80945-86-4,80945-86-4, 6-Bromo-2-chlorobenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
intermediate 69:6-bromo-W-[2-chloro-6-{4-morpholinylmeth^amineIn an atmosphere of nitrogen, an ice-cooled solution of a mixture of 2-ch.oro-6-(4- morpholinylmethyl)-4-pyrimidinamine (1.356 g, 5.93 mmol) and 6-bromo-2-chloro-1 ,3- benzothiazo.e (1 ,474 g, 5.93 mmol) in dry A/,A/-dimethy.forrnamide (30 mL) was treated portionwise over 5 minutes with sodium hydride (60% w/w in mineral oil, 0.474 g, 1 1.86 mmol). The reaction mixture was stirred with cooling for 1 hour and at ambient temperature for a further 1 hour. The mixture was treated cautiously with saturated ammonium chloride (7.5 mL). Saturated aqueous sodium carbonate was added (aqueous pH=11 ) and the product was extracted with dichloromethane (2 x 100 mL). The organic layers were combined, dried using a hydrophobic frit and evaporated to dryness. The residue was purified by chromatography on silica using a gradient elution from 0 to 100 % ethyl acetate in cyciohexane followed by 0 to 30 % methanol in dichloromethane to afford the title compound (1.7 g, 3.86 mmol, 65 % yield). LCMS (Method D): Rt 1.19 minutes; m/z 440, 442 (MH+).
The synthetic route of 80945-86-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; GLAXO GROUP LIMITED; BARTON, Nicholas Paul; CAMPOS, Sebastien Andre; CARR, Robin Arthur; HARLING, John David; SMITH, Ian Edward David; WO2012/35055; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica