Day: September 17, 2020

55661-33-1, Thiazol-2-ylmethanamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

55661-33-1, To a round bottom flask with a magnetic stirrer bar 2-(aminomethyl)thiazole (0.46 g, 4 mmol) and 4-methoxybenzaldehyde (1 .22 g, 9 mmol) were added together with 10 ml methanol, NaCNBH3 (0.57 g, 9 mmol) and a few granules of 4A molecular sieve. The solution was stirred overnight at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). After filtration the mixture was concentrated in vacuo and the resulting liquid was diluted with 50 ml dichloromethane and extracted with 3×50 ml 0.05 M HCI. The combined aqueous layer was made basic with NaOH until the pH was 10-1 1 and the solution was extracted with 2×150 ml dichloromethane. The organic layers were combined and dried over anhydrous MgS04, filtered and evaporated to give /V,/V-bis(4- methoxybenzyl)-1 -(thiazol-2-yl)methanamine as a dark brown oil. Yield: 1 g (70 %), ,1H NMR (300 MHz, CDCI3): delta 7.73 (1 H, d), 7.29 (5H, m), 6.9 (4H, m), 4.62 (2H, s), 4.13 (2H, s), 3.81 (8H, s),13C NMR (75 MHz, CDCI3): delta 172, 159.2, 158.9, 142.6, 133.4, 131 .8, 129.5, 128.7, 1 18.9, 1 14, 65, 55.4, 52.7, 50.1 .

55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; UNIVERSITETET I OSLO; TASKEN, Kjetil; LYGREN, Birgitte; ?STENSEN, Ellen; KLAVENESS, Jo; WO2013/171332; (2013); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.61296-22-8,2-Amino-5-bromothiazole monohydrobromide,as a common compound, the synthetic route is as follows.

61296-22-8, Di-tert-butyl dicarbonate [(Boc)20, 100.7 g, 0.461 mol, 1.2 eq] was added to a flask containing a mixture of 2-amino-5-bromothiazole monohydrobromide (la?, 100 g, 0.385 mol, 1.0 eq) and 4-(dimethylamino)pyridine (DMAP, 1.18 g, 9.7 mmol, 0.025 eq) in900 mL of THF and 135 mL of Et3N and cooled to 0 C using an ice bath. The reaction mixture was stirred at r.t. overnight and then concentrated in vacuo. The residue was stirred in EtOAc/Heptane (1:10, 250 ml) at rt overnight and then filtered. The filtrate was washed with brine, dried, filtered, and concentrated in vacuo to furnish intermediate lb? as a yellow solid (91% yield).

As the paragraph descriping shows that 61296-22-8 is playing an increasingly important role.

Reference£º
Patent; ARIAD PHARMACEUTICALS, INC.; BENCIVENGA, Nicholas, E.; DALGARNO, David, C.; GOZGIT, Joseph, M.; HUANG, Wei-Sheng; KOHLMANN, Anna; LI, Feng; QI, Jiwei; SHAKESPEARE, William, C.; THOMAS, Ranny, M.; WANG, Yihan; ZHU, Xiaotian; (110 pag.)WO2018/112136; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

1123-99-5, 2-Iodobenzo[d]thiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred, cooled (0 C) solution of 2,2,6,6-tetramethylpiperidine (0.25 mL, 1.5 mmol) in THF (2-3 mL) were successively added BuLi (about 1.6 M hexanes solution, 1.5 mmol) and, 5 min later, ZnCl2?TMEDA14 (0.13 g, 0.50 mmol). The mixture was stirred for 15 min at 0 C before introduction of the substrate (1.0 mmol) at 0-10 C. After 2 h at room temperature, a solution of I2 (0.38 g,1.5 mmol) in THF (4 mL) was added. The mixture was stirred overnight before addition of an aqueous saturated solution of Na2S2O3(4 mL) and extraction with AcOEt (3 20 mL). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. To the crude iodide were added Cs2CO3(0.65 g, 2.0 mmol), Cu powder (13 mg, 0.20 mmol), the azole (1.5 mmol) and MeCN (5 mL) and the resulting mixture was heated under reflux for 24 h. Filtration over Celite, washing with AcOEt,removal of the solvent and purification by chromatography on silica gel (the eluent is given in the product description) led to the compound described below., 1123-99-5

The synthetic route of 1123-99-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Hedidi, Madani; Bentabed-Ababsa, Ghenia; Derdour, Aicha; Roisnel, Thierry; Dorcet, Vincent; Chevallier, Floris; Picot, Laurent; Thiery, Valerie; Mongin, Florence; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3498 – 3507;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7305-71-7,2-Amino-5-methylthiazole,as a common compound, the synthetic route is as follows.

(1) After t-butyl nitrite (1.99 g) was added dropwise to a suspension of 2-amino-5-methyltiazole (2.00 g) in acetonitrile (20 ml) while ice-cooling, copper(II) bromide (4.30 g) was gradually added thereto. This suspension was stirred for 3 hours at 0¡ãC. The reaction solution was charged with 1N hydrochloric acid (100 ml) and then extracted twice with ethyl acetate (200 ml). After the organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated. The residue was purified by silica gel column chromatography (neutral; hexane:ethyl acetate=80:20) to yield 2-bromo-5-methylthiazole (1.31 g) as a yellow oil. 1H NMR (300 MHz, CDCl3) delta ppm: 2.44 (3H, d, J = 1.2 Hz), 7.25 (1H, d, J = 1.1 Hz)

7305-71-7, Big data shows that 7305-71-7 is playing an increasingly important role.

Reference£º
Patent; TAISHO PHARMACEUTICAL CO., LTD; EP1721905; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

405939-39-1, tert-Butyl (5-bromothiazol-2-yl)carbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,405939-39-1

To a solution of tert-butyl N-(5-bromo-l,3-thiazol-2-yl)carbamate (5 g, 17.9 mmol) in tetrahydrofuran (100 ml) was added dropwise LDA (29.4 ml, 2 mol/L) at -78 C, and the resulting mixture was stirred for 1 h at -78C. Then the mixture was added a solution of hexachloroethane (14 g, 59.1 mmol) in tetrahydrofuran (50 ml) at -78 C. The reaction was stirred for additional 15 h at room temperature. The reaction was quenched by water, then extracted with dichloromethane and concentrated in vacuo. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate/petroleum ether (1/9) to afford tert-butyl N-(4-bromo-5-chloro-l,3-thiazol-2-yl)carbamate (4.07 g , 72%) as brown oil. LCMS (ESI): M+H+ = 313.0.

As the paragraph descriping shows that 405939-39-1 is playing an increasingly important role.

Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; YU, Jiang; WU, Guosheng; YUEN, Po-Wai; VILLEMURE, Elisia; SCHWARZ, Jacob; LY, Cuong; SELLERS, Benjamin; VOLGRAF, Matthew; WO2015/52226; (2015); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2634-33-5, 1,2-Benzothiazol-3-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The acid 4 (5 mmol), EDC (1.2 g, 6.26 mmol), HOBt (0.9 g,5.88 mmol), NMM (1.2 mL, 10.74 mmol), and dichloromethane (10 mL) were mixed at ice-bath and stirred at 0 C for half an hour. 1,2-Benzisothiazol-3-one 1 (800 mg, 5.3 mmol) was added to NMM (1.6 mL, 14.32 mmol) in 10 mL of dichloromethane at 0 Ct hen the above mixture was added and stirred at room temperature overnight. After stirring overnight, the mixture was diluted with CH2Cl2, and then successively through washed with water, 5% KHSO4 solution, saturated NaHCO3 solution, and brine, the extract was dried with anhydrous Na2SO4 and evaporated under vacuum. The product was isolated by column chromatography (petroleum ether/CH2Cl2, 10:1) to yield the final compound. 4.2.8 2-(2-(2-Fluorophenyl)acetyl)benzo[d]isothiazol-3(2H)-one (12) Compound 12 was prepared through 2-fluorophenylacetic acid, obtained a white solid in 75% yield. Mp 154.3-155.5 C. 1H NMR (400 MHz, DMSO-d6) delta 7.99 (d, J = 8.0 Hz, 2H), 7.82 (td, J = 8.0, 1.2 Hz, 1H), 7.50 (t, J = 8.0 Hz, 1H), 7.42-7.34 (m, 2H), 7.23-7.17 (m, 2H), 4.52 (s, 2H). 13C NMR (101 MHz, DMSO-d6) delta 170.4, 163.8, 161.3 (d, J = 243 Hz), 141.5, 135.2, 132.7 (d, J = 4.0 Hz), 129.8 (d, J = 8.0 Hz), 127.5, 126.7, 125.5, 124.8 (d, J = 3.0 Hz), 122.7, 121.6 (d, J = 16 Hz), 115.5 (d, J = 21 Hz), 37.5. IR (KBr, cm-1): 1705, 1690. HRMS-ESI (m/z) calcd for C15H10FNO2S [M+H+] 288.0494, found 288.0495., 2634-33-5

As the paragraph descriping shows that 2634-33-5 is playing an increasingly important role.

Reference£º
Article; Li, Zhenghui; Pan, Yang; Zhong, Weilong; Zhu, Yunpeng; Zhao, Yongle; Li, Lixin; Liu, Wei; Zhou, Honggang; Yang, Cheng; Bioorganic and Medicinal Chemistry; vol. 22; 24; (2014); p. 6735 – 6745;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

3034-55-7, 5-Bromothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-Bromothiazole (1.55 g, 9.0 mmol), piperidine (2.7 mL, 27.0 mmol), sodium tert-butoxide (1.78 g, 18.0 mmol), Rh(cod)2BF4 (73 mg, 2.0 mol %), 1,3-diisopropylimidazolium chloride (70 mg, 4.0 mol %) and 1,2-dimethoxyethane (9 mL) were mixed under argon atmosphere. The reaction mixture was vigorously stirred at 80 C overnight, then it was cooled down to room temperature and diluted with AcOEt. The crude reaction was filtered through a pad of silica gel, the organic solvents were evaporated and the residue was purified by flash chromatography on silica gel using as eluent CH2Cl2/AcOEt 10:0.5, then 10:1, to afford a slightly yellow oil (1.40 g; 92%). Found: C 57.49, H 6.92, N 16.48. C8H12N2S requires C 57.11, H 7.19, N 16.65%. IR (Nujol, cm-1): 1651 (CN), 1558 (CC), 1539 (CC). 1H NMR (400 MHz, CDCl3): delta 8.16 (s, 1H), 7.01 (s, 1H), 3.15-3.05 (m, 4H), 1.75-1.68 (m, 4H), 1.60-1.53 (m, 2H). 13C NMR (75 MHz, CDCl3): delta 156.0, 140.5, 122.3, 53.5, 25.1, 23.5. HRMS (ESI+): found 169.0789 [M+H]+. C8H13N2S requires 169.0794., 3034-55-7

As the paragraph descriping shows that 3034-55-7 is playing an increasingly important role.

Reference£º
Article; Galan, Elena; Andreu, Raquel; Garin, Javier; Mosteo, Laura; Orduna, Jesus; Villacampa, Belen; Diosdado, Beatriz E.; Tetrahedron; vol. 68; 32; (2012); p. 6427 – 6437;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

16629-15-5, 2-Bromo-5-chlorothiazole is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of 2-bromo-5-chlorothiazole (0.068 g, 0.34 mmol, 1.0 eq) in 1,4-dioxane (2.0 mL) was added compound 199.3 (0.10 g, 0.41mmol, 1.2eq) followed by addition of 1M aq. Na2C03 (0.68 mL, 0.68 mmol, 2.0 eq). Reaction mixture was degassed with argon for 10 min and Pd(PPh3)4 (0.037g, 0.034mmol, O. leq) was added. Reaction mixture was stirred at 100 C for 16 h. After completion of reaction was quenched with water and extracted with EtOAc. Organic layers were combined, washed with brine, dried over Na2S04 and concentrated under reduced pressure to obtain crude material. The crude was purified by column chromatography to furnish 1.4. (0.025 g, 23.0 %). MS(ES): m/z 314.4 [M]+

16629-15-5, The synthetic route of 16629-15-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

556-90-1, 2-aminothiazol-4(5H)-one is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,556-90-1

2a (1 g, 8.62 mmol) was added to 15 mL of 20% dilute hydrochloric acid and refluxed for 10h. It was concentrated and cooled giving a white solid precipitate. It was filtered, washed, and recystallized with 70% ethanol. Dried to obtain 0.78 g of white needle-like crystals, yield 77.2%.

The synthetic route of 556-90-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; China Pharmaceutical University; Lai, Yisheng; Wang, Hui; Sun, Qirui; Zhang, Yingyi; Li, Yuezhen; Zhang, Yihua; (22 pag.)CN105884712; (2016); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78364-55-3,6-Fluoro-2-hydrazinylbenzo[d]thiazole,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2-hydrazinobenzothiazole 1a (0.825 g, 5 mmol)and alpha-cyanoacetophenone 2a (0.73 g, 5 mmol) was refluxed in ethanol containing acetic acid (3ml) for 5-6 h. Excess solvent was removed by distillation. The crude product so obtained was recrystallized from ethanol to give 5a (1.09 g, 75percent), Mp 201 ¡ã C (lit.[20], 202 ¡ã C). Other compounds (5b-d) of this type were prepared similarly.

78364-55-3, The synthetic route of 78364-55-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Aggarwal, Ranjana; Kumar, Virender; Bansal, Anshul; Sanz, Dionisia; Claramunt, Rosa M.; Journal of Fluorine Chemistry; vol. 140; (2012); p. 31 – 37;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica