With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34259-99-9,4-Bromothiazole,as a common compound, the synthetic route is as follows.
a) 6- (Thiazol-4-yl)- 8-((2- (trimethylsilyl)ethoxy)methoxy)-3- ((2- (trimethylsilyl)ethoxy)methyl)guinazolin-4(3H)-oneA suspension of 4-bromo-thiazole (0.02 g, 0.1 mmol), (6-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-8- ((2- (trimethylsilyl)ethoxy)methoxy)-3-((2-(trimethylsilyl)ethoxy)methyl)quinazolin-4(3H)-one (0.05 g, 0.08 mmol, example 28), bis (diphenylphosphino)feffocene-palladium(II)dichloride (0.01 g, 0.01 mmol), potassium carbonate (0.03 g, 0.25 mmol) and water (0.2 ml) in dimethylformamide (1 ml) was stirred in a sealed tube at 100 ¡ãC for 2 hours and then at 80 ¡ãC overnight. Filtration and chromatography (C18 reverse phase HPLC, methanol / water (0.1percent formic acid) = 40:60 to 100:0) yielded thetitle compound as white solid (0.01 g, 18 percent). MS: mle = 506.7 [M+Hf?., 34259-99-9
34259-99-9 4-Bromothiazole 2763218, athiazole compound, is more and more widely used in various fields.
Reference£º
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BISSANTZ, Caterina; BONNAFOUS, Rene; BUETTELMANN, Bernd; JAKOB-ROETNE, Roland; LERNER, Christian; RUDOLPH, Markus; WO2014/102233; (2014); A1;,
Thiazole | C3H3NS – PubChem
Thiazole | chemical compound | Britannica