Day: September 23, 2020

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78485-37-7,Ethyl 2-chloro-6-benzothiazolecarboxylate,as a common compound, the synthetic route is as follows.

78485-37-7, Ethyl 2-chloro-benzo[d]thiazole-6-carboxylate (362 mg, 1.5 mol)After acidification with hydrochloric acid and (2R,6S)-2,6-dimethylpiperidin-4-one (127 mg, 1.0 mmol)Dissolved in isopropanol (30 mL), reacted at 100 C for 12 hours, concentrated,Purified by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1).The title compound (80 mg, yield: 24.1%) was obtained.

As the paragraph descriping shows that 78485-37-7 is playing an increasingly important role.

Reference£º
Patent; Hainan Xuanzhu Pharmaceutical Technology Co., Ltd.; Shi Chengkong; Chen Bo; (23 pag.)CN109320509; (2019); A;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.247037-82-7,Thiazole-2-carboximidamide hydrochloride,as a common compound, the synthetic route is as follows.

To a suspension of thiazole-2-carboxamidine hydrochloride(5.4 g, 33 mmol), 2-chloro-4-fluorobenzaldehyde (4.74 g,30 mmol), NaOAc (2.71 g, 33 mmol) in anhydrous EtOH (60 mL)was added tert-butyl 3-oxobutanoate (4.74 g, 33 mmol). The reactionmixture was refluxed at 80 C under N2 atmosphere overnight.Then the mixture was concentrated in vacuo and diluted withEtOAc, washed with water, brine, and the combined organic phasewas dried over Na2SO4, concentrated in vacuo to give a crude product,which was purified by silica gel chromatography (petrolether/ethyl acetate (V/V) = 5/1) to give a yellow solid (6.1 g, 50%). 1H NMR (600 MHz, CDCl3): d 7.82 (d, 1H, J = 4.2 Hz), 7.49 (br s,1H), 7.33 (dd, 1H, J = 13.2 Hz, 9.6 Hz), 7.14 (dd, 1H, J = 12.6 Hz,3.6 Hz), 6.95 (td, 1H, J = 12.6 Hz, 3.6 Hz), 6.12 (s, 1H), 2.54 (s, 3H),1.30 (s, 9H); MS-ESI: (ESI, pos.ion) m/z: 408.1 [M+1]+; HRMS (ESI)calcd for C19H19ClFN3O2S [M+H]+ 408.0871; found 408.0949; HPLCanalysis: retention time = 23.19 min; peak area, 97.67%., 247037-82-7

Big data shows that 247037-82-7 is playing an increasingly important role.

Reference£º
Article; Ren, Qingyun; Liu, Xinchang; Luo, Zhonghua; Li, Jing; Wang, Chaolei; Goldmann, Siegfried; Zhang, Jiancun; Zhang, Yingjun; Bioorganic and Medicinal Chemistry; vol. 25; 3; (2017); p. 1042 – 1056;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

2103-99-3, 4-(4-Chlorophenyl)thiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A solution of 2-amino-4-phenylthiazole 6a (0.530 g, 3 mmol) and Et3N (560 muL, 4 mmol) in dichloromethane (15 mL) was cooled to 0-5 C in an ice-bath and stirred for 30 min. 2-Chloroacetyl chloride (578 muL, 6.6 mmol) in dry dichloromethane (1.5 mL) was then added slowly, and the reaction mixture was allowed to warm to room temperature and stirred until the amine was completely consumed (ca. 1 h, as monitored by TLC). The reaction mixture was diluted with dichloromethane and washed successively with water and saturated brine. The organic layer was dried over anhydrous Na2SO4, the solvent was removed under reduced pressure and the residue was recrystallised from ethanol to give compound 7a (0.413 g, 54percent) as light-grey crystals, mp 170-171 oC (Lit.18,20,26 171-173 oC). The remaining analogues were obtained similarly [7b (100percent) as a brown solid, mp 194-195 oC (Lit.27 mp not cited); 7c (64percent) as a brown solid, mp 241-243 oC (Lit.27 mp not cited); 7d (64percent) as a brown solid, mp 135-137 oC (Lit.28 135 oC); 7e (0.262 g, 88percent) as a yellow solid, mp 174-176 C (Lit.29 175 oC); 7f (70percent) as a light-brown solid, mp 213-216 oC (Lit.30 216 oC)., 2103-99-3

The synthetic route of 2103-99-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Olawode, Emmanuel O.; Tandlich, Roman; Prinsloo, Earl; Isaacs, Michelle; Hoppe, Heinrich; Seldon, Ronnett; Warner, Digby F.; Steenkamp, Vanessa; Kaye, Perry T.; Arkivoc; vol. 2018; 7; (2018); p. 110 – 118;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20485-41-0,4-Methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

The title compound N-[5(S)-3-[4-(1-cyanocyclopropan-1-yl)phenyl]-2-oxooxazolidin-5-ylmethyl]-(4-methyl-1,3-thiazole)-5-carboxamide (215 mg) was prepared from 5(S)-aminomethyl-3-[4-(1-cyanocyclopropan-1-yl)phenyl]oxazolidin-2-one (150 mg) and 4-methyl-1,3-thiadiazole-5-carboxylic acid (100 mg) in the same manner as described for EXAMPLE 62. [0516] MS (EI+) m/z: 382 (M+). [0517] HRMS (EI+) for C19H18N4O3S (M+): calcd, 382.1100; found, 382.1121.

20485-41-0, As the paragraph descriping shows that 20485-41-0 is playing an increasingly important role.

Reference£º
Patent; Fukuda, Yasumichi; US2003/225107; (2003); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

39136-60-2, 5-Ethylthiazol-2-amine is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 5-ethylthiazol-2-amine (5) (0.13 g, 1.0 mmol), 2-(4-nitrophenyl)-acetonitrile (6) (0.18 g, 1.1 mmol), 3-nitrobenzaldehyde (8a)(0.17 g, 1.1 mmol), SiO2-ZnBr2 (0.10 g), and diisopropylethylamine (DIPEA) (0.033 g, 0.25 mmol) was taken into a microwave glass vial containing EtOH (4 ml). The glass vial was placed in the cavity of microwave oven (465 W power) and irradiated for 4 min at 70C and then cooled to 27C after completion of the reaction (TLC). EtOH (5 ml) was added to the reaction mixture, and then it was filtered to recover the catalyst. The organic layer was concentrated under vacuum to obtain the crude product which was purified by column chromatography using CH2Cl2-MeOH in the ratio of 99.5:0.5 to 97.0:3.0, adjusted to the elution rate of the individual product, as mobile phase. Yield 0.41 g (96%), pale-yellow solid. IR spectrum, nu, cm-1: 3392 (N-H), 2984 (C-H), 1615 (C=N), 1552 (C=C), 1505 (NO2), 1340(NO2). 1H NMR spectrum, delta, ppm (J, Hz): 1.16 (3H, t,J = 7.6, CH3); 2.75 (2H, q, J = 7.6, CH2); 5.26 (2H, s,NH2); 6.18 (1H, s, 5-CH); 7.21 (1H, s, H-3); 7.69-8.01(5H, m, H Ar); 8.18 (1H, s, H Ar); 8.26 (2H, d, J = 6.8,H Ar). 13C NMR spectrum, delta, ppm: 13.5; 35.7; 53.2; 110.9;114.8; 121.9; 122.6; 125.3; 128.7; 130.3; 132.1; 136.5;140.6; 145.2; 147.0; 148.4; 149.8; 169.2. Mass spectrum,m/z (Irel, %): 424 [M+H]+ (100), 349 (21). Found, m/z:424.1056 [M+H]+. C20H18N5O4S. Calculated, m/z: 424.1074.

39136-60-2, 39136-60-2 5-Ethylthiazol-2-amine 12737257, athiazole compound, is more and more widely used in various fields.

Reference£º
Article; Devineni, Subba Rao; Madduri, Thirupal Reddy; Chamarthi, Naga Raju; Liu, Cong-Qiang; Pavuluri, Chandra Mouli; Chemistry of Heterocyclic Compounds; vol. 55; 3; (2019); p. 266 – 274; Khim. Geterotsikl. Soedin.; vol. 55; 3; (2019); p. 266 – 274,9;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example – 1: Preparation of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyI thiozole -5-carboxylateA mixture of 10. Og of Ethyl -2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole -5- carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 40 g of Dimethyl sulfoxide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 70 -80¡ãC for 2-3 hours. Reaction mass was cooled to room temperature and to this 19 g of potassium carbonate and 19 g of isobutyl bromide was added successively. The reaction mass was stirred for 5 hours at 70-80¡ãC. Reaction mass was diluted with 200 ml of purified water. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyl thiozole -5-carboxyltae (yield 84.0percent), 161798-01-2

As the paragraph descriping shows that 161798-01-2 is playing an increasingly important role.

Reference£º
Patent; MATRIX LABORATORIES LTD; VELLENKI, Siva Rama Prasad; ARABINDA, Sahu; RAAVI, Satyanarayana; NUCHU, Ravi; DANDALA, Ramesh; WO2012/66561; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.405939-39-1,tert-Butyl (5-bromothiazol-2-yl)carbamate,as a common compound, the synthetic route is as follows.

Example 18, Step F[00180] To (i-Pr)2NH (59.7 g, 0.591 mol) in THF (250 mL) at 0C was added n-BuLi (236 mL, 2.5 M, 0.591 mol) was added slowly. The reaction mixture was stirred for 20 mins after which a THF solution of compound 15_2 (50 g, 0.179 mol) was slowly added to the reaction mixture with continued stirring. The mixture was stirred for 30 mins at 0C and then DMF (43.1 g, 0.591 mol) added. The mixture was stirred for 12 hrs at r.t. and diluted with EtOAc and water. The organic layer was separated, washed with brine, dried over Na2S04 and concentrated in vacuo. The residue was purified by silica chromatography to give compound 18_1 (35 g, 64%) as a white solid. [00181] This compound was characterized by proton NMR (1HNMR) in accordance with the procedures described herein. Proton NMR yielded the following results: 1H NMR (DMSO-d6, 400MHz): delta 9.73(s, 1 H); 1.47(s, 9H)., 405939-39-1

The synthetic route of 405939-39-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; ADDEX PHARMA S.A.; LIVERTON, Nigel, J.; BOLEA, Christelle; CELANIRE, Sylvain; YUNFU, Luo; WO2012/8999; (2012); A2;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20485-41-0,4-Methylthiazole-5-carboxylic acid,as a common compound, the synthetic route is as follows.

Example 144N-((ls,4s)-4-(2-(4′-(((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)-2′- (morpholinomethyl)biphenyl-3-yloxy)-5-fluoronicotinamido)cyclohexyl)-4- methylthiazole-2-carboxamide EDCI (0.021 g, 0.11 mmol) was added to a solution of 4-methylthiazole-2-carboxylic acid (0.016 g, 0.11 mmol) and lH-benzo[d][l,2,3]triazol-l-ol hydrate (0.017 g, 0.11 mmol) in THF (2 mL) and stirred for 10 min. A solution of N-((ls,4s)-4-aminocyclohexyl)-2-(4′- (((3S,5R)-3,5-dimethylpiperazin-l-yl)methyl)-2′-(morpholinomethyl)biphenyl-3-yloxy)-5- fluoronicotinamide (0.075 g, 0.10 mmol) and triethylamine (0.042 mL, 0.30 mmol) in DMF (2 mL) was then added and the reaction stirred for 20 h. The reaction was diluted with 10percent 2M HCl/MeCN (1 mL) and purified by reverse phase HPLC with aqTFA/MeOH as eluent to afford the title compound as a white solid. Yield: 70 mg1H NMR (400 MHz, CD3OD) delta 8.14 (d, J= 2.9 Hz, IH), 8.04 (m, IH), 7.74 (m, IH), 7.58 (t, J= 7.9 Hz, IH), 7.51 (m, IH), 7.38 (m, 2H), 7.32 (m, IH), 7.20 (m, IH), 7.16 (m, IH), 4.43 (s, 2H), 4.12 (m, IH), 3.98 (m, IH), 3.90 – 3.66 (m, 4H), 3.79 (s, 2H), 3.43 (m, 2H), 3.29 – 2.74 (m, 4H), 3.13 (m, 2H), 2.44 (s, 3H), 2.27 (t, J= 12.3 Hz, 2H), 1.93 – 1.74 (m, 8H), 1.29 (d, J= 6.6 Hz, 6H). MS: APCI (+ve):756 (M+l), 20485-41-0

20485-41-0 4-Methylthiazole-5-carboxylic acid 209805, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

170961-15-6, tert-Butyl thiazol-2-ylcarbamate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: n-BuLi (2.5M in THF, 1.4equiv) was added drop wise to a mixture of compound 1a or 1b (1equiv) and aldehyde (1.2equiv) in THF (?20mL) at -78C for 2h. The reaction was quenched by adding a saturated aqueous solution of NH4Cl, extracted with EtOAc, washed with water and then brine. The organic phase was dried over anhydrous Na2SO4, evaporated, and the residue was purified by silica gel column chromatography

170961-15-6, As the paragraph descriping shows that 170961-15-6 is playing an increasingly important role.

Reference£º
Article; Khalil, Ahmed; Edwards, Jessica A.; Rappleye, Chad A.; Tjarks, Werner; Bioorganic and Medicinal Chemistry; vol. 23; 3; (2015); p. 532 – 547;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica

161798-01-2, Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate is a thiazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example – 1: Preparation of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyI thiozole -5-carboxylateA mixture of 10. Og of Ethyl -2-(3-formyl-4-hydroxy phenyl)-4-methyl thiozole -5- carboxylate and 2.85 g of hydroxylamine hydrochloride were stirred for 30 minutes in 40 g of Dimethyl sulfoxide. To this reaction mixture 3.3 grams of acetyl chloride was added and stirred at 70 -80¡ãC for 2-3 hours. Reaction mass was cooled to room temperature and to this 19 g of potassium carbonate and 19 g of isobutyl bromide was added successively. The reaction mass was stirred for 5 hours at 70-80¡ãC. Reaction mass was diluted with 200 ml of purified water. The reaction mass was filtered and washed with purified water to give 10.0 g of Ethyl-2-(3-cyano-4-isobutoxy phenyl)-4-methyl thiozole -5-carboxyltae (yield 84.0percent)

161798-01-2, 161798-01-2 Ethyl 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate 135404723, athiazole compound, is more and more widely used in various fields.

Reference£º
Patent; MATRIX LABORATORIES LTD; VELLENKI, Siva Rama Prasad; ARABINDA, Sahu; RAAVI, Satyanarayana; NUCHU, Ravi; DANDALA, Ramesh; WO2012/66561; (2012); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica