetate was distilled off from the filtrate under reduced pressure using a rotary evaporator to obtain a brown solid. This brown solid was purified by silica gel column chromatography (n-hexane: ethyl acetate = 85: 15) to obtain 6.25 g of Intermediate S (yield: 47.5%) as a white solid.

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; ZEON CORPORATION; SAKAMOTO, KEI; OKUYAMA, KUMI; SANUKI, KANAKO; (77 pag.)JP2017/206554; (2017); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

693-95-8, 4-Methylthiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

693-95-8, tep 2: Synthesis of tert-butyl N-[(lS)-l-[4-(4-methyl-l,3-thiazol-5- yl)phenyl] ethyl] carbamate (P)[0421] To a stirred solution of tert-butyl N-[(lS)-l-(4-bromophenyl)ethyl]carbamate (O,15.0 g, 49.97 mmol) in DMA (100 mL), under an atmosphere of nitrogen, was added 4-methyl- 1,3-thiazole (9.9 g, 99.84 mmol), potassium acetate (9.8 g, 99.86 mmol) and Pd(OAc)2(112.5 mg, 0.50 mmol) at rt. The resulting mixture was then stirred at 120C for 2h. The reaction mixture was then cooled to rt, diluted by water (120mL), and extracted with ethyl acetate (200 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and then concentrated under reduced pressure to give a crude residue, which was purified by flash silica gel chromatography (eluent: ethyl acetate/petroleum ether, v: v = 1:5) to give P (yield: 47%) as a white solid. LC-MS (ES+): m/z 319.13 [MH+], tR= 0.97 min (2.0 minute run).

693-95-8 4-Methylthiazole 12748, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ARVINAS, INC.; JIN, Meizhong; CREW, Andrew, P.; DONG, Hanqing; WANG, Jing; SIU, Kam; FERRARO, Caterina; CHEN, Xin; QIAN, Yimin; (351 pag.)WO2016/118666; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

5398-36-7, Ethyl 2-aminothiazole-4-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5398-36-7, 2-Amino-thiazole-4-carboxylic acid ethyl ester (1.4 g, 8 mmol) is dissolved in acetonitrile (15 ml) and N-bromosuccinimide. (1.7 g, 9.6 mmol, 1.2 equiv.) was added in one portion. The mixture was stirred at room temp. for 3 hours, then filtered and the filtrate was evaporated. After purification on silica-gel with ethyl acetate/n-heptane as eluent, 0.71 g of an off-white solid were obtained: MS: m/e 248.9 (M-H).

As the paragraph descriping shows that 5398-36-7 is playing an increasingly important role.

Reference£º
Patent; Gubler, Marcel; Haap, Wolfgang; Hebeisen, Paul; Kitas, Eric A.; Kuhn, Bernd; Minder, Rudolf E.; Schott, Brigitte; Wessel, Hans P.; US2007/281979; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

615-21-4, 2-Hydrazinylbenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

615-21-4, 3.0 g of a compound represented by the formula (I-6-16), 4.6 g of 1-iodohexane, 8.9 g of cesium carbonate, and 20 mL of dimethyl sulfoxide were put into a reactor and heated with stirring. After ordinary post-treatment, this was purified through column chromatography to give 2.3 g of a compound represented by the formula (I-6-17).

As the paragraph descriping shows that 615-21-4 is playing an increasingly important role.

Reference£º
Patent; DIC Corporation; Horiguchi, Masahiro; Kadomoto, Yutaka; (139 pag.)US2018/22716; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1603-91-4, 4-Methylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of appropriate 2-substituent-1H-benzimidazole-4-carboxylic acid (1 mmol), EDC¡¤HCl (0.29 g, 1.5 mmol), HOBt (0.20 g, 1.5 mmol) and Et3N (0.15 g, 1.5 mmol) in DMF (10 mL) was stirred for 1 h at 0 C. Then appropriate amine (1.05 mmol) was added to the solution. The solution was heated up to 25 C, stirred for 12 h and then evaporated to dryness. The solid was washed with water and dried. The products were purified on silica gel column using 10:1 ethyl acetate/ethanol.

1603-91-4, 1603-91-4 4-Methylthiazol-2-amine 74143, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Xue, Fei; Luo, Xianjin; Ye, Chenghao; Ye, Weidong; Wang, Yue; Bioorganic and Medicinal Chemistry; vol. 19; 8; (2011); p. 2641 – 2649;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica