62266-82-4,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62266-82-4,6-Bromobenzo[d]thiazol-2(3H)-one,as a common compound, the synthetic route is as follows.
tert-butyl 4-[(6-bromo-2-oxo-l ,3-benzothiazol-3(2H)-yl)methyl]piperidine-l- carboxylate (11-1) , ,To a round bottom flask was added 6-bromo-l,3-benzothiazol-2(3H)-one (0.300 g, 1.304 mmol), tert-butyl 4-(hydroxymethyl)piperidine-l -carboxylate (0.365 g, 1.695 mmol), triphenylphosphine (0.455 g, 1.695 mmol), diisopropyl (E)-diazene-l,2-dicarboxylate (DIAD) (0.330 mL, 1.695 mmol), and NMP (5 mL). The reaction mixture was then permitted to stir at room temperature for two hours. The crude reaction mixture was then diluted with methanol, filtered and concentrated. Purification of crude reaction mixture by reverse phasechromatography (Waters Sunfire MSC18, 30% acetonitrile / 0.1% trifluoroacetic acid / water? 100% acetonitrile / 0.1 % trifluoroacetic acid / water) fer/-butyl 4-[(6-bromo-2-oxo-l,3- benzothiazol-3(2H)-yl)methyl]piperidine-l -carboxylate (11-1) as a tan solid. HRMS (M+H)+: observed = 427.0691 , calculated – 427.0686.
62266-82-4 6-Bromobenzo[d]thiazol-2(3H)-one 188444, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; MERCK SHARP & DOHME CORP.; LAYTON, Mark, E.; KELLY, Michael, J.; WO2011/137046; (2011); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica