With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.349-49-5,4-(Trifluoromethyl)thiazol-2-amine,as a common compound, the synthetic route is as follows.
To a solution of 5-(1-methylsulfanyl-ethyl)2-trifluoromethylpyridine (0.5 g, 2.25 mmol) and 2-amino-4-trifluoromethyl thiazole (0.42 g, 2.48 mmol) in dichloromethane (8 ml) cooled to -25¡ã C. was slowly added N-chlorosuccinamide (0.33 g, 2.48 mmol) while maintaining the internal temperature of the reaction between -22¡ã C. and -28¡ã C. The reaction was slowly warmed to room temperature and stirred an additional hour. The reaction mixture was washed with water and the dichloromethane layer was dried (MgSO4), filtered and concentrated to dryness. The crude product was purified by chromatography on silica gel (eluent: 50percent EtOAc/hexanes, 100percent EtOAc) to give 3-[1-ethyl(N-(2-(4-trifluromethyl)thiazole)-sulfinyl)(methyl)]-6-trifluoromethylpyridine (G) as a yellow solid (0.81 g, 93percent ); M+H=288.1., 349-49-5
The synthetic route of 349-49-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Dow AgroSciences LLC; US2009/29863; (2009); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica