With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.56012-38-5,(2-Methylthiazol-5-yl)methanol,as a common compound, the synthetic route is as follows.
Step 6: Intermediate 5-h: To a solution of intermediate 5-g (1.0 g, 105.0 mmol) and intermediate 5-d (352 mg, 2.73 mmol) in THF (20 ml) were sequentially added triphenylphosphine (1.07 g, 4.1 mmol) and DIAD (796 p1, 4.1 mmol) at room temperature and the reaction was then stirred at room temperature for 1 hour. Volatiles were removed under reduced pressure. Purification by silica gel chromatography provided intermediate 5-h as yellow oil., 56012-38-5
56012-38-5 (2-Methylthiazol-5-yl)methanol 12808792, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; WO2014/29007; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica