With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22514-58-5,2-Bromobenzo[d]thiazole-6-carboxylic acid,as a common compound, the synthetic route is as follows.
STEP A: 2-Bromo-6-benzothiazolecarboxylic acid (496.0 mg, 192 mmol) was suspended in dichloromethane (15 mL), cooled in ice bath, then treated with 2M oxalyl chloride in dichloromethane (2 mL, 4 mmol) and 1 drop of dimethylformamide. The resulting homogenous mixture was stirred for 3 h, then concentrated to a solid. The solid was dissolved in dichloromethane (20 mL), the resulting solution was cooled in an ice bath, then treated with diisopropylethylamine (0.45 mL, 2.58 mmol) and 4-aminoveratole (323.9 mg, 2.11 mmol). The resulting mixture was stirred overnight at room temperature, then diluted with dichloromethane, washed with water, washed with brine, dried over sodium sulfate, filtered and concentrated to yield 2-bromo-N-(3,4-dimethoxyphenyl)benzo[d]thiazole-6-carboxamide as a brown solid. 1HNMR (DMSO-d6) delta 10.3 (s, 1H), 8.69 (s, 1H), 8.10 (s, 2H), 7.47 (d, J=2.23 Hz, 1H), 7.37-7.33 (m, 1H), 6.94 (d, J=8.73 Hz, 1H), 3.76 (s, 3H), 3.75 (s, 3H). MS MH+=393., 22514-58-5
22514-58-5 2-Bromobenzo[d]thiazole-6-carboxylic acid 45789628, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; Jordan, Alfonzo D.; DesJarlais, Renee L.; Hlasta, Dennis J.; Parker, Michael H.; Schubert, Carsten; White, Kimberly; US2011/152287; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica