Day: September 14, 2020

53332-78-8, Thiazol-2-ylmethanamine dihydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

53332-78-8, Step 2.5-(methylthio)-N-(thiazol-2-ylmethyl)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7- amine A mixture of crude 5-(methylthio)-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-yl trifluoromethanesulfonate (130 mg, 0.43 mmol), 2-(aminomethyl)thiazole dihydrochloride (99 mg, 0.529 mmol) and DIPEA (0.33 mL, 1.89 mmol) in 1,4-dioxane (2.0 mL) was stirred at room temperature 16.5 h. All volatiles were removed by rotary evaporation, and the crude residue was purified by chromatography on silica gel (gradient 0-20% methanol in DCM) to afford the title compound (22 mg, 18% over 2 steps) as an off-white solid: ESI MS m/z 280 [M + H]+; 1H NMR (500 MHz, DMSO-d6) G 9.99 (t, J = 6.0 Hz, 1H), 8.45 (s, 1H), 7.76 (d, J = 3.3 Hz, 1H), 7.67 (d, J = 3.3 Hz, 1H), 4.97 (d, J = 6.1 Hz, 2H), 2.50 (s, 3H).

The synthetic route of 53332-78-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1003-32-3, Thiazole-5-carboxyaldehyde is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 3:Ammonium formate (8.75 g), thiazole-5-carbaldehyde (5.23 g), and isonitrile 3 (12.0 g) were dissolved in MeOH (100 mL) and heated to reflux for 4 h. The solution was concentrated to approximately 20 mL of MeOH and EtOAc (200 mL) was added. The mixture was filtered and the solvent evaporated to yield a light brown solid. Trituration with ether provided a white solid (5.70 g), which was used without further purification in the following step. MS (ESI) 350 (M+H)., 1003-32-3

The synthetic route of 1003-32-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; SCHERING CORPORATION; N. V. ORGANON; HO, Ginny, D.; SEGANISH, William, M.; TULSHIAN, Deen, B.; TIMMERS, Cornelis Marius; RIJN, Rachel Deborah Van; LOOZEN, Hubert Jan Jozef; WO2011/8597; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31699-14-6,2-Amino-4-(4-iodophenyl)thiazole,as a common compound, the synthetic route is as follows.

General procedure: The general protocol followed by us in obtaining 2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide compounds 4a-o is illustrated for the synthesis of N-(4-phenyl-1,3-thiazol-2-yl)-2-(2,4-dioxo-1,3-thiazolidin-5-yl)acetamide (4a) as an example. A solution of compound 1 (0.4 g, 2.55 mmol) in DCM (10 mL) is cooled to 0 C and then charged with HOBT (0.36 g, 2.4 mmol), followed by HBTU (0.90 g, 2.4 mmol). The reaction mixture is stirred at 0 C for 45 min. After that, a solution of 4-phenylthiazol-2-amine, 3a (0.29 g,1.70 mmol) and DIEA (0.8 mL, 5.1 mmol) in a mixture of DCM (5 mL) and DMF (2.5 mL) is added drop wise over 5 min. The reaction temperature is initially maintained at 0 C for 1 h and later at RT for 10 h. Completion of reaction is evidenced by TLC analysis. After evaporating the DCM solvent on rotavapor, the reaction mixture is diluted with 40 mL of distilled water and extracted with (3 15 mL) of ethyl acetate. The combined organic layer is washed with saturated aqueous sodium bicarbonate solution (2 10 mL), followed by saturated aqueous sodium chloride solution (2 20 mL). After drying over anhydrous sodium sulfate, the organic layer is filtered and the filtrate is stripped off the solvent. The crude product thus obtained is purified by column chromatography over silica gel. The rest of the 2-(thiazolidinedion-5-yl)acetamide derivatives (4b-o) are prepared similarly by reacting 2,4-dioxo-1,3-thiazolidine-5-acetic acid (1) with the appropriate amine (3b-o)., 31699-14-6

The synthetic route of 31699-14-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Koppireddi, Satish; Komsani, Jayaram Reddy; Avula, Sreenivas; Pombala, Sujitha; Vasamsetti, Satishbabu; Kotamraju, Srigiridhar; Yadla, Rambabu; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 305 – 313;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

63837-11-6,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63837-11-6,5-Bromo-2-methylbenzothiazole,as a common compound, the synthetic route is as follows.

EXAMPLE 17A 4-(2-methyl-1,3-benzothiazol-5-yl)benzoic acid The desired product was prepared by substituting 5-bromo-2-methyl-1,3-benzothiazole for 6-bromoindole in Example 4A. MS (DCI) m/e 270 (M+H)+.

The synthetic route of 63837-11-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/55631; (2002); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

199475-45-1, 5-Bromobenzo[d]thiazol-2(3H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 5-bromo-3H-1,3-benzothiazol-2-one (94.4 mg,0.410 mmol)in water(2.1 mL)was added NaOH (16.4 mg,0.410 mmol)and then dimethyl sulfate (62.1 mg,0.492mmol). After stirring at room temperature for 3 h,the resulting precipitate was filtered,washedwith water,and dried under reduced pressure to give the title compound (89.3 mg,89%)as awhite powder that required no further purification. 1H NMR (400 MHz,CDCl3)8 7.32- 7.2915 (m,2H),7.20 (dd,J = 1.5,0.6 Hz,1H),3.45 (s,3H).

199475-45-1, 199475-45-1 5-Bromobenzo[d]thiazol-2(3H)-one 2801273, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; GENENTECH, INC.; CONSTELLATION PHARMACEUTICALS, INC.; CYR, Patrick; BRONNER, Sarah; ROMERO, F. Anthony; MAGNUSON, Steven; TSUI, Vickie Hsiao-Wei; WAI, John; LAI, Kwong Wah; WANG, Fei; (251 pag.)WO2017/205536; (2017); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2289-75-0, 4,5-Dimethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1N-(4,5-dimethylthiazol-2-yl)-2-[5-(6,7-dimethoxyquinazolin-4-yloxy)pyridin-2- yl]acetamideTriethylamine (0.245 ml) and 2-(7-azabenzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluoropliosphate(V) (0.236 g) were added in turn to a stirred mixture of2-[5-(6,7-dimethoxyquinazolin-4-yloxy)pyridin-2-yl]acetic acid (0.2 g), 2-amino- 4,5-dimethylthiazole (0.083 g) and DMF (2 ml) and the resultant mixture was stirred at ambient temperature for 40 minutes. A mixture of a saturated aqueous sodium bicarbonate solution (5 ml) and a saturated aqueous sodium carbonate solution (5 ml) was added and the resultant mixture was stirred at ambient temperature for 1 hour. The precipitate was isolated and triturated under diethyl ether. The resultant solid was dried under vacuum at 400C for 16 hours. There was thus obtained the title compound as a solid (0.185 g); 1H NMR: (DMSOd6) 2.1 (s, 3H), 2.2 (s, 3H), 4.0 (m, 8H), 7.4 (s, IH), 7.5 (d, IH), 7.6 (s, IH), 7.8 (m, IH), 8.5 (m, IH), 8.55 (s, IH): Mass Spectrum: M-H’ 450., 2289-75-0

The synthetic route of 2289-75-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/99317; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.133840-96-7,2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: 2-Chloro-6-trifluoromethoxy-benzothiazole (1.27 g, 5 mmol)was dissolved in 10 mL ethylamine aqueous solution. Theresultant mixture was stirred at room temperature overnight.The solvent was removed under reduced pressure. Theresidue was dissolved in CH2Cl2 and washed three timeswith water, dried over anhydrous Na2SO4, filtered and thesolvent completely removed. The crude material was purifiedby column chromatography over silica used dichloromethaneas eluent to give compound 4a as a whiteamorphous powder (1.11 g, 84.7%). Compounds 4b-4iwere also prepared by the same procedure from compound3 with n-butylamine, diaethylamin, cyclohexylamine, pyrrolidine,piperidine, morpholine, and 4-methylpiperidine,respectively. Spectroscopic data of N-alkylated derivativesof riluzole were given as follow., 133840-96-7

133840-96-7 2-Chloro-6-(trifluoromethoxy)benzo[d]thiazole 10037924, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Wu, Xiang-Long; Liu, Liu; Li, You-Jia; Luo, Jie; Gai, Dong-Wei; Lu, Ting-Li; Mei, Qi-Bing; Medicinal Chemistry Research; vol. 27; 5; (2018); p. 1374 – 1383;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

247037-82-7, Thiazole-2-carboximidamide hydrochloride is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of thiazole-2-carboximidamide hydrochloride (5.49 g, 33.6 mmol) and sodium bicarbonate (5.64 g, 67.1 mmol) in NMP (46 ml) at 120 C. was added a solution of the compound from Step 2-2a (8.80 g, 33.6 mmol) in NMP (20 ml). The mixture was heated at 120 C. under N2 for 2.5 h before being allowed to cool down and diluted with MTBE and water. The organic layer was washed with water (*1), brine (*1), dried over Na2SO4 (s), filtered and concentrated. The residue was purified by flash column chromatography (silica, hexanes/EtOAc) to afford the desired compound as yellow oil (5.10 g, 41%). ESI MS m/z=372.13 [M+H]+., 247037-82-7

As the paragraph descriping shows that 247037-82-7 is playing an increasingly important role.

Reference£º
Patent; ENANTA PHARMACEUTICALS, INC.; Qiu, Yao-Ling; Cao, Hui; Peng, Xiaowen; Li, Wei; Kass, Jorden; Gao, Xuri; Jin, Meizhong; Or, Yat Sun; (49 pag.)US2017/355701; (2017); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109113-98-6,6-(Trifluoromethyl)imidazo[2,1-b]thiazole,as a common compound, the synthetic route is as follows.

At 00C POCl3 (17.1 mmol) is added dropwise to a solution of DMF (20.6 mmol) in chloroform (5.0 mL). A solution of 6-trifluoromethyl-imidazo[2,l-b]thiazole (3.17 mmol) in chloroform (15 mL) is added dropwise at 00C and the mixture is stirred for 3h at RT. After heating for 2.5d to reflux the mixture is poured into ice, extracted three times with DCM, dried over MgSO4 and concentrated under reduced pressure. DCM is added, the obtained precipitate is filtered off and the filtrate is concentrated in vacuo to give a crude product which is dissolved in tert.-butanol (19.5 mL). A solution of sodium chlorite (23.0 mmol) and sodium dihydrogen phosphate dihydrate (17.6 mmol) in water (19.5 mL) is added dropwise and the mixture is stirred for 90 min at RT. The solvents are partially removed in vacuo and the obtained precipitate is filtered off to give the desired product as a white solid. LC-MS: tR = 0.73 min; [M+H]+ = 237.2.

109113-98-6, 109113-98-6 6-(Trifluoromethyl)imidazo[2,1-b]thiazole 11084696, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/16560; (2009); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2786-51-8, 5-Chlorobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,2786-51-8

General procedure: A mixture of benzothiazole 1a (67.5 mg, 0.5 mmol), cyclohexane-1,3-dione 2b (112 mg, 1 mmol), KH2PO4 (136 mg, 1 mmol), DMSO (2 mL) and water (2 mL) were placed into a 15 mL flask under air. The reaction mixture was stirred in oil bath for 3 days at 80 C. The progress of the reaction was monitored by TLC. When the reaction was complete, it was neutralised with a saturated KHCO3 aqueous solution, and extracted with ethyl acetate (3 ¡Á10 mL). The extract was washed with water (3 ¡Á 5 mL) and dried over anhydrous Na2SO4. After drying, it was concentrated under reduced pressure to give the crude product, which was further purified by silica-gel column chromatography to afford 2,3-dihydro-10H-phenothiazin-4 (1H)-ones 3b (93.2 mg, yield: 86%).

As the paragraph descriping shows that 2786-51-8 is playing an increasingly important role.

Reference£º
Article; Suliman, Ayman Mohammed Yousif; Li, Yanjun; Zhang, Shaonan; Yuan, Yu; Journal of Chemical Research; vol. 39; 11; (2015); p. 657 – 660;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica