With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.7305-71-7,2-Amino-5-methylthiazole,as a common compound, the synthetic route is as follows.
(1) After t-butyl nitrite (1.99 g) was added dropwise to a suspension of 2-amino-5-methyltiazole (2.00 g) in acetonitrile (20 ml) while ice-cooling, copper(II) bromide (4.30 g) was gradually added thereto. This suspension was stirred for 3 hours at 0¡ãC. The reaction solution was charged with 1N hydrochloric acid (100 ml) and then extracted twice with ethyl acetate (200 ml). After the organic layer was dried over anhydrous magnesium sulfate, the solvent was evaporated. The residue was purified by silica gel column chromatography (neutral; hexane:ethyl acetate=80:20) to yield 2-bromo-5-methylthiazole (1.31 g) as a yellow oil. 1H NMR (300 MHz, CDCl3) delta ppm: 2.44 (3H, d, J = 1.2 Hz), 7.25 (1H, d, J = 1.1 Hz)
7305-71-7, Big data shows that 7305-71-7 is playing an increasingly important role.
Reference£º
Patent; TAISHO PHARMACEUTICAL CO., LTD; EP1721905; (2006); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica