With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.131748-91-9,2-Bromo-5-(bromomethyl)thiazole,as a common compound, the synthetic route is as follows.
REFERENCE EXAMPLE 9 To a mixture of 1.85g of potassium phthalimide and 20ml of dry DMF were added 2.57g of 2-bromo-5-(bromomethyl)thiazole by portions at room temperature, taking for 20 minutes, followed by stirring for an hour. An insoluble substance was removed by filtration and the filtrate was concentrated. To the residue were added 30ml of ethanol to which 0.60g of hydrazine hydrate were dropwise added within 2 minutes in an oil bath of 20 C. The reaction mixture was refluxed for an hour and concentrated. After adding 20ml of water and 10ml of conc. hydrobromic acid, the mixture was further refluxed for 30 minutes. After cooling, the mixture was neutralized with 20% aqueous sodium hydroxide solution and concentrated. To the residue were 50ml of acetonitrile, and an insoluble substance was removed by filtration. The filtrate was concentrated and the residue was purified by a column chromatography [developing solvent: dichloromethane-methanol (5:1)] to afford 0.76g of 5-(aminomethyl)-2-bromothiazole as a brown oil. 1 H-NMR(CDCl3) 1.59(2H,s), 4.06(2H,d,J=1.2Hz), 7.40(1H,t,J=1.2Hz)., 131748-91-9
As the paragraph descriping shows that 131748-91-9 is playing an increasingly important role.
Reference£º
Patent; Takeda Chemical Industries, Ltd.; US5034404; (1991); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica