55661-33-1, Thiazol-2-ylmethanamine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
55661-33-1, To a round bottom flask with a magnetic stirrer bar 2-(aminomethyl)thiazole (0.46 g, 4 mmol) and 4-methoxybenzaldehyde (1 .22 g, 9 mmol) were added together with 10 ml methanol, NaCNBH3 (0.57 g, 9 mmol) and a few granules of 4A molecular sieve. The solution was stirred overnight at room temperature and the progress of the reaction was monitored by thin layer chromatography (TLC). After filtration the mixture was concentrated in vacuo and the resulting liquid was diluted with 50 ml dichloromethane and extracted with 3×50 ml 0.05 M HCI. The combined aqueous layer was made basic with NaOH until the pH was 10-1 1 and the solution was extracted with 2×150 ml dichloromethane. The organic layers were combined and dried over anhydrous MgS04, filtered and evaporated to give /V,/V-bis(4- methoxybenzyl)-1 -(thiazol-2-yl)methanamine as a dark brown oil. Yield: 1 g (70 %), ,1H NMR (300 MHz, CDCI3): delta 7.73 (1 H, d), 7.29 (5H, m), 6.9 (4H, m), 4.62 (2H, s), 4.13 (2H, s), 3.81 (8H, s),13C NMR (75 MHz, CDCI3): delta 172, 159.2, 158.9, 142.6, 133.4, 131 .8, 129.5, 128.7, 1 18.9, 1 14, 65, 55.4, 52.7, 50.1 .
55661-33-1 Thiazol-2-ylmethanamine 2756507, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; UNIVERSITETET I OSLO; TASKEN, Kjetil; LYGREN, Birgitte; ?STENSEN, Ellen; KLAVENESS, Jo; WO2013/171332; (2013); A2;,
Thiazole | C3H3NS – PubChem
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