With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.886361-30-4,Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of P-29 (1g, 3.96mmol) in pyridine (10 mL) was added methanesulfonyl chloride (0.62mL, 7.92mmol) and the resulting mixture was stuffed at 60C over night. Reaction mixture was then brought to room temperature and pyridine was evaporated under reduced pressure. The residue was dissolved in ethyl acetate and washed with saturated aq. sodium bicarbonate, water and brine. Organic layer was dried with anhydrous sodium sulfate, filtered and concentrated. The residue was purified by flash chromatography (hexanes/ethyl acetate) to afford 1g (77%) of product 12. To a stuffed suspension of intermediate 2 (1g, 3mmol) was added 2M LiOH in dioxane (7.5mL, 3mmol) and the solution was stirred for 2h at 40C. The reaction mixture was then gradually acidified with 1N HCl. Diluted with water and extracted with ethyl acetate. Organic layer was washed with brine and dried with anhydrous sodium sulfate. Filtration and evaporation of organic layer afforded 0.9g (94%) of the product S-29., 886361-30-4
886361-30-4 Methyl 2-amino-5-(4-fluorophenyl)thiazole-4-carboxylate 2782963, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; FLYNN, Gary, A.; WO2013/22766; (2013); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica