Day: September 15, 2020

67899-00-7, 2-Amino-4-methylthiazole-5-carboxylic acid is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,67899-00-7

To a suspension of 6 (500mg, 3.20mmol) in tetrahydrofuran (20mL) were added pyridine (1.30mL, 16.0mmol) and acetyl chloride (0.60ml, 7.90mmol) at 0C, and the reaction mixture was stirred for 21h at room temperature. After the volatiles of the mixture were removed in vacuo, water was poured into the residue, and the suspension was stirred for 1h. The resulting precipitate was collected by filtration, washed with water and dried in vacuo to yield 7 (585mg, 91%) as a colorless powder. 1H NMR (200MHz, DMSO-d6) delta 2.15 (s, 3H), 2.52 (s, 3H), 12.35 (br s, 1H); MS (ESI): m/z 201 [M+H]+, 223 [M+Na]+, 199 [M-H]-.

The synthetic route of 67899-00-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Oka, Yusuke; Yabuuchi, Tetsuya; Oi, Takahiro; Kuroda, Shoichi; Fujii, Yasuyuki; Ohtake, Hidenori; Inoue, Tomoyuki; Wakahara, Shunichi; Kimura, Kayo; Fujita, Kiyoko; Endo, Mayumi; Taguchi, Kyoko; Sekiguchi, Yoshinori; Bioorganic and Medicinal Chemistry; vol. 21; 24; (2013); p. 7578 – 7583;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24295-03-2,2-Acetylthiazole,as a common compound, the synthetic route is as follows.

General procedure: To a solution of the appropriate ketone (A, 1 equiv) in chloroform, bromine (1 equiv) in chloroform was added dropwise at 0 C. The mixture was stirred at room temperature for 2 h and was washed with H2O (3 50 ml) and saturated Na2S2O3 solution (2 x 50 ml). The organic phase was dried over Na2SO4, filtered andthe solvent was removed in vacuum. The crude alpha-bromoketone (B) was recrystallized from petrolether.48

24295-03-2, The synthetic route of 24295-03-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Vogt, Dominik; Weber, Julia; Ihlefeld, Katja; Brueggerhoff, Astrid; Proschak, Ewgenij; Stark, Holger; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5354 – 5367;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

4175-77-3, 2,4-Dibromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

he mixture of compound 433a (5 g, 20.5 mmol), cyclopropyl boronic acid (2.12 g, 24.7 mmol), K3P04 (13.1 g, 61.7 mmol), Xantphos (0.6 g, 1.04 mmol) and Pd(OAc)2 (0.23 g, 1.04 mmol) in THF (140 mL) was stirred at 80 ¡ãC under N2 for about 15 hours. The reaction was complete detected by TLC (Petroleum Ether/EtOAc = 30: 1) and LCMS. The mixture was extracted with EtOAc (100 mL), water (50 mL). The combined organics was dried over Na2S04, purified with silica gel (Petroleum Ether /EtOAc = 50: 1) to provide compound 433b as oil (3.48 g, yield: 83.3percent)

4175-77-3, As the paragraph descriping shows that 4175-77-3 is playing an increasingly important role.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; YU, Wensheng; TONG, Ling; KOZLOWSKI, Joseph A.; SELYUTIN, Oleg; CHEN, Lei; KIM, Jae-Hun; SHA, Deyou; RIZVI, Razia; SHANKAR, Bandarpalle; HU, Bin; ZHONG, Bin; WAI, Dahai; HAO, Jinglai; WEI, Wei; JI, Tao; ZAN, Shuai; WO2014/110705; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

63837-11-6, 5-Bromo-2-methylbenzothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

63837-11-6, N-Bromosuccinimide (4.45 g, 25 mmol, 1.4 equiv.) and subsequently alpha,alpha’~ azoisobutyronitrile (110 mg, 0.7 mmol, 0.04 equiv.) were added to a solution of 5- bromo-2-methyl-benzothiazole (4.07 g, 17.85 mmol, 1 equiv.) in CCI4 (110 ml). The reaction mixture was stirred at reflux for 24 hrs. After cooling, succinimide was removed by filtration and was rinsed with CCI4 (100 ml). The filtrate was evaporated to dryness under reduced pressure and the orange solid residue was purified by column chromatography on silica, eluted with CH2CI2/hexane (20%-70% gradient), to give the desired product as a white solid, 2.15 g (39% yield). Mp 116-117, HPLC-MS (method 1): m/z 308 [M+H]+, Rt = 4.84 min. The reaction gave also 1.40 g (20% yield) of the by-product 5-bromo-2-dibromomethyl-benzothiazole, as well as 0.89 g (22%) of un-reacted starting material.

As the paragraph descriping shows that 63837-11-6 is playing an increasingly important role.

Reference£º
Patent; PROLYSIS LTD; WO2007/107758; (2007); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

61296-22-8, 2-Amino-5-bromothiazole monohydrobromide is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a mixture of sodium bicarbonate (5.8 kg, 69.04 mol, 3.00 equiv) in water (30 L) and dichloromethane (20 L) was added 5-bromo-l,3-thiazol-2-amine hydrobromide (6 kg, 23.08 mol, 1.00 equiv) in batches. The resulting mixture was stirred at room temperature for 4 h and extracted with dichloromethane. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum to afford 5-bromo-l,3-thiazol-2-amine as a gray solid (2.9 kg, 70%)., 61296-22-8

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; YU, Jiang; WU, Guosheng; YUEN, Po-Wai; VILLEMURE, Elisia; SCHWARZ, Jacob; LY, Cuong; SELLERS, Benjamin; VOLGRAF, Matthew; WO2015/52226; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.349-49-5,4-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.

(Example 48) 4-Hydroxy-4-(trifluoromethyl)-3-{1-[4-(trifluoromethyl)1,3-thiazol-2-yl]piperidin-4-yl}-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (hereinafter, referred to as compound 48-a)[0476] Copper(II) chloride (2.90 g, 21.57 mmol) was added to a solution of 2-amino-4-(trifluoromethyl)thiazole (3.05 g, 18.14 mmol) in acetonitrile (80 mL), then isoamyl nitrite (3.60 mL, 27.04 mmol) was added dropwise thereto at 0¡ãC, and the mixture was stirred at room temperature for 1 hour and at 50¡ãC for 2 hours. Then, the solvent in the reaction solution was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 100/0 – 70/30 (gradient)] to obtain an oil (1.12 g)._: [0478] 4-Hydroxy-3-(piperidin-4-yl)-4-(trifluoromethyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one (62 mg, 0.18 mmol) produced in Reference Example 60 and N,N-diisopropylethylamine (40 muL, 0.24 mmol) were added to a solution of the obtained oil (55 mg) in dimethyl sulfoxide (2 mL), and the mixture was stirred at room temperature for 5 hours and further at 0¡ãC for 2 hours and 30 minutes. The reaction solution was diluted with ethyl acetate, washed with water and brine, and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography [elute: hexane/ethyl acetate = 70/30 – 10/90 (gradient)] to obtain the title compound 48-a (6 mg, yield: 6percent) and compound 48-b (18 mg, yield: 16percent). Compound 48-a 1H-NMR (400 MHz, DMSO-d6) delta: 12.29 (1H, s), 10.53 (1H, s), 7.54 (1H, s), 6.79 (1H, s), 4.05-3.96 (2H, m), 3.40-3.20 (1H, m), 3.14 (2H, t, J = 12 Hz), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.94-1.74 (4H, m); MS (ESI) m/z: 456 (M+H)+.Compound 48-b 1H-NMR (400 MHz, DMSO-d6) delta: 12.27 (1H, s), 10.54 (1H, s), 8.61 (1H, s), 6.80 (9H, s), 4.10 (2H, d, J = 13 Hz), 3.33-3.18 (3H, m), 2.90 (1H, d, J = 16 Hz), 2.73 (1H, d, J = 16 Hz), 1.99-1.74 (4H, m); MS (ESI) m/z: 607 (M+H)+., 349-49-5

As the paragraph descriping shows that 349-49-5 is playing an increasingly important role.

Reference£º
Patent; Daiichi Sankyo Company, Limited; KOBAYASHI, Hideki; OHKAWA, Nobuyuki; TAKANO, Daisuke; KUBOTA, Hideki; ONODA, Toshio; KANEKO, Toshio; ARAI, Masami; TERASAKA, Naoki; EP2862861; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53266-94-7,Ethyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,53266-94-7

A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl) acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190 ¡ãC for 5 h and then cooled at RT and diluted with 100 mL of CH2CL2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDC13) : 81. 26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7. 86 (m, 10 H) ; Mass Spectrum (NH3-CI): m/z 351 (M+1).

The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2005/14537; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.35272-15-2,2-Methylthiazole-4-carboxylic acid,as a common compound, the synthetic route is as follows.

To 2-methyl-1 ,3-thiazole-4-carboxylic acid (1 g) was added thionyl chloride (5 ml). The mixture was heated at 80 ¡ãC for 8 h. Thionyl chloride (5 ml) was added and the mixture heated for 2 h at 80 ¡ãC. Further thionyl chloride (5 ml) was added and the mixture heated for 2 h. The mixture was concentrated in vacuo and azeotroped with toluene to give the title compound, 1 .12 g.1H NMR (DSMO) delta 8.34 (s, 1 H), 2.80 (s, 3H), 35272-15-2

As the paragraph descriping shows that 35272-15-2 is playing an increasingly important role.

Reference£º
Patent; GLAXO GROUP LIMITED; BALDWIN, Ian Robert; DOWN, Kenneth David; FAULDER, Paul; GAINES, Simon; HAMBLIN, Julie Nicole; JONES, Katherine Louise; LE, Joelle; LUNNISS, Christopher James; PARR, Nigel James; RITCHIE, Timothy John; ROBINSON, John Edward; SMETHURST, Christian Alan Paul; WO2011/67366; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.348-40-3,6-Fluorobenzo[d]thiazol-2-amine,as a common compound, the synthetic route is as follows.

Hydrochloric acid (10 mL) was added dropwise to hydrazine hydrate 99% (10 g, 0.2 mol) at 5-10 C, followed by addition of a solution of 2-amino-6-fluorobenzothiazole (1) (3.364 g, 0.02 mol) in ethylene glycol (40 mL). The mixture was heated at reflux temperature for 5 h. On cooling, the precipitated solid was collected by filtration, washed with water, dried and crystallized from ethanol. Yield 89%, m.p. 194-196 C [1].

348-40-3, As the paragraph descriping shows that 348-40-3 is playing an increasingly important role.

Reference£º
Article; Gabr, Moustafa T.; El-Gohary, Nadia S.; El-Bendary, Eman R.; El-Kerdawy, Mohamed M.; Ni, Nanting; Chinese Chemical Letters; vol. 27; 3; (2016); p. 380 – 386;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5398-36-7,Ethyl 2-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,5398-36-7

Thiazole 4b (0.439 g 2.5 mmol) was dissolved in a mixture ofCH2Cl2:THF (1:1) (10 mL). (Boc)2O (0.577 g, 2.65 mmol) and TEA (0.744 g, 7.36 mmol) were added. The mixture was refluxed for 72 h and then concentrated under reduced pressure. The residue was disolved in AcOEt, washed with HCl 5% v/v (3 x 15 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica flash cromatography AcOEt:EP (3:7). White solid. Yield 74%. 1H NMR ((CD3)2CO, 400 MHz): delta 1.33 (t, 3H,J =7.2 Hz), 1.54 (s, 9H), 4.30 (q, 2H, J = 7.2 Hz), 7.22 (s, 1H), 10.33 (s,1H). 13C NMR ((CD3)2CO, 100 MHz): delta 14.6, 28.2, 61.1, 82.2, 122.4,143.0, 160.4, 161.8.

The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Franco, Jaime; Medeiros, Andrea; Benitez, Diego; Perelmuter, Karen; Serra, Gloria; Comini, Marcelo A.; Scarone, Laura; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 776 – 788;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica