With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.53266-94-7,Ethyl 2-(2-aminothiazol-4-yl)acetate,as a common compound, the synthetic route is as follows.,53266-94-7
A neat mixture of 54 g (0.29 mole) ethyl (2-aminothiazol-4-yl) acetate and 50 g (0.276 mole) benzophenone imine was stirred at 190 ¡ãC for 5 h and then cooled at RT and diluted with 100 mL of CH2CL2. The entire mixture was transferred onto a silica gel column and eluted with 20percent EtOAc/Hexane. The title compound was obtained as light-yellow solid (70 g, 69percent yield). 1H NMR (300 MHz, CDC13) : 81. 26 (t, 3H), 3.74 (s, 2H), 4.15 (q, 2H), 6.87 (s, 1H), 77.25-7. 86 (m, 10 H) ; Mass Spectrum (NH3-CI): m/z 351 (M+1).
The synthetic route of 53266-94-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; MERCK & CO., INC.; WO2005/14537; (2005); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica