With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5398-36-7,Ethyl 2-aminothiazole-4-carboxylate,as a common compound, the synthetic route is as follows.,5398-36-7
Thiazole 4b (0.439 g 2.5 mmol) was dissolved in a mixture ofCH2Cl2:THF (1:1) (10 mL). (Boc)2O (0.577 g, 2.65 mmol) and TEA (0.744 g, 7.36 mmol) were added. The mixture was refluxed for 72 h and then concentrated under reduced pressure. The residue was disolved in AcOEt, washed with HCl 5% v/v (3 x 15 mL), dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by silica flash cromatography AcOEt:EP (3:7). White solid. Yield 74%. 1H NMR ((CD3)2CO, 400 MHz): delta 1.33 (t, 3H,J =7.2 Hz), 1.54 (s, 9H), 4.30 (q, 2H, J = 7.2 Hz), 7.22 (s, 1H), 10.33 (s,1H). 13C NMR ((CD3)2CO, 100 MHz): delta 14.6, 28.2, 61.1, 82.2, 122.4,143.0, 160.4, 161.8.
The synthetic route of 5398-36-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Franco, Jaime; Medeiros, Andrea; Benitez, Diego; Perelmuter, Karen; Serra, Gloria; Comini, Marcelo A.; Scarone, Laura; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 776 – 788;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica